Metastatic Renal Cell Carcinoma to the Thyroid 23 Years After Nephrectomy

Valdez, Carrie; Rezaei, M. Katayoon; Hendricks, Frederick; Knoll, Stanley M.

doi:10.1016/j.eucr.2014.04.002

Cited by 7 publications

(6 citation statements)

References 6 publications

(5 reference statements)

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“…Thyroid nodules are quite common, occurring in up to 50% of the population, as indicated by ultrasonography; only about 5% of these nodules are thyroid cancer (1). A metastatic neoplasm of the thyroid gland identified during life is an uncommon cause of thyroid enlargement; usually, metastases are found at autopsy as part of widespread disease (2).…”

Section: Introductionmentioning

confidence: 99%

“…Although metastatic disease to the thyroid gland is rare, when it does occur kidney is the most common primary tumor site (3). Other primary sites include melanoma, lung, breast, esophagus, uterus and colon carcinoma (1). If metastatic renal cancer is limited to the thyroid gland only, prompt and appropriate surgical intervention can be curative (4).…”

Section: Introductionmentioning

confidence: 99%

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Thyroid Metastasis from Clear Cell Carcinoma of the Kidney 16 Years after Nephrectomy

et al. 2016

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The thyroid gland is one of the most vascularized organs in the body. However, metastatic disease to the thyroid gland is rare. When it does occur kidney is the most common primary tumor site, followed by melanoma, lung, breast, esophagus, uterus and colon carcinoma. We describe the case of an isolated thyroid metastasis from clear cell renal carcinoma occurring 16 years after nephrectomy. An 82 years-old woman presented for the recent growth of a right thyroid nodule, diagnosed 3 years before, when a fine needle aspiration biopsy found a benign cytology suggesting a well-differentiated follicular thyroid adenoma. Her medical history included type 2 diabetes mellitus, atrial fibrillation and a right nephrectomy for a clear cell renal carcinoma done 16 years before. The patient has lost weight but she was otherwise asymptomatic. The right lobe goiter was painless, firm, and mobile with deglutition, without signs of local compression or latero-cervical lymphadenopathy. Thyroid ultrasonography revealed an enlarged (9.9 cm) macronodular right lobe, with multiple cystic areas, with normal left lobe and a thrombus in the right internal jugular vein. Thyroid function tests were normal. The patient was suspected of thyroid carcinoma and underwent a near total thyroidectomy. Histopathological examination revealed a metastasis of clear cell renal carcinoma in the right thyroid gland lobe (8.5/5/5 cm). Further imaging showed no primary tumor or other metastases. Metastatic renal carcinoma to the thyroid should be considered in any patient presenting with a thyroid mass and a medical history of operated renal cell carcinoma, since it can occur up to 25 years after nephrectomy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thyroid Metastasis from Clear Cell Carcinoma of the Kidney 16 Years after Nephrectomy

et al. 2016

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“…8,10,11 Valdez et al reported a case of RCC metastatic to the thyroid 23 years after nephrectomy. 17 The median interval in our cases was 9.0 years, and the longest interval was 22 years. It is often difficult to diagnose MRCCT in patients with long disease-free intervals after nephrectomy.…”

Section: Discussionmentioning

confidence: 50%

Clinical, cytological, and pathological characteristics of metastatic renal cell carcinoma to the thyroid: A study of 14 cases at a Japanese single institution

Tanaka

Hirokawa

Suzuki

et al. 2023

Pathology International

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A preoperative diagnosis of metastatic renal cell carcinoma to the thyroid (MRCCT) is important for determining clinical management but is challenging even in cases with a clinical history of renal cell carcinoma (RCC). This study aimed to elucidate the clinical, cytological, and pathological characteristics of MRCCT. Fourteen MRCCT cases extracted from 18 320 malignant thyroid tumors were included in this study. Twelve MRCCT (85.7%) occurred as solitary lesions and the most frequently suspected lesions on ultrasonography were follicular tumors. On cytology, 46.2% of cases were reported as RCC or suspected RCC; a medical history of RCC and immunocytochemistry were helpful in interpretation. RCC metastasized to a follicular adenoma in 50.0% of the solitary lesions. MRCCTs with a long interval from the initial presentation, solitary lesion, and Ki‐67 labeling index <10% showed significantly longer disease‐free survival. MRCCT is characterized by a long interval from the initial presentation of RCC, appearance as a solitary nodule, ultrasonographic similarity to follicular tumors, sharing cytological findings with primary thyroid tumors, and high frequency of metastasis within follicular adenoma. A long interval from the initial presentation, occurrence as a solitary lesion, and low Ki‐67 labeling index may be favorable prognostic factors.

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“…But metastasis to thyroid gland is very rare. [1][2] If it is found then kidney is the most common primary site. Other primary sites from where metastasis to thyroid gland occurs are melanoma, lung, breast, esophagus, uterus and colon carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Tumor-to-tumor Metastases: Papillary Renal Cell Carcinoma into A Papillary Thyroid Carcinoma: A Case Report

et al. 2022

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Thyroid malignancies are commonest endocrine malignancy. It can be primary, can be secondary also.Though secondary thyroid malignancies are rare it happens sporadically from kidney, skin, breast andhead-neck tumor. Here we described a case of metastatic papillary thyroid carcinoma. This case wasdiagnosed as a case of papillary cell carcinoma of left kidney 18 months back, underwent radical nephrectomyand received a course of Tyrosine Kinase Inhibitor also and remain symptom free for one year. Thenpresented to us with thyroid swelling along with cervical lymphadenopathy. J MEDICINE 2022; 23: 77-81

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Metastatic Renal Cell Carcinoma to the Thyroid 23 Years After Nephrectomy

Cited by 7 publications

References 6 publications

Thyroid Metastasis from Clear Cell Carcinoma of the Kidney 16 Years after Nephrectomy

Thyroid Metastasis from Clear Cell Carcinoma of the Kidney 16 Years after Nephrectomy

Clinical, cytological, and pathological characteristics of metastatic renal cell carcinoma to the thyroid: A study of 14 cases at a Japanese single institution

Tumor-to-tumor Metastases: Papillary Renal Cell Carcinoma into A Papillary Thyroid Carcinoma: A Case Report

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