Metastatic renal cell carcinoma of the native kidney in a renal transplant recipient: Revisiting the era of tyrosine kinase inhibitors – Case report

Suso-Palau, Daniel; Soto, Julián Chavarriaga; Usubillaga, Francisco; Asprilla, Josué; Micolta, Lina; Urrego, Marcela

doi:10.1016/j.eucr.2022.102082

Cited by 3 publications

(2 citation statements)

References 5 publications

(34 reference statements)

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“…There is currently no consensus on this dilemma. Reduction of immunosuppression drug dose and/or switch to mammalian target of rapamycin inhibitor, graftectomy, and complete withdrawal of immunosuppression, immune checkpoint inhibitors, or tyrosine kinase inhibitor are all possible options ( 30 – 32 ). Shared decision-making involving the urologist, oncologist, transplant specialist, and patient is essential to develop a rational treatment strategy.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

Renal cell carcinoma of different pathological types in bilateral native kidneys of a kidney transplant recipient: A case report and literature review

You²,

Sha³

et al. 2023

Front. Oncol.

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Patients after kidney transplantation have a much higher risk of developing malignant tumors than the general population. And the native kidney is an organ relatively susceptible to malignant tumors after renal transplantation. However, the simultaneous development of bilateral renal tumors is very rare; especially the bilateral native kidneys harbor different pathological types of renal cell carcinoma (RCC). We report a case of a patient who developed malignant tumors in both native kidneys nearly 19 years after renal transplantation. This patient underwent bilateral laparoscopic radical nephrectomy, and postoperative pathological examination showed clear cell RCC on the left native kidney and papillary RCC on the right one. And the early detection and surgical treatment resulted in a good prognosis. The literature related to the diagnosis and treatment of bilateral RCC after renal transplantation is also reviewed.

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Section: Literature Review and Discussionmentioning

confidence: 99%

Renal cell carcinoma of different pathological types in bilateral native kidneys of a kidney transplant recipient: A case report and literature review

You²,

Sha³

et al. 2023

Front. Oncol.

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“…[9][10][11] However, some examples with distant metastasis are reported but none of them into the renal allograft. 9,[11][12][13][14][15][16] Also, tumours of other origin than kidney seem to rarely metastasize into the allograft in kidney transplant recipients. We could only find one single report of a metastatic allograft lesion originating from a urothelial carcinoma of the recipient.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Translocated Renal Cell Carcinoma in a Kidney Transplant Patient - a Case Report and Review of the Literature

et al. 2023

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TFEB-altered renal cell carcinomas are rare tumours. Here, we report the exceptional case of such a tumour in the setting of solid organ transplantation and with already metastatic disease at the time of diagnosis. The primary tumour occurred in the native kidney and only focally showed biphasic morphology whereas the metastasis, among others to the transplant kidney, showed nonspecific, albeit different morphology, but both had consistent TFEB translocation. Treatment with the immune checkpoint inhibitor pembrolizumab together with the multi-kinase inhibitor lenvatinib achieved partial response 14 months after diagnosis.

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Ciclosporin

2022

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Metastatic renal cell carcinoma of the native kidney in a renal transplant recipient: Revisiting the era of tyrosine kinase inhibitors – Case report

Cited by 3 publications

References 5 publications

Renal cell carcinoma of different pathological types in bilateral native kidneys of a kidney transplant recipient: A case report and literature review

Renal cell carcinoma of different pathological types in bilateral native kidneys of a kidney transplant recipient: A case report and literature review

Metastatic Translocated Renal Cell Carcinoma in a Kidney Transplant Patient - a Case Report and Review of the Literature

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