Metastatic Intraocular Tumor Due to Colorectal Adenocarcinoma: Case Report and Literature Review

Abstract

Purpose: To describe the clinical and histopathological findings of a case of intraocular metastasis due to colorectal adenocarcinoma and to carry out a literature review.
 Case Report: A 64-year-old man with a history of tumor resection due to infiltrating colorectal adenocarcinoma three years previously sought ophthalmological care because of severe ocular pain without response to medical treatment and progressive vision loss in the left eye. On ultrasonographic examination, there was a heterogeneous intraocular choroidal tumor, which occupied approximately 40% of the vitreous cavity, as well as peritumoral serous retinal detachment. The patient underwent left eyeball enucleation. The histopathological diagnosis was metastatic tubular adenocarcinoma involving the retina and choroid that partially infiltrated the sclera and the proximal optic nerve.
 Conclusion: The present case highlights a rare pathological entity associated with variable therapeutic schemes and survival times and poor prognosis in patients with metastatic intraocular tumors due to colorectal adenocarcinoma.

Clinical Features of Retinal Metastases

“…At baseline, there were only three concurrent choroidal infiltrations (on histopathological analyses). [4][5][6] In our cohort, one clinical choroidal infiltration developed during follow-up. The mean tumor basal diameter was 4.9 mm (±3.3) and the mean thickness was 2.5 mm (±1.5).…”

“…endothelial growth factor (for three of our cases), plaque brachytherapy, 1 external beam radiotherapy, 16,21,[25][26][27][28][29][30] and enucleation. 1,[3][4][5][6]17,18,21,30 Management of patients with metastatic cancer is complex and is generally multidisciplinary because they are believed to have limited life expectancy, particularly in case of RM. However, considering palliative measures in such patients includes the preservation of vision and prevention of ocular pain, which is essential for end-oflife well-being.…”

Salivary Exosomes in Health and Disease: Future Prospects in the Eye

“…Colorectal cancer is the second cause of cancer-related deaths in Western countries, accounting for 9% of all cancer-related deaths [ 236 ]. While rare, several cases of intraocular metastasis from colorectal cancer exist, disseminating via the choroid [ 237 , 238 ].…”