Metastatic neoplasms of the ovaries: a clinicopathological study of 97 cases

Kondi-Pafiti, Agathi; Kairi-Vasilatou, E; Iavazzo, Christos; Dastamani, Christina; Bakalianou, K; Liapis, Angelos; Hassiakos, Dimitrios; Fotiou, Stelios

doi:10.1007/s00404-011-1847-4

Cited by 43 publications

(47 citation statements)

References 19 publications

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“…CIMP has been examined to a limited extent in ovarian carcinoma. The interpretation of data concerning ovarian MC is further complicated by the fact that a considerable part of MC consists of metastases from primary tumours originating elsewhere in the body, mainly from the gastrointestinal tract [128][129][130][131]. Because differentiation between a primary MC and metastasis is difficult, it is possible that a proportion of carcinomas that are considered ovarian MC are in fact metastatic CRC.…”

Section: Mucinous Ovarian Carcinomamentioning

confidence: 99%

The molecular background of mucinous carcinoma beyond MUC2

Hugen

Simons²,

Halilović³

et al. 2014

Clin J Pathol

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The increasing interest of the oncology community in tumour classification and prediction of outcome to targeted therapies has put emphasis on an improved identification of tumour types. Colorectal mucinous adenocarcinoma (MC) is a subtype that is characterized by the presence of abundant extracellular mucin that comprises at least 50% of the tumour volume and is found in 10-15% of colorectal cancer patients. MC development is poorly understood, however, the distinct clinical and pathological presentation of MC suggests a deviant development and molecular background. In this review we identify common molecular and genetic alterations in colorectal MC. MC is characterized by a high rate of MUC2 expression. Mutation rates in the therapeutically important RAS/RAF/MAPK and PI3K/AKT pathways are significantly higher in MC compared with non-mucinous adenocarcinoma. Furthermore, mucinous adenocarcinoma shows higher rates of microsatellite instability and is more frequently of the CpG island methylator phenotype. Although the majority of MCs arise from the large intestine, this subtype also develops in other organs, such as the stomach, pancreas, biliary tract, ovary, breast and lung. We compared findings from colorectal MC with tumour characteristics of MCs from other organs. In these organs, MCs show different mutation rates in the RAS/RAF/MAPK and PI3K/ AKT pathways as well, but a common mucinous pathway cannot be identified. Identification of conditions and molecular aberrations that are associated with MC generates insight into the aetiology of this subtype and improves understanding of resistance to therapies.

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Section: Mucinous Ovarian Carcinomamentioning

confidence: 99%

The molecular background of mucinous carcinoma beyond MUC2

Hugen

Simons²,

Halilović³

et al. 2014

Clin J Pathol

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“…Kondi-Pafiti A et al 16 did a clinicopathological study of 97 cases of metastatic neoplasms of the ovary and found 62.89% of the tumors were metastasized from extragenital organs and 37.11% tumors originated from the genital tract. We found a case of metastasis of squamous cell carcinoma in ovary in 35 year old female in a known case of squamous cell carcinoma of cervix.…”

Section: Discussionmentioning

confidence: 99%

A Clinico-Pathological Study of 120 Cases of Ovarian Tumors in a Tertiary Care Hospital

A¹,

A²,

S³

2018

IJCMR

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“…Bu dönemde metastatik over tümör-leri, over kanlanmasının fazla olmasına bağlı ola- rak daha sık izlenmektedir. 5 Çalışmamızın en önemli sonuçlarından biri, reprodüktif dönem malign adneksiyal kitlelerin ayırıcı tanısında metastatik over tümörlerinin önemli bir yer tutmasıdır. Adneksiyal kitleler; semptomatik bir hastanın fizik muayene ve görüntüleme yöntemleri esnasında, rutin jinekolojik kontroller sırasında ve farklı endikasyonlarla istenen görüntülemelerde tesadü-fen olmak üzere başlıca üç yolla prezante olmaktadır.…”

Section: Discussionunclassified

Adnexal Masses: Retrospective Assessment of 424 Cases and Review of the Literature

Kurt¹,

Canda²,

Kopuz³

et al. 2016

Turkiye Klinikleri J Gynecol Obst

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A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Ovaryum ve tuba uterina hastalıkları; over tümörleri; CA-125 antijeni; tümör metastazı; patoloji A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To review the pathological diagnosis of patients underwent laparotomy for adnexal masses accompanied by the literature. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The results of 424 patients from a single center were evaluated. Research criteria include the patient to be of reproductive age or postmenopausal age, CA-125 levels, ascites, bilaterality and whether the pathologic diagnosis of the mass is benign or malignant. R Re es su ul lt ts s: : 200 (47.17%) patients were in the reproductive period, 224 (52.83%) patients were in the postmenopausal period, the average age of the population was 52.65±1.04. Adnexal masses originated from; ovary 385 (90.8%), tuba 22 (5.18%), uterus 3 (0.7%) and distant organs 14 (3.3%). While 18.51% of patients pathologically diagnosed as benign were bilateral, 56.89% of malign patients were bilateral. The presence of the acid was observed in 4.2% of benign patients and in 37.06% of the malign patients. The malignancy was diagnosed in 48 (24%) patients in the reproductive period and 68 (30.35%) patients in the postmenopausal period for laparotomies performed for adnexal masses. The most common benign pathologies in the reproductive period was serous cystadenoma, endometrioma and mucinous cystadenoma, while in the postmenopausal period was serous cystadenoma, mucinous cystadenoma and mature teratoma. The most common malignant pathologic diagnosis in the reproductive period was serous adenocarcinoma, metastatic cancers and endometrioid adenocarcinoma, while in the postmenopausal period was serous adenocarcinoma, mucinous carcinoma and endometrioid adenocarcinoma. Metastatic cancers are more frequent during the reproductive years, the most common benign pathology in both groups was ovarian serous cystadenomas, and malignant pathology in both groups was ovarian serous cystadenocarcinoma. 21 malignant cases (43.75%) in the reproductive period has a CA-125 value higher than 200 mU / ml, while 60 malignant cases (88.20%) in the postmenopausal period has a CA-125 value higher than 35 mU / ml. C Co on nc cl lu us si io on n: : Ovarian pathologies constitute the majority of the adnexal masses. The probability of malignancy increases with advancing age, bilaterality, presence of ascites and high CA-125 values. The frequency of metastatic ovarian cancers in the reproductive period is the characteristic of series.

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Metastatic neoplasms of the ovaries: a clinicopathological study of 97 cases

Abstract: The management of metastatic ovarian neoplasms should include specific immunohistochemical methods in order to identify the primary neoplasm site. The differential diagnosis of a pelvic mass should always include metastatic neoplasms of the ovaries.

Cited by 43 publications

References 19 publications

The molecular background of mucinous carcinoma beyond MUC2

The molecular background of mucinous carcinoma beyond MUC2

A Clinico-Pathological Study of 120 Cases of Ovarian Tumors in a Tertiary Care Hospital

Adnexal Masses: Retrospective Assessment of 424 Cases and Review of the Literature

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