Metastatic Renal Cell Carcinoma to the Thyroid Gland

Duggal, Neal; Horattas, Mark C.

doi:10.4158/ep.14.8.1040

Cited by 38 publications

(26 citation statements)

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“…Metastatic nodules are found long after surgical resection of the primary mass, with the mean interval ranging from 6 to 12.5 years, and most patients present with no specific symptoms other than a palpable neck mass [1-3,6,8]. This is consistent with the characteristic behavior of RCC, in which recurrence occurs after a long latency period [10]. In our study, the mean interval between the initial RCC diagnosis and thyroid metastasis was 9.6±5.5 years, and all patients presented with no symptoms other than a palpable neck mass.…”

Section: Discussionmentioning

confidence: 63%

Metastatic renal cell carcinoma in the thyroid gland: ultrasonographic features and the diagnostic role of core needle biopsy

et al. 2017

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PurposeThe aims of this study were to present the ultrasonographic (US) features of metastatic renal cell carcinoma (RCC) in the thyroid gland and to evaluate the diagnostic utility of fineneedle aspiration (FNA) and core needle biopsy (CNB).MethodsEight patients with nine metastatic RCC nodules in the thyroid glands who were treated from January 2002 to March 2015 in a single tertiary hospital were consecutively selected and retrospectively reviewed. US features and clinical history were obtained from the institution’s medical database. FNA was performed nine times on eight nodules and CNB was performed six times on six nodules. The diagnostic utility of FNA and CNB was evaluated.ResultsAll nine nodules showed mass formation without diffuse thyroid involvement. On ultrasonography, metastatic RCC nodules were solid (100%), hypoechoic (100%), and ovalshaped nodules with a well-defined smooth margin (88.9%) and increased vascularity (100%, with 55% showing extensive vascularity). No calcifications were noted in any nodules. Lymph node metastasis and direct extension to nearby structures beyond the thyroid gland were not found. One FNA (11%) was able to confirm metastatic RCC, whereas all six CNBs confirmed metastatic RCC.ConclusionMetastatic RCC appears as oval-shaped hypoechoic solid nodules with well-defined smooth margins, no calcifications, and increased vascularity on ultrasonography. Characteristic US features along with a previous history of RCC should raise clinical suspicion, and CNB should be performed to make an accurate diagnosis.

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Section: Discussionmentioning

confidence: 63%

Metastatic renal cell carcinoma in the thyroid gland: ultrasonographic features and the diagnostic role of core needle biopsy

et al. 2017

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“…It has been reported to constitute one-third to half of all the causes for thyroid metastases [5], [7]. This has most commonly been reported to occur late in the disease, with a mean interval of 7.5 years after initial diagnosis [4]. According to Duggal et al.…”

Section: Discussionmentioning

confidence: 99%

“…According to Duggal et al. [4], almost 150 cases of clinically recognized metastatic RCC to the thyroid have been reported in the English language literature. Clear-cell variant of RCC has been reported to most commonly metastasize to the thyroid as well [3], [4], [5], [6].…”

Section: Discussionmentioning

confidence: 99%

“…The metastatic pathways for RCC are not always foreseeable, but most common sites of metastases include lungs, brain, bone and/or bone marrow [1]. Metastatic involvement of the thyroid gland from RCC is extremely rare [3], [4], [5], [6], [7]. RCC metastases to the thyroid gland have been previously reported as a solitary mass only, without report of diffuse metastatic involvement in the existing literature [3], [4], [6].…”

Section: Introductionmentioning

confidence: 99%

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Diffuse thyroid metastases and bilateral internal jugular vein tumor thrombus from renal cell cancer

Jha

Shekhar

Wan

et al. 2016

Radiology Case Reports

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Renal cell cancer rarely metastasizes to the thyroid gland, and it has been reported to present as a solitary mass. We present a case of diffuse thyroid cancer metastases from renal cell cancer. Bilateral internal jugular vein tumor thrombi were also present. To the best of our knowledge, this is the first description of diffuse thyroid metastases from renal cell cancer in the English literature. Renal cell cancer metastases should be considered in the differential of thyroid imaging abnormalities arising in the setting of known renal cell carcinoma, particularly late in the course of disease. This is frequently associated with internal jugular vein thrombi, which should be evaluated with an abnormal thyroid. Thyroglobulin levels are usually normal in such patients.

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“…У мужчин рак почки развивается чаще, чем у женщин (соответственно 4,7 и 3,3 %, или 7-е и 9-е места [1,3]). Метастатическое поражение щитовидной железы является редким случаем, хотя эта железа после надпо-чечников наиболее васкуляризирована [4][5][6][7][8]. В лите-ратуре этот факт объясняют, ссылаясь на гипотезу R. Willis (1931), согласно которой быстрый ток крови через щитовидную железу препятствует прилипанию опухолевых клеток и, кроме того, высокое содержание кислорода и йода тормозит развитие злокачественных клеток [9].…”

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Metastases of kidney cancer into the thyroid gland (сlinical observation)

Огнерубов¹,

Барсуков²,

Chang³

et al. 2017

Opuholi golovy šei

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Key words: thyroid gland, metastases, renal cell carcinomaВведение Рак почки составляет 3,9 % от общего числа онко-логической патологии [1] и 90 % всех злокачественных новообразований почки [2]. Пик заболеваемости при-ходится на 50-60 лет. У мужчин рак почки развивается чаще, чем у женщин (соответственно 4,7 и 3,3 %, или 7-е и 9-е места [1,3]).Метастатическое поражение щитовидной железы является редким случаем, хотя эта железа после надпо-чечников наиболее васкуляризирована [4][5][6][7][8]. В лите-ратуре этот факт объясняют, ссылаясь на гипотезу R. Willis (1931), согласно которой быстрый ток крови через щитовидную железу препятствует прилипанию опухолевых клеток и, кроме того, высокое содержание кислорода и йода тормозит развитие злокачественных клеток [9].Так, H. Chen и соавт. (1999) при ретроспективном исследовании выявили за 8 лет только 10 случаев ме-тастатического поражения щитовидной железы в 1 уч-реждении [10]. K. Kobayashi и соавт. (2015) 15 лет на-блюдали 10 пациентов с метастатическим раком щитовидной железы при почечно-клеточном раке [11]. В клинике Мейо за период в 55 лет выявлено 14 паци-ентов с аналогичной патологией [12].О метастатическом поражении щитовидной желе-зы сообщается в 1,4-3 % случаев среди всех операций на этом органе [13][14][15][16][17][18]. Причем среди всех злокаче-ственных новообразований чаще всего метастазируют опухоли почки (48,1 %), колоректальный рак (10,4 %), рак легких (8,3 %), рак молочной железы (7,8 %), ме-ланома (4 %) и саркома (4 %) [17,[19][20][21]. Но по ре-зультатам вскрытий частота метастазирования коле-

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Metastatic Renal Cell Carcinoma to the Thyroid Gland

Cited by 38 publications

References 44 publications

Metastatic renal cell carcinoma in the thyroid gland: ultrasonographic features and the diagnostic role of core needle biopsy

Metastatic renal cell carcinoma in the thyroid gland: ultrasonographic features and the diagnostic role of core needle biopsy

Diffuse thyroid metastases and bilateral internal jugular vein tumor thrombus from renal cell cancer

Metastases of kidney cancer into the thyroid gland (сlinical observation)

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