Metastatic Renal Cell Carcinoma in a Hepatic Hemangioma

Abstract

We report the case of 55-year-old female with biopsy-proven clear cell renal cell carcinoma with a suspicious lesion found in the liver who presented for right radical nephrectomy and partial hepatectomy. Histologic evaluation of the hepatic specimen demonstrated metastatic renal cell carcinoma within a hepatic hemangioma. Herein we provide a review of the literature for this uncommon scenario.

Renal cell carcinoma metastasis to a hepatic haemangioma: a wolf in sheep's clothing

“…In this reported case, as the liver lesion predated the diagnosis and treatment of clear cell renal carcinoma by 4 years, it is likely that the renal carcinoma metastasized to a pre‐existing hepatic haemangioma. Only one other reported case exists of a renal cell carcinoma metastasis within a hepatic haemangioma 1 . However, in this report, as the lesions were synchronously detected, the authors hypothesized that the renal carcinoma may have induced the development of a hepatic haemangioma through activation of the vascular endothelial growth factor pathway.…”