Metastatic Sarcomatoid Carcinoma of the Small Intestine: a Case Report of Rare Tumor with Literature Review

Khelfa, Yousef; Alsharedi, Mohamed; Mehmi, Inderjit; Raufi, Ali; Arrington, Amanda K.; Lebowicz, Yehuda; Pacioles, Toni

doi:10.1007/s12029-015-9778-0

Cited by 2 publications

(3 citation statements)

References 10 publications

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“…3), intraabdominal fluid accumulation, localized intestinal wall thickening, and possible intestinal intussusception (Figs. [4][5][6]. Emergency surgery was performed, and exploration revealed the presence of 4 tumors in the small intestine (Figs.…”

Section: Case Presentationmentioning

confidence: 99%

“…Diagnosis relies on pathology and immunohistochemical examination, and surgery is the main treatment method, with a poor prognosis. [5] Our hospital has treated 1 case, with more than 2 years of Informed written consent was obtained from the patient for publication of this report and any accompanying images.…”

Section: Introductionmentioning

confidence: 99%

“…Diagnosis relies on pathology and immunohistochemical examination, and surgery is the main treatment method, with a poor prognosis. [ 5 ] Our hospital has treated 1 case, with more than 2 years of diagnosis and treatment. By reviewing the patient diagnosis and treatment experience and literature review, we hope to provide a reference for the diagnosis and treatment decision-making of sarcomatoid carcinoma of the small intestine.…”

Section: Introductionmentioning

confidence: 99%

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Multiple sarcomatoid carcinomas in the small intestine with perforation: A case report and literature review

Wang,

Zhang,

et al. 2024

Medicine

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Rationale: Sarcomatoid carcinoma of the small intestine is an exceedingly rare and aggressive malignancy, often diagnosed at advanced stages with a poor prognosis. This study documents a detailed case of sarcomatoid carcinoma of the small intestine, highlighting the diagnostic challenges and treatment approaches, underscored by a comprehensive review of related literature. Given the rarity of this condition, our report aims to enrich the existing diagnostic and treatment frameworks for this malignancy, emphasizing the necessity for early detection and intervention strategies. By presenting this case in conjunction with a literature review, we seek to shed light on the elusive nature of sarcomatoid carcinoma in the small intestine and propose avenues for improving patient outcomes. Patient concerns: Case presentation A 61-year-old male patient initially presented with recurrent abdominal pain and gastrointestinal symptoms. Initial abdominal computed tomography (CT) scans and gastrointestinal endoscopy revealed only inflammatory and hyperplastic changes in the duodenum and jejunum, with a diagnosis of intestinal obstruction. Two years later, due to gastrointestinal perforation, the patient was hospitalized again. Diagnoses: CT scans and other examinations revealed small intestinal lesions. Four small intestinal lesions were surgically removed, and pathology and immunohistochemistry confirmed sarcomatoid carcinoma of the small intestine. A short time later, enhanced CT scans revealed metastatic lesions in the hepatic portal and adrenal glands. Interventions: After surgery, the gastrointestinal function gradually recovered, and the patient was discharged from the hospital on a semiliquid diet. No further treatment such as radiotherapy or chemotherapy was administered postoperatively. Outcomes: Five months after the surgery, the patient died due to brain metastasis. Lessons: The study outcomes reveal the aggressive nature of sarcomatoid carcinoma of the small intestine, characterized by rapid progression and poor prognosis despite surgical interventions. The patient condition rapidly deteriorated, leading to metastasis and death within 5 months postsurgery. These findings underscore the critical need for early detection and possibly innovative treatment approaches to improve survival rates. This case also highlights the potential for gastrointestinal sarcomatoid carcinoma to metastasize to distant organs, including the brain, suggesting a propensity for hematogenous spread.

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Section: Case Presentationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Diagnosis relies on pathology and immunohistochemical examination, and surgery is the main treatment method, with a poor prognosis. [ 5 ] Our hospital has treated 1 case, with more than 2 years of diagnosis and treatment. By reviewing the patient diagnosis and treatment experience and literature review, we hope to provide a reference for the diagnosis and treatment decision-making of sarcomatoid carcinoma of the small intestine.…”

Section: Introductionmentioning

confidence: 99%

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Multiple sarcomatoid carcinomas in the small intestine with perforation: A case report and literature review

Wang,

Zhang,

et al. 2024

Medicine

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Jejunal sarcomatoid carcinoma: A case report and review of literature

Feng,

Yu,

Feng

et al. 2024

World J Gastrointest Oncol

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BACKGROUND Sarcomatoid carcinoma (SCA) of the jejunum is a rare and aggressive neoplasm affecting the smooth muscle cells of the jejunum. This study presents a recent case of jejunal SCA, detailing its diagnosis and treatment, thereby providing a reference for clinical practice. CASE SUMMARY A 65-year-old male presented to Yichang Central People's Hospital with a chief complaint of hemorrhoids. A computed tomography (CT) scan incidentally revealed multiple abnormal signals in the liver. Subsequent positron emission tomography/CT at Wuhan Union Hospital indicated malignant tumor progression, with a primary duodenal tumor and multiple metastases in the upper left abdomen. Intraoperatively, a large tumor was identified on the omentum. Histopathological and immunohistochemical analyses of the resected specimen confirmed the diagnosis of jejunal SCA. The patient received a combination therapy of sintilimab, nanoparticle albumin-bound paclitaxel, and anlotinib. Follow-up imaging demonstrated significant reduction of hepatic and peritoneal lesions. The patient has remained stable for over one year postoperatively. CONCLUSION This case suggests that chemotherapy, immunotherapy, plus targeted therapy may represent an optimal treatment for intestinal SCA, meriting further investigation.

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Metastatic Sarcomatoid Carcinoma of the Small Intestine: a Case Report of Rare Tumor with Literature Review

Cited by 2 publications

References 10 publications

Multiple sarcomatoid carcinomas in the small intestine with perforation: A case report and literature review

Multiple sarcomatoid carcinomas in the small intestine with perforation: A case report and literature review

Jejunal sarcomatoid carcinoma: A case report and review of literature

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