Metastatic neoplasms of the vertebral column producing compression of the spinal cord

Kennady, J. C.; Stern, Walter H.

doi:10.1016/0002-9610(62)90316-1

Cited by 32 publications

(5 citation statements)

References 19 publications

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“…The acuity of onset and the rapidity of progression to complete or incomplete paraplegia was notable in this series, and this was described in previous reports (Arseni, Simionescu and Horwath, 1959;Barron et al, 1959;Kennady and Stern, 1962;Torma, 1957). This rapid progression has been considered to be due to tumour growth and a high incidence of pathological vertebral fractures.…”

Section: Discussionsupporting

confidence: 86%

“…The clinical findings are consistent in this series with previous reports of spinal cord compression and paraplegia due to vertebral metastases (Alexander et ai., 1956;Bansal et ai., 1967;Botterell and Fitzgerald, 1959;Brice and McKissock, 1965;Dickson, 1968 ;Kennady and Stern, 1962;Mullan and Evans, 1957;Perese, 1958;Smith, 1965;Torma, 1957;Wild and Porter, 1963).…”

Section: Discussionmentioning

confidence: 99%

“…The commonest presenting symptom was pain, usually in the back. Kennady and Stern (1962) stated that a characteristic spinal symptom was pain in almost all of the 103 cases which they studied. Spinal cord or nerve root compression may also be the presenting feature of the primary tumour, as was the case in four of our patients.…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports on this subject generally emphasise the clinical aspects (Alexander, Davis and Field, 1956;Botterell and Fitzgerald, 1959;Kennady and Stern, 1962;Mullan and Evans, 1957;Torma, 1957). Few give detailed descriptions of the metastatic deposits within the spinal column or of the spinal cord neuropathology (McAlhany and Netsky, 1955).…”

Section: Introductionmentioning

confidence: 99%

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Vertebral metastases and spinal cord compression

et al. 1983

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Summary. Clinical interest in spinal compression and resultant paraplegia due to metastases has mounted in recent years. This has stimulated attention to the neuropathology of the condition. Fourteen cases of spinal cord compression due to vertebral metastases are compared with over 100 traumatic cases. In the traumatic lesions there is central haemorrhagic necrosis leading to cavitation and gliosis with nerve root regeneration in the late stages. In the metastatic cases, lesions are often peripheral, pie-shaped and are related to vascular factors. The neuro pathology of cord necrosis due to metastatic spinal disease is therefore different to trauma. These observations have clinical importance in planning treatment.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vertebral metastases and spinal cord compression

et al. 1983

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“…3,4,7 After treatment, 67% to 100% of the patients with SEM who are ambulant at presentation can still walk; 30% to 40% of patients with paraparesis may regain ambulation with adequate treatment compared with only 10% or fewer patients with paraplegia. 3,4,7 Unfortunately, even in more recent studies, [8][9][10][11][12][13][14][15][16] more than 20% of the patients are unable to walk at the time of diagnosis.…”

mentioning

confidence: 99%

Prediction of Spinal Epidural Metastases

Kienstra¹,

Terwee²,

Dekker³

et al. 2000

Arch Neurol

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Neurologic Complications of Myelomatosis

Silverstein¹,

Doniger²

1963

Archives of Neurology

130

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have been described previously,1-9 there still remains some controversy concerning the incidence, pathogenesis, and treatment of the several types of neurologic complications of the disease. Many of the previous publications of the neurologic aspects of myelomatosis were based on observations of small series of patients who were sometimes specially selected (eg, those admitted to a neurosurgical service). The emphasis of many of the previous reports has been either on the direct compression of the nervous system by myeloma tumor or on distant "toxic" effects. In the older literature, the criteria for the diagnosis of multiple myeloma have, at times, also been uncertain.The purpose of this communication is to report and discuss the neurologic complications observed in 277 patients admitted to a general hospital, where a diagnosis of multiple myeloma was eventually proved. Materials and MethodsThe 277 patients were all studied at The Mount Sinai Hospital, New York. The clinical and labora¬ tory features of some 90 of these patients were collected in a monograph ten years ago.8 A few others have also been previously reported.8"11 For inclusion in this series all patients satisfied at least two of the following criteria for the diagnosis of myelomatosis: (1) histologie (biopsy or autopsy) proof of the disease; (2) bone marrow obtained by aspiration, showing more than 15% plasma cells ;(3) a homogeneous protein spike in serum or urine electrophoresis ; (4) Bence Jones proteinuria ; and (5) characteristic abnormalities on roentgenograms of the skull and other bones. The last three criteria were accepted only if another disease (eg, macroglobulinemia, leukemia, metastatic carcinoma) was excluded. Seven patients with a solitary plasmacytoma have been included, although not all could be followed until their disease became generalized.The neurologic data were obtained by reviewing clinical records, autopsy protocols, operative notes, myelograms, and other available studies. For con-

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Metastatic neoplasms of the vertebral column producing compression of the spinal cord

Cited by 32 publications

References 19 publications

Vertebral metastases and spinal cord compression

Vertebral metastases and spinal cord compression

Prediction of Spinal Epidural Metastases

Neurologic Complications of Myelomatosis

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