Metastatic melanoma to the common bile duct causing obstructive jaundice: A case report

Colović, R; Grubor, Nikica; Jovanovic, Miodrag D; Micev, Marjan; Čolović, Nataša

doi:10.3748/wjg.v13.i5.813

Cited by 17 publications

(8 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 7 ] Ultrasonic features may help to diagnose melanoma metastases preoperatively. Metastatic melanoma of the common bile duct (CBD) is very rare, with only 18 cases reported so far;[ 8 ] the most common presentation in these cases is of progressive painless obstructive jaundice with few rare cases presenting with hematobilia,[ 9 ] pain,[ 10 ] or cholangitis. [ 11 ] Laboratory investigations in these cases suggest cholestatic jaundice.…”

Section: Discussionmentioning

confidence: 99%

Choroidal melanoma metastatizing to the biliary system: A diagnostic dilemma

Agarwal

Bhattacharya

Patil

et al. 2009

Indian J Med Paediatr Oncol

View full text Add to dashboard Cite

Metastatic melanoma to the gall bladder is extremely rare and is associated with a very poor prognosis. We report a case of choroidal melanoma metastatizing to the hepatobiliary system, with an unusual presentation. Our patient presenting with obstructive jaundice was misdiagnosed as having carcinoma of the gall-bladder, but the diagnosis of metastatic melanoma to the gallbladder was confirmed by ultrasonography guided fine needle aspiration cytology (USG-FNAC). On reviewing the past history, the patient had a history of enucleation for choroidal melanoma. Even though the liver ‘is’ a common site for metastasis of choroid melanoma, the patient presenting with a suspected gall bladder mass ‘is’ a rare presentation. Hence, gastrointestinal symptoms and a history of melanoma should be investigated for the presence of gastrointestinal or liver metastases, even if the original primary malignancy was diagnosed years before the patient‘s presentation.

show abstract

Section: Discussionmentioning

confidence: 99%

Choroidal melanoma metastatizing to the biliary system: A diagnostic dilemma

Agarwal

Bhattacharya

Patil

et al. 2009

Indian J Med Paediatr Oncol

View full text Add to dashboard Cite

show abstract

“…Metastasis-induced common bile duct stenosis can be demonstrated by the use of endoscopic retrograde cholangiopancreatography, showing filiform stenosis in one reported patient (Brankamp et al 2007) and a complex filling defect in another (Garas et al 2000). The lesions are also demonstrated by intraoperative cholangiography (Colovic et al 2007). Expectedly, also melanoma metastatic to the ampulla may cause massive stenosis and obstructive jaundice (Sans et al 1996;Caballero-Mendoza et al 1999).…”

Section: Malignant Melanoma Metastatic To the Bile Ductsmentioning

confidence: 97%

“…An autopsy study demonstrated that patients with metastasizing melanoma had biliary duct metastases in 6 %, in contrast to 15 % with metastases to the gallbladder (Das Gupta and Brasfield 1964). The metastatic sites involve the common bile duct (Armbruster 1973;Cole and Freston 1973;Bowdler and Leach 1982;Daunt and King 1982;McArthur and Teergarden 1983;O'Connell et al 1984;Kohler and Riemann 1987;Cohen et al 1990;England and Sarr 1990;Parquier et al 1991;Thompson et al 1993;Garas et al 2000;Grasso et al 2003;Uchikov et al 2004;Cardot-Leccia et al 2005;Van Bokhoven et al 2006;Colovic et al 2007;Rezanko et al 2008), the cystic duct (O'Connell et al, 1984), and the ampullary region (Sans et al 1996;Van Bokhoven et al 2006). Metastasis to the common bile duct may cause obstructive jaundice with marked cholestasis, sometimes combined with hemobilia (Cole and Freston 1973;McArthur and Teergarden 1983;Kohler and Riemann 1987;England and Sarr 1990;Parquier et al 1991;Thompson et al 1993;Brankamp et al 2007).…”

Section: Malignant Melanoma Metastatic To the Bile Ductsmentioning

confidence: 99%

Primary and Secondary Malignant Melanoma, and Other Melanotic Tumor, of the Hepatobiliary Tract

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

View full text Add to dashboard Cite

Malignant melanoma (MM) is an aggressive malignancy that frequently involves the hepatobiliary tract, due to the frequent metastases to the liver. Therefore, most of malignant melanotic lesions detected in the liver and bile ducts are metastases of skin melanomas. But there is a small group of MM that takes its origin in the hepatobiliary tract, albeit the cell of origin is not yet known, possibly a neural crest cell that homed to this organ during embryogenesis. Primary MM is well documented for extrahepatic bile ducts and the gallbladder, where primary MMs have been described since long. In particular, primary gallbladder MM is a recognized entity with characteristic growth patterns. In contrast, primary hepatic MM is less well defined and numerous cases published in the old literature may be misinterpretations because metastatic disease is difficult to exclude in many cases, because the primary tumor may have been missed or had regressed. A distinct situation is ocular MM which is known to produce liver metastases after a long time delay. There are rare other melanotic tumors that can manifest in the liver, including melanotic progonoma. A tumor related to MM and known to have visceral manifestations is clear cell sarcoma or melanoma of soft parts.

show abstract

“…The American Cancer Society has estimated almost 60 000 new cases of melanoma and over 8000 deaths because of melanoma for 2007. Unlike many types of cancers, which have preferred regions of metastasis, cutaneous melanoma has been observed to metastasize to virtually every tissue, including the gastrointestinal tract, gall bladder, and heart [1][2][3]. Not infrequently, a patient may initially present with a visceral mass that on pathologic evaluation is found to be metastatic melanoma without a known cutaneous primary site.…”

Section: Introductionmentioning

confidence: 99%

Melanoma presenting as circulating tumor cells associated with failed angiogenesis

Lee¹,

Fallarino²,

Ashikari³

et al. 2008

Melanoma Research

View full text Add to dashboard Cite

The ability of cancer cells to promote angiogenesis has been associated with a transition from a micrometastatic phenotype to a state in which large solid metastases can form. We describe a case of metastatic melanoma that presented with large numbers of circulating tumor cells and tissue infiltration without large solid metastases. Immunohistochemistry and reverse transcriptase-PCR was used to study the expression of melanoma tumor markers in circulating tumor cells. A tumor cell line was established from the patient and analyzed for adhesion molecule expression, expression of vascular endothelial growth factor, and the ability to inhibit solid tumor formation by other melanoma cells implanted as a xenograft. Examination of the circulating tumor cells confirmed they were of melanoma origin. Analysis of the tumor cell line obtained from this patient demonstrated intact expression of alpha and beta integrins but poor production of vascular endothelial growth factor, and also the ability to inhibit solid tumor formation of third-party melanoma tumors, suggesting a strong antiangiogenic activity. Our results indicate that lethal metastatic melanoma can occur even if tumor angiogenesis is defective, an observation that has implications for potential limits of antiangiogenic therapies.

show abstract

Metastatic melanoma to the common bile duct causing obstructive jaundice: A case report

Cited by 17 publications

References 13 publications

Choroidal melanoma metastatizing to the biliary system: A diagnostic dilemma

Choroidal melanoma metastatizing to the biliary system: A diagnostic dilemma

Primary and Secondary Malignant Melanoma, and Other Melanotic Tumor, of the Hepatobiliary Tract

Melanoma presenting as circulating tumor cells associated with failed angiogenesis

Contact Info

Product

Resources

About