Metastatic Renal Cell Carcinoma Mimicking a Meningioma

Killebrew, Kate; Krigman, Martin R.; Mahaley, M. S.; Scatliff, James H.

doi:10.1227/00006123-198310000-00015

Cited by 32 publications

(5 citation statements)

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“…According to some authors, the finding of an extensive perilesional edema is more characteristic of metastases than other intraventricular lesions 51–54. However, other authors have reported that intraventricular metastases can mimic meningiomas or colloid cysts 55,56…”

Section: Discussionmentioning

confidence: 99%

Endoscopy-verified occult subependymal dissemination of glioblastoma and brain metastasis undetected by MRI: prognostic significance

Iacoangeli¹,

Rienzo²,

Colasanti³

et al. 2012

OTT

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Although various prognostic indices exist for patients with malignant brain tumors, the prognostic significance of the subependymal spread of intracranial tumors is still a matter of debate. In this paper, we report the cases of two intraventricular lesions, a recurrent glioblastoma multiforme (GBM) and a brain metastasis, each successfully treated with a neuroendoscopic approach. Thanks to this minimally invasive approach, we achieved good therapeutic results: we obtained a histological diagnosis; we controlled intracranial hypertension by treating the associated hydrocephalus and, above all, compared with a microsurgical approach, we reduced the risks related to dissection and brain retraction. Moreover, in both cases, neuroendoscopy enabled us to identify an initial, precocious subependymal tumor spreading below the threshold of magnetic resonance imaging (MRI) detection. This finding, undetected in pre-operative MRI scans, was then evident during follow-up neuroimaging studies. In light of these data, a neuroendoscopic approach might play a leading role in better defining the prognosis and optimally tailored management protocols for GBM and brain metastasis.

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Section: Discussionmentioning

confidence: 99%

Endoscopy-verified occult subependymal dissemination of glioblastoma and brain metastasis undetected by MRI: prognostic significance

Iacoangeli¹,

Rienzo²,

Colasanti³

et al. 2012

OTT

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“…A group of entities mimicking TM includes choroid plexus metastases of renal cell carcinoma with[16] or without[2445] intraventricular hemorrhage, glioblastoma multiforme,[49] and cavernous malformations. [1926]…”

Section: Discussionmentioning

confidence: 99%

Intraventricular trigonal meningioma: Neuronavigation? No, thanks!

Do¹,

Gk²,

Lf³

et al. 2011

Surg Neurol Int

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Background:Most of the time meningiomas are benign brain tumors and surgical removal ensures cure in the vast majority of the cases. Thus, whenever possible, complete surgical resection should be the goal of the treatment.Methods:This is a report of our surgical technique for the operative resection of a trigonal meningioma in a resource-limited setting. The necessity of accurate and deep knowledge of the regional anatomy is outlined.Results:A 44-year-old male presented to our outpatient clinic complaining of cephalalgia increasing in frequency and intensity over the last month. His neurological exam was normal, yet a brain computed tomography scan revealed a lesion in the right trigone of the ventricular system. The diagnosis of possible meningioma was set. After thoroughly informing the patient, tumor resection was decided. An intraparietal sulcus approach was favored without the use of any modern technological aids such as intraoperative magnetic resonance imaging or neuronavigation. The postoperative course was uneventful and a postoperative computed tomography scan demonstrated the complete resection of the tumor. The patient was discharged two days later with no neurological deficits. In a two-year-follow-up he remains recurrence-free.Conclusion:In the current cost-effective era it is still possible to safely remove an intraventricular trigonal meningioma without the convenience of neuronavigation. Since the best neuronavigator is the profound neuroanatomical knowledge, no technological advancement could replace a well-educated and trained neurosurgeon.

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“…Many cases of late brain metastases from RCC have been described in the literature;[ 1 , 2 , 6 , 9 , 11 , 12 , 14 , 15 , 16 , 20 , 21 , 25 , 27 ] however, few of them analyze the pathophysiology of the appearance of these metastases. The objective of this work is to discuss which biological pathways are responsible for the late appearance of these metastases analyzing eight cases.…”

Section: Introductionmentioning

confidence: 99%

Which biological pathways are responsible for the late appearance of brain metastases in renal cell carcinoma? Analysis of eight cases

Minghinelli

Recalde

Prost

et al. 2022

Surgical Neurology International

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Background: Renal cell carcinoma (RCC) represents 1% of all cancers and its brain metastases amount to 8.1% of all metastatic tumors. Late brain metastases are defined as tumors that appear 10 years after diagnosis of the primary lesion. The objective of this work is to discuss which biological pathways are responsible for the late appearance of these metastases analyzing eight cases. Case Description: We report here eight cases of late brain metastases of RCC treated between 2018 and 2021. Patients consulted for different clinical complaints. Brain magnetic resonance imaging and computed tomography scan were performed on all patients. They were treated by complete surgical resection plus radiosurgery or by radiosurgery alone. The histology of most metastases showed clear cell RCC. Conclusion: In the presence of a patient with an intracranial tumor and a history of RCC with more than 10 years of evolution, the presence of late metastasis should always be considered. There are many theories described in the literature that try to explain the late appearance of brain metastases from RCC (low mitotic index, impaired immune system, cross talk, self-seeding, and among others).

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Metastatic Renal Cell Carcinoma Mimicking a Meningioma

Cited by 32 publications

References 0 publications

Endoscopy-verified occult subependymal dissemination of glioblastoma and brain metastasis undetected by MRI: prognostic significance

Endoscopy-verified occult subependymal dissemination of glioblastoma and brain metastasis undetected by MRI: prognostic significance

Intraventricular trigonal meningioma: Neuronavigation? No, thanks!

Which biological pathways are responsible for the late appearance of brain metastases in renal cell carcinoma? Analysis of eight cases

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