Metastatic mixed acinar‐neuroendocrine carcinoma of the pancreas treated by a multidisciplinary team: A case report and brief review of the literature

Tang, Xiu Jun; Fang, Xue Feng; Zhu, Lei; Wei, Qi; Bai, Xue; Liang, Ting; Yuan, Ying

doi:10.1111/1751-2980.12752

Cited by 5 publications

(6 citation statements)

References 26 publications

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“…Acinar cell carcinoma and neuroendocrine carcinoma are rare types among pancreatic neoplasms. [ 9 ] To differentiate between MANEC and acinar cell carcinoma, more than 30% of the tumor must comprise neuroendocrine cells. [ 10 ] However, very few cases of MANECs have histologically distinct acinar and neuroendocrine areas, with most cases representing a uniform cell population.…”

Section: Discussionmentioning

confidence: 99%

Malignant pancreatic tumor other than solid pseudopapillary tumor in pediatric patients

2021

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Pancreatic tumors, except solid pseudopapillary tumors (SPTs), are rare in pediatric patients. Herein, we report various types of pancreatic tumors in pediatric patients and review the literature regarding their treatments and prognosis. We retrospectively reviewed the data of pediatric patients who underwent surgery for pancreatic tumors, excluding SPTs, between January 2009 and December 2019 at Seoul National University Children's Hospital. A total of 35 pediatric patients were identified as having undergone surgery for pancreatic tumors. Of these patients, 30 were excluded because the tumor was identified as an SPT. The diagnoses of the five remaining (non-SPT) pancreatic tumors were pancreatic neuroendocrine tumor, mixed acinar neuroendocrine carcinoma, kaposiform hemangioendothelioma, and intraductal papillary mucinous neoplasm. All five patients survived; however, recurrence and liver metastasis were observed in one patient. The detailed demographics, treatments, and prognosis of each patient were reviewed. Despite the rarity and low i ncidence of pancreatic tumors in pediatric patients, four types of non-SPT tumors are reported here. Hence, the possibility of these should not be overlooked, especially since the diagnosis and adjuvant treatment differ vastly between the tumor types.

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Section: Discussionmentioning

confidence: 99%

Malignant pancreatic tumor other than solid pseudopapillary tumor in pediatric patients

2021

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“…Imaging often shows single mass in the pancreas which is either ill-defined [32] or well circumscribed [29]; solid [1], cystic [26], hemorrhagic [4], hypervascular [6,10,17] or necrotic mass often with metastases, especially of the liver [8,9,20] and ampulla of vater [25].…”

Section: Discussionmentioning

confidence: 99%

Mixed Acinar- Neuroendocrine Carcinoma of the Pancreas: A Rare Case Report with Comprehensive Review of Literature

Arshi¹,

Rao²

2021

JJGH

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“…Mixed acinar–neuroendocrine carcinomas are rare and account for nearly one-fifth of all pancreatic ACCs[ 49 , 94 ]. The features of these tumors do not differ from the macroscopic features of ACC, and the tumors are quite large.…”

Section: Organ-specific Clinicopathological Findingsmentioning

confidence: 99%

“…In the differential diagnosis, morphological and IHC findings should be evaluated together, such as in ductal carcinoma. It is worth noting that 20%-30% of ACCs show a small neuroendocrine cell population, and this morphologically undetected component should not lead to the diagnosis of MiNEN[ 49 ]. Immunohistochemical staining with trypsin and bcl-10 [monoclonal antibody directed against the C-terminal portion of bcl-10 (clone 331.3)] is very useful for identifying the acinar component[ 102 ] (Figure 3 ).…”

Section: Organ-specific Clinicopathological Findingsmentioning

confidence: 99%

“…A recent study suggested that c-MYC alterations are involved in mechanisms leading to the neuroendocrine differentiation of ACCs[ 46 ]. Surgical resection and tumor stage are the most important prognostic factors, and the reported 5-year survival rate is 30%–50% for patients who undergo surgery[ 49 , 105 ].…”

Section: Organ-specific Clinicopathological Findingsmentioning

confidence: 99%

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Mixed neuroendocrine–nonneuroendocrine neoplasms of the gastrointestinal system: An update

Elpek¹

2022

WJG

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Mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) of the digestive tract are a rare heterogeneous group of tumors that present many challenges in terms of diagnosis and treatment. Over the years, the diagnostic criteria, classification, and clinical behavior of these tumors have been the subjects of ongoing debate, and the various changes in their nomenclature have strengthened the challenges associated with MiNENs. This review is performed to provide an understanding of the key factors involved in the evolution of the designation of these tumors as MiNEN, highlight the current diagnostic criteria, summarize the latest data on pathogenesis and provide information on available treatments. Moreover, this work seeks to increase the awareness about these rare neoplasms by presenting the clinicopathological features and prognostic factors that play important roles in their behavior and discussing their different regions of origin in the gastrointestinal system (GIS). Currently, the MiNEN category also includes tumors in the GIS with a nonneuroendocrine component and epithelial tumors other than adenocarcinoma, depending on the organ of origin. Diagnosis is based on the presence of both morphological components in more than 30% of the tumor. However, this value needs to be reconfirmed with further studies and may be a limiting factor in the diagnosis of MiNEN by biopsy. Furthermore, available clinicopathological data suggest that the inclusion of amphicrine tumors in the definition of MiNEN is not supportive and warrants further investigation. The diagnosis of these tumors is not solely based on immunohistochemical findings. They are not hybrid tumors and both components can act independently; thus, careful grading of each component separately is required. In addition to parameters such as the metastatic state of the tumor at the time of diagnosis and the feasibility of surgical resection, the aggressive potential of both components has paramount importance in the choice of treatment. Regardless of the organ of origin within the GIS, almost MiNENs are tumors with poor prognosis and are frequently encountered in the elderly and men. They are most frequently reported in the colorectum, where data from molecular studies indicate a monoclonal origin; however, further studies are required to provide additional support for this origin.

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Metastatic mixed acinar‐neuroendocrine carcinoma of the pancreas treated by a multidisciplinary team: A case report and brief review of the literature

Cited by 5 publications

References 26 publications

Malignant pancreatic tumor other than solid pseudopapillary tumor in pediatric patients

Malignant pancreatic tumor other than solid pseudopapillary tumor in pediatric patients

Mixed Acinar- Neuroendocrine Carcinoma of the Pancreas: A Rare Case Report with Comprehensive Review of Literature

Mixed neuroendocrine–nonneuroendocrine neoplasms of the gastrointestinal system: An update

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