Metastatic Non-Small Cell Lung Cancer in Brazil: Treatment Heterogeneity in Routine Clinical Practice

Naime, Fauzia F.; Younes, Riad Naim; Kersten, Bruno G.; Anelli, Agnaldo; Beato, C.; Andrade, Rogério M.; Carrara, Marcella P.; Gross, Jefferson Luiz

doi:10.1590/s1807-59322007000400005

Cited by 18 publications

(16 citation statements)

References 17 publications

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“…In these patients, surgical resection of lung metastases may significantly impact long-term survival 3. We have recently reported on metastatic lung cancer in Brazil4 and reviewed possible sources of new anti-tumoral drugs from Brazilian plant extracts 5…”

Section: Introductionmentioning

confidence: 99%

Surgical Resection of Lung Metastases: Results from 529 Patients

Younes

Gross

Taira

et al. 2009

Clinics

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Younes RN, Gross JL, Taira AM, Martins AAC, Neves GS. Surgical resection of lung metastases: results from 529 patients. Clinics. 2009;64(6):535-41. OBJECTIVE:The aim of this study is to determine clinical, pathological, and treatment-relevant variables associated with longterm (90-month) overall survival in patients with lung metastases undergoing pulmonary metastasectomy. METHODS: A retrospective review was performed of patients who were admitted with lung metastases, and who underwent thoracotomy for resection, after treatment of a primary tumor. Data were collected regarding demographics, tumor features, treatment, and outcome. RESULTS: Patients (n = 529) were submitted to a total of 776 thoracotomies. Median follow-up time across all patients was 21.6 months (range: 0-192 months). The postoperative complication rate was 9.3%, and the 30-day mortality rate was 0.2%. The ninetymonth overall survival rate for all patients was 30.4%. Multivariate analysis identified the number of pulmonary nodules detected on preoperative CT-scan, the number of malignant nodules resected, and complete resection as the independent prognostic factors for overall survival. CONCLUSION: These results confirm that lung metastasectomy is a safe and potentially curative procedure for patients with treated primary tumors. A select group of patients can achieve long-term survival after resection.

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Section: Introductionmentioning

confidence: 99%

Surgical Resection of Lung Metastases: Results from 529 Patients

Younes

Gross

Taira

et al. 2009

Clinics

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“…In order to get a better target therapy, researchers have tried to identify key differences between lung cancer cells and normal lung cells, such as mutation or overexpression of genes, including EGFR, ras , and VEGF [37]–[39]. Unfortunately, current chemotherapies for lung cancer lack adequate specificity, efficacy, and treatment heterogeneity is also a big issue [40]. There is therefore an urgent need for new therapeutic drugs or new combinations of drugs to provide more efficient lung cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Sulindac Compounds Facilitate the Cytotoxicity of β-Lapachone by Up-Regulation of NAD(P)H Quinone Oxidoreductase in Human Lung Cancer Cells

Kung

Weng²,

Liu³

et al. 2014

PLoS ONE

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β-lapachone, a major component in an ethanol extract of Tabebuia avellanedae bark, is a promising potential therapeutic drug for various tumors, including lung cancer, the leading cause of cancer-related deaths worldwide. In the first part of this study, we found that apoptotic cell death induced in lung cancer cells by high concentrations of β-lapachone was mediated by increased activation of the pro-apoptotic factor JNK and decreased activation of the cell survival/proliferation factors PI3K, AKT, and ERK. In addition, β-lapachone toxicity was positively correlated with the expression and activity of NAD(P)H quinone oxidoreductase 1 (NQO1) in the tumor cells. In the second part, we found that the FDA-approved non-steroidal anti-inflammatory drug sulindac and its metabolites, sulindac sulfide and sulindac sulfone, increased NQO1 expression and activity in the lung adenocarcinoma cell lines CL1-1 and CL1-5, which have lower NQO1 levels and lower sensitivity to β-lapachone treatment than the A549 cell lines, and that inhibition of NQO1 by either dicoumarol treatment or NQO1 siRNA knockdown inhibited this sulindac-induced increase in β-lapachone cytotoxicity. In conclusion, sulindac and its metabolites synergistically increase the anticancer effects of β-lapachone primarily by increasing NQO1 activity and expression, and these two drugs may provide a novel combination therapy for lung cancers.

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“…El adenocarcinoma es el tipo más común de cáncer pulmonar, ocurre en 30 a 35% de los casos (8) . Los lugares frecuentes de metástasis son hígado, hueso, cerebro, ganglios y glándulas suprarrenales (6,9,10) . La metástasis pericárdica no es una manifestación frecuente, pero cuando el pericardio es infiltrado por una neoplasia maligna, esta procede principalmente de una neoplasia pulmonar (11) .…”

Section: Introductionunclassified

“…La sintomatología depende mas del tipo histológico, que de la localización de la metástasis, cuando el pericardio esta comprometido puede ser pericarditis con derrame y taponamiento pericárdico, en los casos que el derrame se ha producido de manera rápida (8,13) . Las manifestaciones paraneoplásicas dependen de la secreción de péptidos hormonales o sus precursores, de citoquinas y, más raramente, de hormonas tiroideas y otras, que actúan de forma endocrina, paracrina o autocrina (6,9,10) . En ocasiones, los síndromes paraneoplásicos pueden ser más graves que las consecuencias del propio tumor primario y pueden preceder, ir en paralelo o seguir a las manifestaciones clínicas de dicho tumor (14) .…”

Section: Introductionunclassified

Síndrome de Doege Potter y derrame pericárdico, como manifestaciones iniciales de neoplasia pulmonar

2013

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Síndrome de Doege Potter y derrame pericárdico, como manifestaciones iniciales de neoplasia pulmonarResumen Comunicamos el caso de un paciente de 52 años que ingresa a nuestro hospital por presentar derrame pericárdico masivo y manifestaciones de hipoglicemia de manera repetitiva, sin antecedentes de tabaquismo, diabetes mellitus, ni consumo de fármacos. Fue sometido a pericardiocentesis, obteniéndose 1 430 mL de líquido de aspecto serosanguinolento, el mismo que se remitió para estudio, demostrándose un exudado polimorfonuclear, adenosina deaminasa (ADA) positivo y presencia de células compatibles con adenocarcinoma metastático. Se observó en la radiografía de tórax y tomografía axial computarizada pulmonar la presencia de una masa en la región parahiliar izquierda compatible con una neoplasia maligna, con derrame pleural y pericárdico. Se trató de una presentación poco frecuente de neoplasia maligna pulmonar, con metástasis pericárdica, derrame pleural izquierdo y un síndrome paraneoplásico endocrino, caracterizado por hipoglicemia a repetición, como manifestación inicial. Palabras clave: Enfermedades pulmonares; neoplasias; metástasis de la neoplasia; derrame pleural; síndromes paraneoplásicos endocrinos. AbstractA 52 year-old man was admitted to our hospital because of large pericardial effusion and symptoms of recurrent hypoglycaemia. He had no history of smoking or diabetes mellitus and was taking no medication. Diagnostic pericardiocentesis was performed and 1 430 mL of bloody-stained fluid was obtained. The exudate showed neutrophils positive to adenosin deaminase (ADA) test. Chest X-ray and computed tomography showed a left lung hilar mass resembling a lung neoplasm, with pleural and pericardial effusion. It was a lung cancer of unusual presentation, with pleural and pericardial metastasis and a paraneoplastic syndrome characterized by recurrent hypoglycaemia as initial manifestation.

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Metastatic Non-Small Cell Lung Cancer in Brazil: Treatment Heterogeneity in Routine Clinical Practice

Cited by 18 publications

References 17 publications

Surgical Resection of Lung Metastases: Results from 529 Patients

Surgical Resection of Lung Metastases: Results from 529 Patients

Sulindac Compounds Facilitate the Cytotoxicity of β-Lapachone by Up-Regulation of NAD(P)H Quinone Oxidoreductase in Human Lung Cancer Cells

Síndrome de Doege Potter y derrame pericárdico, como manifestaciones iniciales de neoplasia pulmonar

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