Metastatic Lung Cancer to the Distal Finger Presenting as Osteomyelitis

Diramerian, Liza Garabet; Griffin, E. L.; Pendergrast, Kenneth; Arsura, Edward L.; Roberts, Marigny

doi:10.7759/cureus.11441

Cited by 6 publications

(6 citation statements)

References 11 publications

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“…The presence of metastasis to the forefoot (metatarsal bone or phalanx) is the rarest [ 4 ]. The clinical presentation of phalangeal metastasis is often mistaken with an osteomyelitis or a gouty arthritis, because of the erythema, pain, and swelling [ 7 ]. Other entities can also mimic an acrometastasis, such as ganglion cysts, acute paronychial infections, pyogenic granulomas, herpes zoster, tuberculous dactylitis, erysipelas, or some skin tumors, making the diagnosis quite challenging [ 2 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

Toe Acrometastasis as an Initial Sign of Metastasis in a Patient With a Large Cell Lung Carcinoma

Malhame¹,

Rachkidi²

2022

Cureus

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Acrometastases are rare lesions that originate most commonly from the primary lung cancer. They can mislead the diagnosis and the treatment, since they often appear as an osteomyelitis of the affected area. The presence of these metastases is a sign of poor prognosis, with a life expectancy of few months. We report a case of a 78-year-old male with an acrometastasis to the distal phalanx of the right fourth toe. It was the first sign that his previously diagnosed large cell lung carcinoma had reached a metastatic stage. Amputation of the toe was considered in this case where the intense pain of his acrometastasis could not be managed even with strong analgesics.

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Section: Discussionmentioning

confidence: 99%

Toe Acrometastasis as an Initial Sign of Metastasis in a Patient With a Large Cell Lung Carcinoma

Malhame¹,

Rachkidi²

2022

Cureus

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“…114 While individuals with isolated HL may experience bilateral, profound SNHL, those with Pendred syndrome may have concomitant HL, enlarged vestibular aqueduct and abnormal iodine organification. 115 Approximately 12.4% of HL cases in the Pakistani community can be attributed to SLC26A4. 66 While the majority of the identified variants are described as non-syndromic, especially in young individuals, the presence of Pendred syndrome may be frequently overlooked.…”

Section: Slc26a4mentioning

confidence: 99%

“…Variants in SLC26A4 (DFNB4) have been linked to both ARNSHL and Pendred syndrome 114 . While individuals with isolated HL may experience bilateral, profound SNHL, those with Pendred syndrome may have concomitant HL, enlarged vestibular aqueduct and abnormal iodine organification 115 . Approximately 12.4% of HL cases in the Pakistani community can be attributed to SLC26A4 66 .…”

Section: Recurrent Genes and Variants Associated With Hearing Loss In...mentioning

confidence: 99%

Autosomal recessive non‐syndromic hearing loss genes in Pakistan during the previous three decades

Shadab,

Abbasi,

Ejaz

et al. 2024

J Cellular Molecular Medi

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Hearing loss is a clinically and genetically heterogeneous disorder, with over 148 genes and 170 loci associated with its pathogenesis. The spectrum and frequency of causal variants vary across different genetic ancestries and are more prevalent in populations that practice consanguineous marriages. Pakistan has a rich history of autosomal recessive gene discovery related to non‐syndromic hearing loss. Since the first linkage analysis with a Pakistani family that led to the mapping of the DFNB1 locus on chromosome 13, 51 genes associated with this disorder have been identified in this population. Among these, 13 of the most prevalent genes, namely CDH23, CIB2, CLDN14, GJB2, HGF, MARVELD2, MYO7A, MYO15A, MSRB3, OTOF, SLC26A4, TMC1 and TMPRSS3, account for more than half of all cases of profound hearing loss, while the prevalence of other genes is less than 2% individually. In this review, we discuss the most common autosomal recessive non‐syndromic hearing loss genes in Pakistani individuals as well as the genetic mapping and sequencing approaches used to discover them. Furthermore, we identified enriched gene ontology terms and common pathways involved in these 51 autosomal recessive non‐syndromic hearing loss genes to gain a better understanding of the underlying mechanisms. Establishing a molecular understanding of the disorder may aid in reducing its future prevalence by enabling timely diagnostics and genetic counselling, leading to more effective clinical management and treatments of hearing loss.

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“…Physiopathological mechanisms to explain this particular dissemination process remain uncertain [ 8 , 9 ]. In fewer than 2.5% of lung cancers are BMs the first manifestation of neoplastic disease [ 10 ]. Few cases of AM of the hand as the initial disease presentation have been reported [ 7 , 11 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

Solitary acrometastasis of the phalanx as initial presentation of an oligometastatic Kirsten rat sarcoma viral oncogene homolog-mutated lung adenocarcinoma: a case report

Pușcașu,

Moinard-Butot,

Antoni

et al. 2023

J Med Case Reports

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Background Acrometastasis is an uncommon finding in non-small cell lung cancer and is usually a sign of multimetastatic disease. Few case reports have suggested solitary digital metastasis as the single secondary lesion of oligometastatic non-small cell lung cancer. Case presentation This case report describes an unusual presentation of a Kirsten rat sarcoma viral oncogene homolog-mutated lung adenocarcinoma with a solitary bone metastasis in the fourth finger medial phalanx, which was also the first sign of the disease, in a 63-year-old Caucasian female patient. Digital surgical amputation was performed. After histopathological confirmation and radiological exclusion of other secondary lesions, chemoimmunotherapy in a first-line setting was initiated. A partial metabolic response in the primary lung lesion was observed after four cycles. Maintenance therapy is currently being continued. Conclusion Solitary digital metastasis is a rare finding in non-small cell lung cancer. Further studies are needed to investigate the mechanisms behind this particular dissemination process.

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Metastatic Lung Cancer to the Distal Finger Presenting as Osteomyelitis

Cited by 6 publications

References 11 publications

Toe Acrometastasis as an Initial Sign of Metastasis in a Patient With a Large Cell Lung Carcinoma

Toe Acrometastasis as an Initial Sign of Metastasis in a Patient With a Large Cell Lung Carcinoma

Autosomal recessive non‐syndromic hearing loss genes in Pakistan during the previous three decades

Solitary acrometastasis of the phalanx as initial presentation of an oligometastatic Kirsten rat sarcoma viral oncogene homolog-mutated lung adenocarcinoma: a case report

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