“…10 However, approximately 60-76% of patients who undergo an R0 resection will develop recurrence, despite advances in staging, adjuvant therapy, and surgical approaches. 4,6,11 For a better understanding of the prognostic factors that determine recurrence, histopathological features have been identified in the primary tumour, such as pTNM staging, vascular invasion, lymphatic invasion, perineural invasion, tumour grade, tumour deposits, tumour budding, tumour border configuration, tumour perforation, histological type, and inflammatory infiltration. 12,13 Pathologists routinely report these criteria for the primary tumour, in order to guide oncologists in the decision-making regarding adjuvant systemic therapy.…”