“…Although most tumors cover the same steps of metastatic dissemination (i.e., extravasation, dissemination through blood or lymphatics, intravazation, and establishment in the metastatic niche), the time required to form overt lesions significantly differs according to the tissue of origin and cancer subtypes. While breast, prostate, renal cell cancers, as well as sarcomas and melanomas show long latency and the time required to develop metachronous metastasis might reach 15 years, 85% of relapses from colon cancer are detected within 3 years (medium latency), and lung cancers often spread at distant sites within a few weeks (short latency) ( 1 , 3 – 5 ). When the time required for a DCC to form an overt metastasis after the removal of the primary tumor is long (arbitrarily usually set as 5 years), latency is often referred to as “dormancy”.…”