Metastatic melanoma.A clinicopathological study

Gupta, Taposh Das; Brasfield, Richard D.

doi:10.1002/1097-0142(196410)17:10<1323::aid-cncr2820171015>3.0.co;2-n

Cited by 415 publications

(182 citation statements)

References 15 publications

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“…On examination, he was febrile and there was tenderness upon palpation of the right upper abdominal quadrant and the epigastrium. Laboratory tests were within normal limits (white blood cell count 10 600/mm 3 , normal liver enzymes and normal serum amylase). an ultrasound scan demonstrated sludge in the gallbladder and thickening of the gallbladder wall, without dilatation of the intra and extrahepatic biliary tree.…”

Section: Case Reportmentioning

confidence: 94%

“…Metastases of the biliary tract are rare. Autopsy studies have shown that gallbladder metastases are found in 15% of patients with metastatic melanoma of the gastrointestinal tract, but are reported rarely during the lifetime of the patient because involvement of the gallbladder seldom produces symptoms [3] . We report a case of metastatic melanoma of the gallbladder in a patient who developed symptomatic acute cholecystitis.…”

Section: Introductionmentioning

confidence: 99%

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Metastatic melanoma of the gallbladder: An unusual clinical presentation of acute cholecystitis

Vernadakis¹,

Rallis²,

Danias³

et al. 2009

WJG

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Metastatic disease from cutaneous melanoma can affect all organs of the body, and varies in its biological behavior and clinical presentation. We present the case of a 58-year-old man who arrived at our clinic with acute abdominal pain, which, after investigation, was diagnosed as acute cholecystitis. The patient underwent laparotomy and cholecystectomy. Two years ago, he underwent surgical removal of a primary cutaneous melanoma on his right upper back. Pathological examination revealed the presence of malignant melanoma with a metastatic lesion of the gallbladder.

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Section: Case Reportmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Metastatic melanoma of the gallbladder: An unusual clinical presentation of acute cholecystitis

Vernadakis¹,

Rallis²,

Danias³

et al. 2009

WJG

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“…Têm-se encontrado metastases em locais raros, como miocárdio e endocárdio. Certos locais são sítios mais freqüentes de metastases, como por exemplo linfonodos, pulmão, fígado, a própria pele (subcutâneo e região intradérmica) e ossos 19,20 .0 nevo melanócitico gigante tem grande capacidade de desenvolver melanoma" ,, 22 • 23 • 2l, e, quando este está presente, a incidência estimada de metástase no sistema nervoso central (SNC) é em torno de 40% 7,11,13,32 .…”

Section: Discussionunclassified

Líquido cefalorraquiano no diagnóstico de metástase cérebro-meníngea de melanoma maligno derivado de nevo melanocítico gigante congênito: relato de caso

Rolim

Barsottini

Prado

et al. 1996

Arq. Neuro-Psiquiatr.

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RESUMO -Relatamos o caso de um paciente, de 28 anos, portador de nevo melanocítico gigante congênito(NMGC), com transformação em melanoma e metastátase no sistema nervoso central (SNC). Descrevemos resumidamente as características patológicas de ambas as lesões(NMGC e melanoma), a frequência de malignização do NMGC, os órgãos mais frequentemente acometidos pelas metastases do melanoma -dando ênfase ao acometimento do SNC -além dos fatores que podem levar à malignização do NMGC, os exames usados para o diagnóstico das metástases no SNC -ressaltando a importância do líquido cefalorraquiano -e algumas modalidades terapêuticas para o melanoma com acometimento do SNC.PALAVRAS-CHAVE: Melanoma maligno, metástase, sistema nervoso central, líquido cefalorraquidiano, nevo melanocítico gigante congênito.Cerebral spinal fluid to diagnose CNS metastasis from malignant melanoma arising in a giant congenital melanocytic nevus: case report ABSTRACT -We describe the case of a 28-year-old man with a giant congenital melanocytic nevus (GCMN) with malignant transformation to melanoma and metastasis on the central nervous system (CNS). We also make a summary of the pathological features from both lesions(GCMN and melanoma), the occurrence of malignancy of GCMN, the organs more frequently involved with metastatic melanoma -with emphasis to involvement of CNSjust as the factors that cause malignant transformation of GCMN; the methods to diagnose metastases in CNS -emphasizing the importance of cerebrospinal fluid -and some therapeutical modalities for the metastatic melanoma in CNS.KEY WORDS: Melanoma, metastases, central nervous system, cerebrospinal fluid, giant congenital melanocytic nevus.O nevo melanocítico gigante congênito (NMGC) ocorre aproximadamente em 1 entre 20000 nascidos vivos. Seu potencial de transformação maligna é variável, havendo dados na literatura variando de 2% a 419b 23 .0 melanoma maligno é diagnosticado com freqüência na Europa e América do Norte. Na Grã-Bretanha já é agora mais comum que a doença de Hodgkin 6 . O melanoma é a terceira causa mais freqüente de metastases cerebrais depois do carcinoma de mama e pulmão 23 . O nevo pigmentar ou melanocítico é dividido histologicamente em nevo de junção, intra-dérmico e composto, conforme o acúmulo de células melanocíticas ocorra, respectivamente, na junção dermeEstudo realizado no Pronto

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“…Haşim Boyacı, 1 Serap Argun Barış, 1 Tuğba Aşlı Önyılmaz, 1 Kürşat Yıldız, 2 Yusuf Taha Güllü, 1 İlknur Başyiğit, 1 Füsun Yıldız 1 Malignant melanoma is a malignant tumor with increasing prevalence worldwide. However, metastatic malignant melanoma with unknown primary origin is rarely seen.…”

mentioning

confidence: 99%

Lung metastasis of malignant melanoma with unknown primary origin

Boyacı¹,

Barış²,

Önyılmaz³

et al. 2014

Respir Case Rep

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Malignant melanoma is a malignant tumor with increasing prevalence worldwide. However, metastatic malignant melanoma with unknown primary origin is rarely seen. The current study presents a case with bilaterally multiple nodules in pulmonary parenchyma in which no primary malignant site was found, despite detailed screening and diagnosed as metastasis of malignant melanoma by surgical lung biopsy. The current case is presented as a reminder that malignant melanoma should be kept in mind in metastatic lung lesions with unknown primary origin. Key words: Malignant melanoma, unknown primary origin, lung, metastasis, pulmonary nodules.Malign melanom, tüm dünyada prevalansı giderek artan bir malign tümördür. Bununla birlikte, primeri bilinmeyen metastatik malign melanom olguları nadir görülmektedir. Biz de bilateral akciğer parankiminde multipl nodülleri olan ve yapılan tarama tetkiklerinde primer odak saptanamayan ancak açık akciğer biyopsi sonucunda malign melanom metastazı tanısı konulan olgumuzu sunmaktayız. Bu olgu, primeri bilinmeyen akciğer metastazı olgularında malign melanomun da akılda tutulması gerektiğini hatırlat-mak amacıyla sunulmuştur.Anahtar Sözcükler: Malign melanom, primeri bilinmeyen, akciğer, metastaz, pulmoner nodül.

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Metastatic melanoma.A clinicopathological study

Cited by 415 publications

References 15 publications

Metastatic melanoma of the gallbladder: An unusual clinical presentation of acute cholecystitis

Metastatic melanoma of the gallbladder: An unusual clinical presentation of acute cholecystitis

Líquido cefalorraquiano no diagnóstico de metástase cérebro-meníngea de melanoma maligno derivado de nevo melanocítico gigante congênito: relato de caso

Lung metastasis of malignant melanoma with unknown primary origin

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