Metastatic Melanoma of the Stomach

Santos-Seoane, S.M.; Pérez-Casado, Lucía; Helguera-Amezua, Cristina; Diez-Fernández, Miriam

doi:10.1016/j.cireng.2018.11.018

Cited by 4 publications

(1 citation statement)

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“…Stomach is a rare site for metastasis and accounts for an average of 27% of the cases with GI tract metastatic melanoma. The postoperative mortality is almost 5%, and the median survival of patients is 4 to 6 months, with 1-and 5-year survival rates of 44% and 9%, respectively (5). The endoscopic biopsy is a helpful method (but not accurate) for diagnosis (6, 7).…”

Section: Introductionmentioning

confidence: 99%

Metastatic Malignant Melanoma of the Stomach: An Unexpected Phenomenon of the Disease

Nematollahi¹

2023

J Clin Stud Med Case Rep

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Section: Introductionmentioning

confidence: 99%

Metastatic Malignant Melanoma of the Stomach: An Unexpected Phenomenon of the Disease

Nematollahi¹

2023

J Clin Stud Med Case Rep

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Metastatic Malignant Melanoma of the Stomach: An Unexpected Phenomenon of the Disease

Hosseini

Rouhi

Nematollahi

et al. 2023

Preprint

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Background Gastrointestinal (GI) melanomas are uncommon, and the stomach is a rare site for metastasis and accounts for 27% of the cases with GI tract metastatic melanoma. Clinical manifestations are usually nonspecific, and many patients are asymptomatic until the disease progresses further, but may be presented with nausea, vomiting, weight loss, abdominal pain, hematemesis, melena, and iron deficiency. The prognosis is very poor, and the median survival of the patient is 4 to 6 months. The diagnosis is confirmed with postoperative pathological examination and immunohistochemical study. Treatment options include surgical resection, immunotherapy, and targeted therapy. Case Presentation: The presented case is a 71-year-old male, previously diagnosed with cutaneous melanoma of the left retroauricular region, that presented with upper GI tract symptoms and cervical lymphadenopathies about one year after the diagnosis of the primary tumor. An upper GI endoscopy was done, and a pathological examination of the biopsy specimen confirmed the metastatic melanoma of the stomach. Conclusion Regarding the unfavorable outcome of gastric metastatic melanoma, the treatment choice is still under investigation. However, early diagnosis is important for the appropriate assessment of patients as candidates for surgical interventions.

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Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review

Liu¹,

Pan

Gao

2023

Oncol Lett

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Primary malignant melanoma (MM) of the external ear accounts for a low proportion of cases of cutaneous MM, and its incidence in non-white women is very low. The stomach is a rare metastatic site for MM. Gastric metastasis of MM of the external ear is extremely rare, and the associated gene alterations and mechanisms are poorly understood. The present report describes the case of a 58-year-old Asian woman who had a mass on the left auricle for 5 years and was diagnosed with nodular MM with the BRAF V600E mutation after surgical resection. Postoperative metastases to the stomach and descending duodenum appeared 1 year after resection. After 11 months of BRAF-targeted therapy and immunotherapy, the patient developed drug resistance and died from systemic metastases to the brain, lungs, liver, left adrenal gland and peritoneum. Genetic testing revealed additional aberrations in MYB, p16, MYC and PTEN. The clinical characteristics of MM of the external ear and gastric metastatic MM were also summarized through a retrospective literature review. Immunohistochemical staining is critical in the diagnosis of gastric metastasis from MM of the external ear. This disease often requires a multidisciplinary treatment approach, including surgery, targeted therapy and immunotherapy. The present study provides some genetic information about this rare disease and discusses appropriate treatment strategies. The findings of the present study suggests that the surgical margin size, tumor histological type and number of genetic aberrations may be closely associated with metastasis potential, therapeutic efficacy and patient outcome.

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Metastatic Melanoma of the Stomach

Cited by 4 publications

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Metastatic Malignant Melanoma of the Stomach: An Unexpected Phenomenon of the Disease

Metastatic Malignant Melanoma of the Stomach: An Unexpected Phenomenon of the Disease

Metastatic Malignant Melanoma of the Stomach: An Unexpected Phenomenon of the Disease

Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review

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