Metastatic Hypernephroma of the Brain from a Neurosurgical Point of View

Störtebecker, Tore Patrick

doi:10.3171/jns.1951.8.2.0185

Cited by 50 publications

(7 citation statements)

References 11 publications

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“…The co llisio n tumou r is defined as a gr owth o f rwo isolated tumours fusing if they are growing together(20). In our case we had a ,21,23, 26, 32, 34 , 37), live fro m the kidney (2,22,28,36 ), three tro m th e pro state (3, 7, 9 ), rwo fro m the ut eru s (l7,…”

mentioning

confidence: 72%

Metastasis of lung Carcinoma to intracranial meningioma - Case report and review of literature

Conzen¹,

Sollmann²,

Schnabel³

1986

Minim Invasive Neurosurg

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mentioning

confidence: 72%

Metastasis of lung Carcinoma to intracranial meningioma - Case report and review of literature

Conzen¹,

Sollmann²,

Schnabel³

1986

Minim Invasive Neurosurg

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“…Only one example of glioblastoma and two of oligodendroglioma have so far been reported as harbouring metastatic tumour from respectively thyroid carcinoma, 1 2breast carcinoma, 1 3and melanoma. 4 Critical review of those reports suggests that only Strang's'3 case, that of a mammary carcinoma metastasising into an oligodendroglioma, is probably acceptable. However, anatomical verification is lacking in that case.…”

Section: Discussionmentioning

confidence: 99%

Metastatic carcinoma to glioma: a report of three cases with a critical review of the literature.

Mörk

Rubinstein

1988

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY Three cases are reported of primary bronchial carcinoma with metastatic deposits in an intracranial glioma (two cerebral astrocytomas and one fourth ventricle ependymoma). The rarity of this phenomenon is emphasised and the literature critically reviewed.Metastasis of cancer to cancer is a well-documented phenomenon, including the metastasis of a neoplasm originating outside the central nervous system into a primary intracranial tumour. In the great majority of the latter cases the intracranial tumour was a meningioma. 1-1oIn this paper we draw attention to the occasional development of a metastatic carcinomatous deposit in an intracranial glioma. Cases of this nature have so far seldom been completely or convincingly documented (see discussion). Three such unquestionable cases will be described. Case reportsCase 1 (C2940) Clinical summary A 44 year old male had experienced cough and fatigue for 2 months, when a biopsy from the lower lobe of the left lung revealed a primary bronchial carcinoma. A left pneumonectomy was performed. Three months later computed tomography and radionuclide scans disclosed metastic deposits in the liver and brain. Radiation to the brain was started, but the patient died from respiratory arrest 2 weeks later. Pathological findings Necropsy revealed multiple subpleural metastases in the right lung and numerous deposits in the right adrenal gland, liver and mesentery. Their microscopic features were those of a poorly differentiated meta- static adenocarcinoma consistent with a bronchial origin. In the central nervous system several round and finely granular lesions, about 10mm in diameter, were present bilaterally in the frontal lobes and cerebellar hemispheres. In addition a finely granular, velvety and somewhat shiny mass (measuring up to 5 cm in its largest diameter) was found in the wall of the anterior horn of the left lateral ventricle, anterior fornix, septum lucidum and genu of the corpus callosum. It extended into the right basal ganglia. Microscopically the large central cerebral lesion was mainly composed of diffusely infiltrating pleomorphic, occasionally multinucleated astrocytes with hyperchromatic nuclei, therefore typical of anaplastic astrocytoma. Within this glioma, a circumscribed tumour nodule composed of large cells with an epithelial trabecular arrangement, abundant cytoplasm and heavily stained, irregular nuclei was found. These cells were cytologically identical with the pulmonary bronchogenic carcinoma, thus constituting distinct islands of poorly differentiated adenocarcinoma in an anaplastic astrocytoma (fig 1). Other sections from the brain remote from the glioma showed the typical lesions of metastatic adenocarcinoma.Case 2 (C357) Clinical summary A 58 year old man developed signs of a posterior fossa tumour. A craniotomy revealed an ependymoma of the fourth ventricle. Following postoperative radiation, the patient remained well for 14 months. He then became lethargic and weak, and complained of anorexia and hoarseness. Neurological examination reveal...

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“…So wurden Patienten mit einer Hirnmetastase beschrieben, die 12 bzw. 14 Jahre nach Diagnose des Nierenzellkarzinoms noch in einem guten Zustand waren [4,17]. Ebenso sind Patienten bekannt, bei denen erst nach 16 Jahren eine 2.…”

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Erfolgreiche Langzeitbehandlung bei multiplen Hirnmetastasen eines Nierenzellkarzinoms

et al. 2002

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The case of a patient suffering from renal cell carcinoma and recurrent brain metastases shows how the survival period can be significantly prolonged by a combination of stereotactically guided percutaneous single-dose convergent beam irradiation and surgery. This 58-year-old man's left kidney was completely excised because of a renal cell carcinoma. After 18 months and 25 months, respectively, a right frontal brain metastasis was operated on. In the next 7 years, biannual MRI checks were carried out which successively showed five different brain metastases, each of which was immediately subjected to single-dose stereotactic irradiation (median dosage: 20 Gy prescribed to the 80% isodose). In the following 2 years, operations were carried out on two metastases which could not be treated by radiation because of their considerable size and partial compression of the ventricle. In the next 3 years, four more brain metastases were subjected to single-dose stereotactic irradiation. There were no metastases in the other organs. At present, the patient is in good clinical condition and mobile. A negative prognosis is usually delivered for patients suffering from renal cell carcinoma and brain metastasis. However, in individual cases, the survival period can be significantly prolonged by regular MRI examinations and a combination of neurosurgery and single-dose stereotactic irradiation.

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Metastatic Hypernephroma of the Brain from a Neurosurgical Point of View

Cited by 50 publications

References 11 publications

Metastasis of lung Carcinoma to intracranial meningioma - Case report and review of literature

Metastasis of lung Carcinoma to intracranial meningioma - Case report and review of literature

Metastatic carcinoma to glioma: a report of three cases with a critical review of the literature.

Erfolgreiche Langzeitbehandlung bei multiplen Hirnmetastasen eines Nierenzellkarzinoms

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