Metastatic gastric carcinoma from breast cancer mimicking primary linitis plastica: A case report

Yagi, Yasushi; Sasaki, Shin; Yoshikawa, Akira; Tsukioka, Yuji; Fukushima, Wataru; Fujimura, Takashi; Higuchi, Hisashi; Izumi, Ryohei; Saito, Katsuhiko

doi:10.3892/ol.2015.3788

Cited by 12 publications

(30 citation statements)

References 21 publications

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“…The most common histological pattern found in gastric metastasis is adenocarcinoma with signet ring cells; this pattern can be confused with primary gastric cancer, as said in the reviews; indeed in three case reports [37][38][39] preoperative findings showed this pattern on gastric biopsies and surgical treatment was performed.…”

Section: Part 3 Comparison Between Reviews and Case Reportsmentioning

confidence: 88%

“…Gastric metastases usually occur many years after primary breast cancer, so when the patient presents with these vague symptoms it's difficult to reconduct them to the primary causative disease. In our case reports, nine [23,28,29,35,37,38,39,43,45] of the patients had a wrong initial diagnosis and they were submitted to surgical treatment in the suspect of a primary gastric cancer.…”

Section: Symptomsmentioning

confidence: 91%

“…The preferred treatment is systemic therapy, as chemotherapy, endocrine therapy or a combination of both of them; 41 of the patients were subjected to chemotherapy with or without hormonal therapy. Combination of surgery and chemotherapy was used in 10 patients [23,28,29,35,[37][38][39]41,43,45] ; two of them [28,29] were submitted to neoadjuvant chemotherapy followed by surgery in the belief of a primary gastric cancer. Surgical treatment alone was chosen in 7 [26,27,42] patients, with three [27,42] of them in an emergency setting for bleeding and perforation.…”

Section: Therapymentioning

confidence: 99%

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Breast cancer metastasis to the stomach

D’Angelo¹,

Rampini²,

Cardella³

et al. 2019

JCMT

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Aim: This study focuses on the stomach as an unusual but not rare site of metastasis of breast cancer. Methods: We performed a literature search on gastric metastasis from breast cancer searching for reviews from 2000 to 2018 and case reports from 2013 to 2018. We found 11 reviews and 36 case reports and we compared their findings about important aspects of gastric metastasis, such as disease free survival, overall survival, symptoms, endoscopic findings, therapy, histology, and immunohistochemistry. Results: The incidence of stomach as site of metastasis of breast cancer ranges from 5% to 18%. Reviews and case reports reached similar conclusions about several of the aforementioned aspects: invasive lobular breast cancer (ILC) is mainly responsible for gastric metastases; disease free survival can vary greatly ranging from 0.5 months to 30 years; gastric metastases usually present with non-specific symptoms, even though five patients in case reports were asymptomatic; linitis plastica is the most common endoscopic finding; immunohistochemistry is essential for differentiating primary gastric cancer from metastasis; the preferred treatment is systemic therapy, but surgery is still an option in case of emergency; median overall survival of patients with gastric metastasis from breast cancer is 24 months. Conclusion: Breast metastasis to the stomach should be considered in any patient suspecting gastric neoplasm previously treated for breast carcinoma, especially if the treated carcinoma was ILC.

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Section: Part 3 Comparison Between Reviews and Case Reportsmentioning

confidence: 88%

Section: Symptomsmentioning

confidence: 91%

Section: Therapymentioning

confidence: 99%

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Breast cancer metastasis to the stomach

D’Angelo¹,

Rampini²,

Cardella³

et al. 2019

JCMT

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show abstract

“…On 2014, a systematic review on gastric metastases of different origin has been performed, including data of 4 case series and 2 case reports on breast cancer metastases in the stomach, accounting for a total of 95 patients (4). Our literature search found further 13 publications, including 5 case series and 8 case reports, with a total of 63 patients (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). Therefore, by adding our case, data of 159 patients with gastric metastasis from breast cancer are available.…”

Section: Literature Reviewmentioning

confidence: 99%

Gastric metastases from gynaecologic tumors: case reports and review of the literature

et al. 2016

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The stomach is an infrequent localization of tumor metastases, and metastases originating from primary gynaecological cancers are particularly rare. We described the case of three females with ovarian, uterine, and breast metastases in the stomach, and we performed a systematic review of the literature of cases diagnosed at endoscopy. Overall, data of 18 patients with gastric metastases originating from the ovary, 11 from the uterus, and 159 from breast cancer were analyzed. Therefore, gastric metastasis mainly occurs from breast cancer, whilst both ovarian and uterine metastases are distinctly less frequent, but not impossible.

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plasm and gastric metastasis from another organ may be difficult [3], and the conjugation of clinical history, endoscopic findings, histology, and immunohistochemistry is crucial [4].Our patient was a 77-year old female with hypertension, dyslipidemia, hypothyroidism, osteopenia, and a history of hysterectomy and bilateral oophorectomy due to uterine fibroids. She had a bilateral lobular breast carcinoma without distant metastasis (M0) in 1993, treated with right quadrantectomy (pT1N0), left radical mastectomy (pT4N1, with lymphatic invasion), bilateral adjuvant radiotherapy, and adjuvant hormonotherapy with tamoxifen during 5 years.

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mentioning

confidence: 99%