Metastatic sigmoid colon adenocarcinoma and tumour‐related sarcoid reaction

Gregorio, Michael De; Brett, Andrew

doi:10.1111/imj.13812

Cited by 2 publications

(2 citation statements)

References 22 publications

(25 reference statements)

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“…Only one case of drug-induced sarcoid reaction could be diagnosed as sarcoid reaction by radiological findings after the drug was withheld [ 24 ]. Most sarcoid reactions are discovered at the time of primary tumor resection [ 5 , 6 , 8 , 9 , 13 , 16 , 18 , 20 – 22 , 26 , 27 , 29 , 30 ]; however, some (both drug-induced and non-drug-induced sarcoid reactions) are discovered 1 month to 5 years after surgery [ 10 , 14 , 15 , 17 , 19 , 23 , 25 , 28 , 31 ]. Granuloma formation is often found in lymph nodes, whereas spleen sarcoid reactions are more frequently found with non-drug-induced sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Splenic sarcoid reaction mimicking metastases in patients after uterine cancer surgery: a report of two cases

Kitamura,

Ogura,

Miyamoto

et al. 2023

surg case rep

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Background Tumor-associated sarcoid reactions have been observed with various tumors; however, they have not been reported with uterine cancer. We present two cases of splenic sarcoid reactions that mimicked metastases a few years after uterine cancer surgery. Case presentation Case 1 involved a 67-year-old female patient diagnosed with endometrial cancer (pT1aN0M0, pStage Ia, grade 1). The patient underwent open total abdominal hysterectomy and bilateral salpingo-oophorectomy with pelvic lymphadenectomy. Three years after the initial surgery, computed tomography (CT) and positron emission tomography CT showed multiple splenic masses with increasing numbers and sizes. Splenic metastases were diagnosed, and laparoscopic splenectomy was performed. The histopathological analysis revealed sarcoid reactions in the spleen. Case 2 involved a 47-year-old female patient diagnosed with endometrial cancer (pT1aN0M0, pStage Ia, grade 1). The patient underwent laparoscopic total abdominal hysterectomy and bilateral salpingo-oophorectomy with pelvic lymphadenectomy. Two years after the initial surgery, multiple splenic masses were observed. We performed laparoscopic splenectomy for the splenic metastases. Granuloma formations were identified in the splenic specimen and perisplenic lymph nodes that were removed simultaneously, resulting in a final diagnosis of sarcoid reaction. A review of the lymph nodes at the time of the previous uterine surgery revealed granuloma formation. Other than the presence of splenic masses, no findings suggestive of recurrence were observed in these cases. Uterine cancer and sarcoid reactions progressed without recurrence after splenectomy. Conclusions To the best of our knowledge, this is the first report of the late development of splenic sarcoid reactions after uterine cancer surgery. Sarcoid reactions and metastases are difficult to diagnose based on preoperative imaging results. However, reviewing the specimen at the time of the initial resection, the number of lesions, and the clinical findings (other than imaging findings) may aid in the determination of the correct diagnosis.

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Section: Discussionmentioning

confidence: 99%

Splenic sarcoid reaction mimicking metastases in patients after uterine cancer surgery: a report of two cases

Kitamura,

Ogura,

Miyamoto

et al. 2023

surg case rep

View full text Add to dashboard Cite

show abstract

“…Although various types of malignancies, including lymphoma ( 11 , 12 ), breast cancer ( 13 , 14 ), stomach cancer ( 15 , 16 ), colon cancer ( 17 , 18 ), and lung cancer ( 19 , 20 ), have been reported to be associated with SLR development, its clinical significance in cancer patients remains unclear. In previous studies ( 14 , 21 ), SLR has been associated with better cancer outcomes.…”

Section: Introductionmentioning

confidence: 99%

Sarcoid-like reaction in patients with malignant tumors: Long-term clinical course and outcomes

2022

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BackgroundThe development of non-caseating epithelioid cell granulomas in cancer patients who do not fulfill the systemic sarcoidosis criteria is termed sarcoid-like reaction (SLR). Little is known about this condition's natural course and impact on the prognosis of malignancy. We aimed to investigate the natural course and prognostic value of cancer-associated SLR.MethodsClinical data were retrospectively analyzed in 32 patients with biopsy-proven cancer-associated SLR. Among patients with non-small cell lung cancer (NSCLC), SLR cases (n = 8) were matched with non-SLR cases (n = 78) for survival analysis.ResultsAmong the included patients, the mean age was 59.7 years, and 68.8% were female. The median follow-up period was 35.6 months [interquartile range (IQR): 14.0–61.4 months]. Of all the included malignancies (n = 32), breast cancer (25.0%) and NSCLC (25.0%) were the most common, with stage I being the most frequent tumor stage (59.4%). During follow-up, SLR progression to overt sarcoidosis was not observed. In the 28 patients with available follow-up computed tomography images (median interval: 24.9 months; IQR: 14.4–41.7), 4 patients received corticosteroids (n = 4), resulting to a decrease of SLR lesions. Meanwhile, among those who did not receive treatment (n = 24), the extent of SLR decreased or did not change in 85.7% of them, whereas 3.6% had increased SLR extent. Furthermore, among patients with NSCLC, SLR was not associated with overall survival [hazard ratio (HR) = 1.28, 95% confidence interval (CI): 0.02–67.71, P = 0.882] and recurrence of malignancy (HR = 1.27, 95% CI 0.21–7.51, P = 0.793) in the Cox proportional hazard regression model.ConclusionsDuring the follow-up of cancer-related SLR, we found no further evidence for systemic sarcoidosis, and most of the lesions decreased or did not change. Development of SLR was also not associated with overall survival or disease-free survival in patients with NSCLC.

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Metastatic sigmoid colon adenocarcinoma and tumour‐related sarcoid reaction

Cited by 2 publications

References 22 publications

Splenic sarcoid reaction mimicking metastases in patients after uterine cancer surgery: a report of two cases

Splenic sarcoid reaction mimicking metastases in patients after uterine cancer surgery: a report of two cases

Sarcoid-like reaction in patients with malignant tumors: Long-term clinical course and outcomes

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