Metastatic Parathyroid Carcinoma to the Liver Treated With Radiofrequency Ablation and Transcatheter Arterial Embolization

Artinyan, Avo; Guzman, Eduardo A.; Maghami, Ellie; Al-Sayed, Mohammed H.; D’Apuzzo, Massimo; Wagman, Lawrence D.; Kim, Joseph

doi:10.1200/jco.2007.15.9038

Cited by 28 publications

(18 citation statements)

References 17 publications

(10 reference statements)

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“…Embolisation of localised and/or ectopic parathyroid adenomas has been reported to have only limited success [19, 25–27], and in metastatic parathyroid carcinoma, embolisation has only been described in combination with RF ablation in one patient [19]. In our patient, the outcome of twice attempted embolisation of a lung metastasis was disappointing, largely because it was not technically possible to selectively embolise the arterial branch that fed the lung metastasis.…”

Section: Discussionmentioning

confidence: 86%

“…The most effective treatment for parathyroid carcinoma is radical surgery with en bloc removal of the lesion together with the ipsilateral thyroid, thyroid isthmus and lymph nodes [2, 3, 5, 13, 15]. Surgery is also the treatment of choice in case of local recurrence or development of metastases [5, 7, 16], although radiotherapy [2–5, 8, 9], chemotherapy [3, 5, 9, 17, 18], embolisation [19] or radio frequency (RF) ablation [19–21] may also be attempted.…”

Section: Introductionmentioning

confidence: 99%

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Challenges and Pitfalls in the Management of Parathyroid Carcinoma: 17-Year Follow-Up of a Case and Review of the Literature

et al. 2010

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A 29-year-old man presented to his primary care physician with nausea, severe weight loss and muscle weakness. He had a hard, fixed neck swelling. He was severely hypercalcaemic with 10-fold increased parathyroid hormone (PTH) concentrations. A diagnosis of primary hyperparathyroidism was established and the patient was referred for parathyroidectomy. At neck exploration, an enlarged parathyroid gland with invasive growth into the thyroid gland was found and removed, lymph nodes were cleared and hemithyroidectomy was performed. A suspected diagnosis of parathyroid carcinoma was confirmed histologically. Serum calcium and PTH levels normalised post-operatively, but hyperparathyroidism recurred within 3 years of surgery. Over the following 17 years, control of hypercalcaemia represented the most difficult challenge despite variable success achieved with repeated surgical interventions, embolisations, radiofrequency ablation of metastases and treatment with calcimimetics, bisphosphonates and haemodialysis using low-dialysate calcium. In this paper, we report the challenges and pitfalls we encountered in the management of our patient over nearly two decades of follow-up and review recent literature on the topic.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Challenges and Pitfalls in the Management of Parathyroid Carcinoma: 17-Year Follow-Up of a Case and Review of the Literature

et al. 2010

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“…A patient with multiple hepatic metastases was treated with a combination of radiofrequency ablation and arterial embolization [85]. A patient with PC due to recurrent HPT resulting from many dozens of pulmonary metastases was treated with multiple sessions of radiofrequency ablation [86].…”

Section: Interventional Radiologic Therapiesmentioning

confidence: 99%

Parathyroid Cancer and the CDC73 Tumor Suppressor Gene

Simonds¹

2014

Int. J. Endo. Oncol.

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Parathyroid carcinoma (PC) is a rare endocrine neoplasm, usually causing severe primary hyperparathyroidism, that frequently causes death from unmanageable hypercalcemia. PC is frequently associated with somatic inactivating mutations of the CDC73 gene (previously called HRPT2), a gene discovered in association with the familial hyperparathyroidism-jaw tumor syndrome. DNA analysis for CDC73 mutation should be performed on all patients with seemingly sporadic PC since some 25% will carry a germline mutation. It is often difficult to make a firm diagnosis of PC by histopathology alone. That diagnosis often depends on the presence of local tissue invasion or distant metastases. If PC is suspected, en bloc resection at initial surgery is recommended. Medical therapy with cinacalcet, bisphosphonates or denosumab may temporarily ameliorate the hypercalcemia of inoperable PC.

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“…Cytotoxic chemotherapy is used even less frequently than external beam radiation therapy, and only isolated reports with very small numbers of patients exist [37,38]. Reports of successful radiofrequency embolization or transarterial catheter embolization of distant metastatic disease exist, but the number of cases in which it has been used is limited [39,40].…”

Section: Adjuvant Treatmentmentioning

confidence: 99%

Current and Future Treatments for Parathyroid Carcinoma

Long

Sippel

2018

Int. J. Endo. Oncol.

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Parathyroid carcinoma (PC) is a rare disease and presents clinical challenges in diagnosis, management and adjuvant treatment. Rarely diagnosed preoperatively, PC is often discovered in the treatment of primary hyperparathyroidism. PC is predominantly treated surgically with minimal additional treatments available. Given the rarity of the disease, current and future efforts, as discussed in this article, are focused on increasing preoperative diagnosis, recognizing genetic patterns and pathologic markers and delineating nonsurgical options for patients with advanced disease.

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Metastatic Parathyroid Carcinoma to the Liver Treated With Radiofrequency Ablation and Transcatheter Arterial Embolization

Cited by 28 publications

References 17 publications

Challenges and Pitfalls in the Management of Parathyroid Carcinoma: 17-Year Follow-Up of a Case and Review of the Literature

Challenges and Pitfalls in the Management of Parathyroid Carcinoma: 17-Year Follow-Up of a Case and Review of the Literature

Parathyroid Cancer and the CDC73 Tumor Suppressor Gene

Current and Future Treatments for Parathyroid Carcinoma

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