Metastatic malignant melanoma of the urinary bladder: A case report and review of the literature

Topal, Cumhur Selçuk; Kır, Gözde; Daş, Taner; Sarbay, Billur Cosan; Tosun, Muzaffer İlkay

doi:10.4103/0377-4929.191820

Cited by 6 publications

(5 citation statements)

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“…Metastatic bladder constitutes less than 5% of all bladder tumors and metastatic malignant melanoma to the bladder is very rare with only few cases reported in literature [5]. Clinical evidence of this type of cancer is infrequent and, in most cases, patients presented with hematuria or other urinary tract symptoms.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Melanoma of the Bladder: A Case-Report and Literature Review

Bitton

2019

JUNS

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Melanoma is an aggressive tumour with an increasing incidence. Metastatic melanoma of the bladder is a very rare finding. We report the case of a 78-year-old man who presented with visible hematuria. Cystoscopy revealed bladder lesions that were endoscopically resected and diagnosed as melanoma of the bladder. Past history showed previous skin melanoma eleven years earlier and later recurrence in the left tight in 2016. We will discuss the epidemiology and treatment options of malignant metastatic melanoma based on a review of the literature.

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Section: Discussionmentioning

confidence: 99%

Metastatic Melanoma of the Bladder: A Case-Report and Literature Review

Bitton

2019

JUNS

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“…et al [42] 2011 Primary TURBT and CH some months Efesoy, O. et al [43] 2011 Metastatic TURBT and CHT 7 months Meunier, R. et al [44] 2015 Metastatic TURBT, CH and CHT some months Theocharides, C. et al [45] 2017 Metastatic TURBT and IT some months Paterson, A. et al [46] 2012 Metastatic CH and CHT <5 months Ikeda, A. et al [47] 2013 Metastatic TURBT and CHT <5 months Topal, C.S. et al [48] 2016 Among these, 9 patients had primary/metastatic MM of the kidney and 7 patients primary/metastastic MM of the ureter, 43 patients had primary/metastatic MM of the bladder and 88 patients primary/metastatic MM of the urethra (males and females).…”

Section: Author(s) Year(s) Primary/metastatic Treatment Survivalmentioning

confidence: 99%

“…A few months later, the patient died of metastatic disease progression. Various reports [40][41][42][43][44][45][46][47][48][49][50] have dealt with cases of secondary involvement of the bladder by a previous cutaneous skin melanoma. In one of the most recent of these papers, Topal et al [48] reported their experience of a 70-year-old patient who had presented to the Urology Department for macrohematuria.…”

Section: Urinary Bladdermentioning

confidence: 99%

“…Various reports [40][41][42][43][44][45][46][47][48][49][50] have dealt with cases of secondary involvement of the bladder by a previous cutaneous skin melanoma. In one of the most recent of these papers, Topal et al [48] reported their experience of a 70-year-old patient who had presented to the Urology Department for macrohematuria. Both the TURBT, and the later operative specimen from radical cystectomy, were positive for MM, that appeared to be primary.…”

Section: Urinary Bladdermentioning

confidence: 99%

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Urological Melanoma: A Comprehensive Review of a Rare Subclass of Mucosal Melanoma with Emphasis on Differential Diagnosis and Therapeutic Approaches

Cazzato

Colagrande

Cimmino

et al. 2021

Cancers

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Melanoma is reported as the 19th most common cancer worldwide, with estimated age-standardized incidence rates of 2.8–3.1 per 100,000. Although the origin is most frequently cutaneous, mucosal melanoma has been described several times in literature, and despite its rarity (only 1% of all melanomas), increasing attention is being paid to this disease form. Within this subgroup, melanomas of the uropoetic apparatus are a rarity among rarities. Indeed, less than 50 cases of primary melanoma originating from the urinary bladder have been described, and even less originating from the kidney, renal pelvis and urethra. In this work, we present a detailed review of the literature related to this subclass of mucosal melanoma, delve into the biological landscape of this neoplasm and discuss current approaches, future perspectives and potential therapeutic approaches.

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“…Az irodalomban a melanomaáttétekre vonatkozó közlemények leginkább a szisztémás kezeléssel kapcsolatosak [21]. A húgyhólyagot érintő melanomaáttétről 30 esetben számoltak be a szakirodalomban, 8 hónapos medián túlélés mellett [22]. Melanoma áttétét a húgyvezetékben is észlelték néhány esetben.…”

Section: Eredeti Közleményunclassified

Urogenitalis lokalizációjú mucosamelanoma primer és áttétes esetei klinikánkon

et al. 2019

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Introduction: Both primary and metastatic cases of mucosal melanoma in urogenital localization are rare tumors. Only 4–5% of all primary melanomas do not arise from the skin. Extracutaneous melanomas have a complex clinical presentation, but these aggressive tumors have a poor prognosis. Materials and method: In our department, we found 7 patients with malignant melanoma of the genitourinary tract in the past few years. The 7 cases were: primary amelanotic melanoma of the female urethra, a primary melanoma of the bladder, two primary melanomas of the penis, a metastatic melanoma of the urethra and another to the testis and a metastatic melanoma of the bladder with melanuria. We retrospectively analyzed the available data to describe the presentation, management, and clinical outcome of the patients. Results: In the three inoperative cases, palliative, urologic surgical procedures and systemic antitumor therapy were performed. Two of the four primary urogenital tumors were localized to the penis. In one case, local recurrence developed after surgical treatment, but with a radical, repeated surgery, the patient has been asymptomatic for a year and a half. In the other, neglected case, the penis melanoma spread through the urethra and the inguinal lymph nodes two years after radical surgery and inguinal block dissection. In the female primary urethral melanoma case, the first histological study reported a primary mesenchymal tumor, and the recurrent tumor that occurred one and a half years later showed melanoma diagnosis. Radical surgery performed because of urethral involvement resulted in a 5-year asymptomatic state, followed by local recurrence and distant metastasis. In the fourth case of a primary bladder melanoma, the rapid progression of the disease and the BRAF positivity of the tumor suggested that not the firstly diagnosed bladder melanoma was the primary tumor. Conclusion: The occurrence of urinary tract melanoma is very rare and its discovery happens often in a disseminated state, so the expected prognosis of the cases is also poor. The most important factors for increasing therapeutic efficacy are early diagnosis and radical surgical intervention. Tumors appearing in different localizations require different urological surgical approaches. The literature recommendations for treatment are not uniform. Their prognosis is worse compared to the cutaneous melanoma, which may be due to clinical and pathological diagnostic difficulties. The latest targeted and immunotherapeutic agents can significantly improve the survival of metastatic patients. Orv Hetil. 2019; 160(10): 378–385.

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Metastatic malignant melanoma of the urinary bladder: A case report and review of the literature

Cited by 6 publications

References 0 publications

Metastatic Melanoma of the Bladder: A Case-Report and Literature Review

Metastatic Melanoma of the Bladder: A Case-Report and Literature Review

Urological Melanoma: A Comprehensive Review of a Rare Subclass of Mucosal Melanoma with Emphasis on Differential Diagnosis and Therapeutic Approaches

Urogenitalis lokalizációjú mucosamelanoma primer és áttétes esetei klinikánkon

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