Metastatic Prostate Carcinoma Presenting as Numb Chin Syndrome in Elderly People

Requena, Ana; Riera‐Mestre, Antoni; Formiga, Francesç; Vidaller, Antonio; Pujol, R.

doi:10.1111/j.1532-5415.2008.01599.x

Cited by 11 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although relatively rare signs and symptoms, when they do present, they are known collectively as numb chin, and are most often a prodromal sign of a serious malady, as in the 439 cases (76%) in the present review. Numb chin turned out to be the prodromal sign and was the initial manifestation of acute lymphoblastic leukemia (ALL) of the B-cell type, Burkitt's-type ALL, other types of leukemia, malignant lymphoma, breast cancer, prostate cancer, other types of cancers, metastatic, and systemic diseases, and even HIV/AIDS [3,7,12,14,[17][18][19][20][21][22][23]25,28,[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47]. Henny C et al cautioned, although benign in appearance, NCS is most often associated with visceral neoplasia or malignant hemopathy and a factor of poor prognosis [48].…”

Section: Discussionmentioning

confidence: 99%

Numb Chin Syndrome with Four Fulminant Attacks in 16 Years

2018

J Syndr

View full text Add to dashboard Cite

We present a case report of an otherwise healthy 68-year-old man with a 16-year follow-up of recurrent sudden and severe attacks of painful but benign numb chin syndrome (NCS).The patient presented with only one subjective finding: recurrent mental nerve neuropathy, a periodic, localized, atypical facial pain continuing up to 2 weeks at a time. Undergoing tests on an outpatient basis, a complete lab work-up including dental examination and laboratory tests, electroencephalogram, chest x-ray, abdominal ultrasonography, head and neck magnetic resonance imaging and computed tomography were done.All examinations and test results were within normal limits and with no remarkable findings in 16 years of follow-up. After family, social, surgical, medical, dental, and psychological histories, with appropriate and careful clinical work-ups, no definitive diagnoses, other than NCS, could be made. An extensive literature search in the PubMed interface using the key words, "numb chin syndrome," "mental neuropathy," and "mental nerve numbness," revealed 152 articles reporting 576 patients. As reported, NCS can be benign or a precursor of certain cancers, leukemia, other morbidity, and mortality. Though inconveniencing and embarrassing, painful and extremely worrying during the periods of infliction, the present case of NCS has been benign for 16 years.

show abstract

Section: Discussionmentioning

confidence: 99%

Numb Chin Syndrome with Four Fulminant Attacks in 16 Years

2018

J Syndr

View full text Add to dashboard Cite

show abstract

“…Th ere is no loss of motor function, as the inferior alveolar nerve contains no motor fi bers. While associated with certain benign etiologies (1-3), the condition is increasingly reported as a manifestation of malignancy, including prostate adenocarcinoma (4,5), lymphoma and leukemia (6)(7)(8), multiple myeloma (9), and breast cancer (10). While many of these malignancies are associated with other historical or physical signs or symptoms, numb chin often presents as the initial symptom (11)(12)(13)(14)(15), and awareness of this physical fi nding should raise suspicion for an underlying malignancy and may even contribute to earlier detection.…”

Section: Numb Chin Syndrome As the Initial Presentation Of Posttranspmentioning

confidence: 99%