Metastatic Pulmonary Artery Sarcoma

Medalie, Neil S.; Vallejo, Christine E.; Wasserman, Patricia

doi:10.1159/000331978

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…In conclusion, due to the aggressive nature of pulmonary artery intimal sarcoma, rapid recognition is needed in order to decrease the time between diagnosis and treatment [ 4 ]. CT, PET, and EBUS-guided needle aspiration along with immunohistochemical staining are useful in the rapid diagnosis of pulmonary artery intimal sarcoma.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of this tumor is 0.001–0.03%, however, it may be underestimated due to misdiagnosis as chronic pulmonary thromboembolism [ 3 ]. The prognosis is very poor, so rapid accurate diagnosis is imperative for early effective treatment [ 4 ]. Here, we report the case of a 72-year-old African-American retired bus driver with pulmonary artery intimal sarcoma.…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary Artery Intimal Sarcoma: A Case Report

Kriz¹,

Munfakh²,

King³

et al. 2016

Case Rep Oncol

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Pulmonary artery intimal sarcomas are rare and lethal malignant tumors that typically affect larger vessels: the aorta, inferior vena cava, and pulmonary arteries. Since symptoms and imaging of pulmonary arterial intimal sarcomas mimic pulmonary thromboembolism, the differential diagnosis of a patient presenting with chest pain, dyspnea, and filling defect within the pulmonary arteries should include intimal sarcoma. Often right ventricular failure is observed due to pulmonary hypertension caused by the obstructive effect of the tumor and concomitant chronic thromboembolism. We report the case of a 72-year-old African-American male with arterial intimal sarcoma of the left and right pulmonary artery with extension through the right artery into the bronchus and right lung.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pulmonary Artery Intimal Sarcoma: A Case Report

Kriz¹,

Munfakh²,

King³

et al. 2016

Case Rep Oncol

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“…Medalie et al . [ 9 ] described the cytomorphologic features in the case of metastatic PAS to the lung diagnosed by FNA. The aspirate showed single and loosely cohesive clusters of pleomorphic and spindled malignant cells that were embedded in an extracellular metachromatic matrix.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] However, these tumors occasionally show specific cellular differentiation on morphology with or without immunophenotyping. [ 3 4 5 ] Only a few case reports describe the use of fine-needle aspiration (FNA) in evaluating these lesions,[ 9 10 11 ] and only one study describes the cytomorphologic features in a metastatic lesion. [ 9 ]…”

Section: Introductionmentioning

confidence: 99%

Pulmonary artery intimal sarcoma diagnosed using endobronchial ultrasound-guided transbronchial needle aspiration

et al. 2015

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Intimal sarcoma of the pulmonary artery is a rare intraluminal malignant neoplasm that has an aggressive biological behavior, and early diagnosis may improve patient outcome. We describe a case of pulmonary artery intimal sarcoma diagnosed on cytologic material obtained by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) biopsy with rapid on-site evaluation (ROSE). The aspirate showed loosely cohesive clusters of pleomorphic malignant spindled and epithelioid cells. An immunostain panel did not demonstrate any definitive mesenchymal or epithelial differentiation. The tumor's intraluminal origin was supported by radiographic imaging studies. Subsequently, the patient received preoperative chemotherapy and underwent tumor resection with reconstruction. This report describes the cytomorphologic features of this rare intravascular tumor and demonstrates how EBUS-TBNA with ROSE was instrumental in obtaining optimal cytologic sampling for ancillary studies, thus expediting the management.

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“…Pulmonary artery sarcomas (PAS) are rare tumors with varying presentations including pulmonary artery obstruction, pulmonary hypertension, and intrathoracic or extrathoracic metastasis [1].Metastatic pulmonary sarcomas are even more uncommon, and to our knowledge, have only been reported in one case [2]. We report this case to highlight a novel presentation of this tumor and to discuss the challenge in using different treatment modalities.…”

Section: Introductionmentioning

confidence: 99%