Metastatic lobular carcinoma in a ThinPrep Pap test: Cytomorphology and differential diagnosis

Green, Kimberly M.; Turyan, Hach V.; Jones, Jennifer B.; Hoda, Rana S.

doi:10.1002/dc.20164

Cited by 12 publications

(7 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to our case, a routine Pap test necessitated further workup, revealing synchronous endometrial and cervical metastases 5 . A literature search of patients with cervical (with or without uterine) metastases of breast cancer revealed on Pap test (without or without co‐current cervical biopsy) identified a total of twenty‐four previously published cases; nine were ductal, and fourteen were lobular (one was not specified) 5‐23 . Cases with isolated cervical metastases and cases with disseminated metastatic disease with cervical involvement were reported.…”

Section: Discussionmentioning

confidence: 99%

Metastatic breast cancer diagnosed on cervical cytology

et al. 2020

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Metastatic breast cancer diagnosed on cervical cytology

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Metastatic colon cancer shows cigar‐shaped cells with hyperchromatic oval nuclei in palisaded arrangement in a background of clinging or clumped granular to necrotic diathesis. Lobular carcinoma of breast may metastasize to gynecologic tract 107. Cells are small, round with eccentrically placed small irregular nuclei with high N : C ratio arranged in small groups or in linear “Indian file” arrangement.…”

Section: Metastatic Adenocarcinomamentioning

confidence: 99%

Gynecologic cytology on conventional and liquid‐based preparations: A comprehensive review of similarities and differences

Hoda

Loukeris

Abdul‐Karim

2012

Diagnostic Cytopathology

Self Cite

View full text Add to dashboard Cite

Liquid-based preparations (LBPs) have largely replaced conventional Papanicolaou smears (CPS) for cervical samples in the United States and in many other industrialized countries. The two FDA-approved LBP currently in use include ThinPrep (TP), (Hologic Inc., Bedford, MA) and SurePath (SP), (BD Diagnostic, Burlington, NC). Split-sample and direct-to-vial studies have shown that LBPs show an overall improvement in sample collection and processing, reduce artifacts that interfere in diagnosis, are more sensitive, can be utilized for ancillary tests and are a cost-effective replacement for CPS. Comparative analyses of diagnostic accuracy indicate that LBPs perform at least as well as CPS. However, the added advantages of standardized, automated preparations and screening, reduced unsatisfactory rate, improved specimen adequacy and ability to perform human papillomavirus (HPV) test, are enough to continue use of LBP. The cytologic features in LBP are similar to CPS with subtle differences, particularly in background information. There are also subtle differences between the two LBPs, SP and TP, which are reflective of different sampling devices, collection media, and processing techniques. Architecturally, LBP shows smaller cell clusters and sheets and more dyscohesion. Cytologically, enhanced nuclear features and smaller cell size are more prominent. Advances in liquid-based Papanicolaou's (Pap) test have lead to well-defined patient management guidelines by the American Society for Colposcopy and Cervical Pathology. Herein, we review these aspects of Pap test including, morphology, automation, ancillary tests (HPV and immunochemistry), pertinent QA/QC monitors, patient management guidelines, and review of pertinent literature.

show abstract

“…14 Lobular carcinoma more frequently spreads to the genital tract than ductal carcinoma, especially tumours which are hormonal receptor positive. 15 There are previous case reports of metastatic lobular carcinoma in cervical cytology samples 1,[16][17][18][19] and a few of ductal carcinoma of the breast. 20,21 In the majority of cases the background is clean, as was seen in the present series.…”

Section: Discussionmentioning

confidence: 99%