Metastatic Serous Borderline Ovarian Tumor in an Internal Mammary Lymph Node: A Case Report and Review of the Literature

Chamberlin, Mary D.; Eltabbakh, Gamal H.; Mount, Sharon L.; Leavitt, Bruce J.

doi:10.1006/gyno.2001.6234

Cited by 21 publications

(14 citation statements)

References 8 publications

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“…For example, Tan et al (10) described two patients with recurrences in cervical nodes 4 and 7 years following treatment of stage 3 ovarian SBTs. Silva et al (7) described 2 patients with cervical node recurrences 7 and 20 years following treatment of ovarian SBTs, and Chamberlin et al (11) reported recurrent tumor involving an internal mammary lymph node that was incidentally discovered at cardiac surgery 7 years after excision of the patient's SBT. In contrast, the patient in this report (case 1) developed recurrent tumor in an axillary lymph node just 27 months after the diagnosis of the primary tumor.…”

Section: Discussionmentioning

confidence: 97%

“…The recurrences are often delayed, sometimes occurring years after diagnosis, and usually take the form of SBT or low-grade serous carcinoma (6)(7)(8)(9). The pelvis and abdomen are the usual sites of recurrences, but spread to other sites occasionally occurs (7,(9)(10)(11). In this study, we report the findings in 2 patients diagnosed with ovarian SBTs in whom recurrences developed within a short interval after their initial diagnoses, one in an axillary lymph node and the other in an incisional hernia sac.…”

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confidence: 98%

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Early Recurrence of Ovarian Serous Borderline Tumor as High-grade Carcinoma: A Report of Two Cases

Parker

Clement

Chercover

et al. 2004

International Journal of Gynecological Pathology

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Ovarian serous borderline tumors (SBTs) are characteristically associated with an indolent course. Recurrences are often delayed and usually show morphologic features of SBT or low-grade serous carcinoma. Transformation to high-grade carcinoma has rarely been documented. We report 2 cases of ovarian SBTs that recurred early as high-grade carcinomas. The first was a 50-year-old woman treated surgically and with chemotherapy for a FIGO stage 1C SBT with microinvasion, who experienced a recurrence in an axillary lymph node at 27 months. The recurrent tumor consisted of well-differentiated papillary serous tumor that resembled the primary tumor and poorly differentiated serous carcinoma. The patient died of progressive disease 43 months after her initial presentation. The second case was a 61-year-old woman treated surgically and with chemotherapy for a stage 3C micropapillary SBT with noninvasive implants. Eighteen months later, an incisional hernia was found that contained high-grade sarcomatoid-type carcinoma with microscopic foci of better differentiated tumor that resembled the primary SBT. This patient is alive with disease 24 months after her initial presentation. Whereas the malignant potential of SBTs remains controversial, the cases described herein demonstrate that SBTs can behave unpredictably and may rarely transform into high-grade carcinoma.

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 98%

Early Recurrence of Ovarian Serous Borderline Tumor as High-grade Carcinoma: A Report of Two Cases

Parker

Clement

Chercover

et al. 2004

International Journal of Gynecological Pathology

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“…The pelvic, peritoneal, and paraaortic nodal groups are the ones most frequently found to be involved because these are the groups that are routinely excised during surgical staging (1,3,4). However, supradiaphragmatic lymph nodes such as the supraclavicular, mammary, axillary, and cervical groups may also be involved (3,(5)(6)(7)(8)(9), and associated symptoms may potentially be the first clinical manifestation of an ovarian SBT (6). Furthermore, lymph nodes may be the site of recurrence and/or progression to carcinoma of an ovarian SBT (5,(9)(10)(11)(12)(13).…”

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confidence: 98%

A Comparative Analysis of Lymphatic Vessel Density in Ovarian Serous Tumors of Low Malignant Potential (Borderline Tumors) With and Without Lymph Node Involvement

Fadare

Orejudos

Jain

et al. 2008

International Journal of Gynecological Pathology

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Lymph node involvement is seen in approximately one quarter of women with surgically staged ovarian serous tumors of low malignant potential (serous borderline tumors), and this finding apparently does not adversely impact their overall survival. To help illuminate some of the pathomechanisms underlying this novel phenomenon, in which a largely noninvasive epithelial neoplasm is able to exit its primary site and be transported to lymph nodes with such a substantial frequency, we investigated whether significant differences in lymphatic vessel density exist between ovarian serous borderline tumors that show lymph node involvement and those that do not. The lymphatic vessel density of 13 conventional ovarian serous borderline tumors (i.e. tumors without stromal microinvasion, micropapillary/cribriform areas, or invasive implants) with at least 1 positive lymph node (study group) was compared with the lymphatic vessel density of an age- and disease extent-matched control group of 13 similarly selected lymph node-negative ovarian serous borderline tumors. Lymphatic vessel density was determined by counting the total number of vascular spaces immunohistochemically stained by the lymphatic endothelium marker D2-40 in 5 consecutive microscopic fields (x20 objective, field area of 1 microscopic field, 0.95 mm) in the most vessel-dense areas and calculating the average value per microscopic field. The peritumoral lymphatic vessel density was significantly higher than the intratumoral lymphatic vessel density in both groups. However, no statistically significant differences were found between the study and control groups regarding intratumoral lymphatic vessel density (8.0 vs. 7.61; P=0.77), peritumoral lymphatic vessel density (20.33 vs. 21.0; P=0.79), or combined, that is, peritumoral plus intratumoral lymphatic vessel density (27.81 vs. 28.62; P=0.83). Our findings, in conjunction with others in the medical literature, do not support a role for tumor lymphatics in nodal metastasis in this neoplasm. We discuss the possibility that nodal deposits may represent metastatic disease from secondary tumor implants.

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“…Distant metastases and especially involved supradiaphragmatic lymph nodes are likely to be more frequently found than expected, as depicted in several reports [62][63][64][65][66][67]. In a recent prospective study of 30 patients with advancedstage OC, Hynninen et al [68] investigated the presence and distribution of supradiaphragmatic lymph nodes at the presurgical stage, with 67% of lesions identified by 18 F-FDG PET/CT versus 33% by CT.…”

Section: F-pet/ct and F-pet/cectmentioning

confidence: 90%

Management of epithelial ovarian cancer from diagnosis to restaging

Musto

Grassetto²,

Marzola³

et al. 2014

Nuclear Medicine Communications

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Epithelial ovarian carcinoma is a major form of cancer affecting women in the western world. The silent nature of this disease results in late presentation at an advanced stage in many patients. It is therefore important to assess the role of imaging techniques in the management of these patients. This article presents a review of the literature on the role of (18)F-FDG-PET/CT in the different stages of management of epithelial ovarian cancer. Moreover, a comparison with other imaging techniques has been made and the relationship between (18)F-PET/CT and the assay of serum CA-125 levels has been discussed.

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Metastatic Serous Borderline Ovarian Tumor in an Internal Mammary Lymph Node: A Case Report and Review of the Literature

Cited by 21 publications

References 8 publications

Early Recurrence of Ovarian Serous Borderline Tumor as High-grade Carcinoma: A Report of Two Cases

Early Recurrence of Ovarian Serous Borderline Tumor as High-grade Carcinoma: A Report of Two Cases

A Comparative Analysis of Lymphatic Vessel Density in Ovarian Serous Tumors of Low Malignant Potential (Borderline Tumors) With and Without Lymph Node Involvement

Management of epithelial ovarian cancer from diagnosis to restaging

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