Metastatic Gestational Trophoblastic Disease: A Study of Institutional and Non‐Institutional Cases at the National Hospital for Women Philippines

Abstract

This study aims to find out the results of our management of metastatic trophoblastic disease as they occurred in our hospital from 1966 to 1975. Only those that originated from hydatidiform mole were selected (49 cases). Those that came from hydatidiform mole and were admitted as such were classified as institutional cases while those that were handled outside the institution were classified as non-institutional cases. Results showed that in institutional cases, mortality was 40% while in the non-institutional group, mortality was 65.5% with an average of 55.1% for both groups.Choriocarcinoma with metastasis gave the highest mortality rate. Analysis of the cases showed that the main cause of mortality was hemorrhage from the uterine or metastatic lesion in the genitals. The most common site of metastasis was the lungs.The significant factors determining the prognosis were the stage of the disease at initial presentation, and the quality of follow-ups, aside from the inherent characteristic behaviour of the trophoblast.