Metastatic potential

Ceafalan, Laura Cristina; Niculae, Andrei Marian; Ioghen, Octavian Costin; Gherghiceanu, Mihaela; Hinescu, Mihail Eugen

doi:10.1016/b978-0-12-821789-4.00005-9

Cited by 1 publication

(1 citation statement)

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“…A marginally significant prognostic CD36 value, with high expression associated with poorer prognoses, was identified, as previously suggested in a smaller gene expression study on CRC [16]. Other studies have emphasized the critical role of CD36 in promoting the cellular proliferation, progression, and metastasis of primary CRC and other cancers [17][18][19]. Moreover, it has recently been demonstrated that CD36 can regulate glycolysis and tumorigenesis in CRC through the ubiquitination of the cell surface proteoglycan glypican 4 (GPC4).…”

Section: Introductionsupporting

confidence: 54%

Lipid Handling Protein Gene Expression in Colorectal Cancer: CD36 and Targeting miRNAs

Niculae

Dobre

Herlea

et al. 2022

Life

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Th reprogramming of lipid metabolism has been highlighted in colorectal cancer (CRC) studies, suggesting a critical role for the scavenger receptor CD36 and fatty acid synthase (FASN) in this malignancy. In this study, we analyzed the gene expression levels of CD36, FASN, the cell surface glypican 4 (GPC4), and the two transporters SLC27A3 and SLC27A4 in 39 paired tumoral and peritumoral tissues from patients with CRC compared with 18 normal colonic mucosae. Moreover, the levels of seven miRNAs targeting CD36 and most of the analyzed genes were evaluated. We found a significant impairment of the expression of all the analyzed genes except GPC4 as well as the differential expression of miR-16-5p, miR-26b-5p, miR-107, miR-195-5p, and miR-27a-3p in the colonic mucosa of CRC patients. Interestingly, CD36 and miR-27a-3p were downregulated and upregulated, respectively, in tumoral tissues compared to peritumoral and control tissues, with a significant negative correlation in the group of patients developing lymph node metastasis. Our results sustain the relationship between CRC and fatty acid metabolism and emphasize the importance of related miRNAs in developing new therapeutic strategies.

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