Metastatic Ovarian Adenocarcinoma in a Dog Treated with Ovariohysterectomy and Intracavitary Chemotherapy

Itoh, Teruo; Uchida, Katsuhisa; Kojimoto, Atsuko; Ikeda, Ayako; Nibe, Kazumi; Shii, Hiroki

doi:10.2327/jvas.38.63

Cited by 4 publications

(2 citation statements)

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“…In the present study, 3 cases of ovarian papillary adenocarcinoma presented with ascites and pleural effusion, which resolved after ovariectomy. Similar conditions were also reported in previous canine cases of ovarian papillary adenocarcinoma [ 12 , 13 , 14 , 21 ]. The phenomena are thought to be associated with Meigs or pseudo-Meigs syndrome in veterinary medicine.…”

Section: Discussionsupporting

confidence: 88%

“…However, these markers have not been examined in canine ovarian papillary adenocarcinoma. Dogs with ovarian papillary adenocarcinoma occasionally present with ascites and/or pleural effusions [4,12,13,14,21]. Aspirated fluid contains a large number of cells, that may consist of neoplastic epithelial cells, activated mesothelial cells and inflammatory cells.…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical features of canine ovarian papillary adenocarcinoma and utility of cell block technique for detecting neoplastic cells in body cavity effusions

Kita

Chambers

Tanabe³

et al. 2022

The Journal of Veterinary Medical Science

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Dogs with ovarian papillary adenocarcinoma occasionally present with ascites and/or pleural effusion. These aspirated fluids often contain a large number of cells, and distinction between neoplastic cells and activated mesothelial cells can be difficult. In this study, 7 cases of canine ovarian papillary adenocarcinoma, including 3 with ascites and pleural effusion, were immunohistochemically examined. Ovarian tumor cells were positive for cytokeratin CAM5.2 (CAM5.2), Wilms' tumor 1 (WT-1) and progesterone receptor (PR) in all 7 cases. A metastatic lesion of the mediastinum in one case was also positive for CAM5.2, WT-1 and PR. Immunohistochemistry on cell blocks obtained from ascites and/or pleural effusion of 2 cases revealed the presence of PR-positive epithelial cells. Whereas, activated mesothelial cells in ascites or pleural effusion collected from dogs without neoplastic lesions were negative for PR. In addition, surface epithelium and subsurface epithelial structures (SES) of normal canine ovaries, that are considered to be the cell of origin for ovarian papillary adenocarcinoma, were also positive for CAM5.2, WT-1 and PR. These results indicate that, together with CAM5.2, WT-1 and PR is a useful diagnostic marker for canine ovarian papillary adenocarcinoma. Expression of PR may be associated with progesterone-dependent nature of canine ovarian papillary adenocarcinoma.

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