Metastatic Fibrosarcoma of the Brain: Transformation From Conventional to Epithelioid Form-Case Report-

Erguvan-Önal, Rezzan; Önal, Çağatay; Gürlek, Ali; Alkan, Alpay; Erkal, Haldun Şükrü; Mızrak, Bülent

doi:10.2176/nmc.44.497

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…Second category encompasses sarcomatous transformation of a preexisting brain tumor, such as meningioma or glioma. Third category includes radiation induced sarcomas and fourth category is composed of systemic metastatic sarcomas to the central nervous system [1–4, 6–8, 15–17]. Post irradiation fibrosarcoma of the central nervous system is characterized by quick and extensive local invasion of the tissues [1, 3].…”

Section: Discussionmentioning

confidence: 99%

Secondary fibrosarcoma of the brain stem treated with cyclophosphamide and Imatinib

2009

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Radiation-induced midbrain fibrosarcoma is a rare, highly aggressive tumor, which is associated with poor prognosis. We present the case of a 48-year old man with brainstem fibrosarcoma 20 years following radiation therapy received for a pituitary tumor. We discuss this case in the context of the diagnostic criteria for these tumors, and previous reports of secondary and primary sarcomas of the central nervous system.

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Section: Discussionmentioning

confidence: 99%

Secondary fibrosarcoma of the brain stem treated with cyclophosphamide and Imatinib

2009

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Surgical outcome and graded prognostic assessment of patients with brain metastasis from adult sarcoma: multi-institutional retrospective study in Japan

et al. 2020

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Background: Little information is available about the feasibility and prognostic assessment of surgical resection of brain metastasis (BM) from sarcomas. We aimed to analyze functional and survival outcomes, and develop a preoperative graded prognostic assessment (GPA) for patients with BM from sarcomas to predict survival time after local resection surgery. Methods: This study involved a multiinstitutional retrospective analysis of 22 patients with BM from sarcomas who underwent resection at six institutes in Japan between September 2002 and September 2018.Overall survival (OS) after resection of BM was calculated by the Kaplan-Meier method. Prognostic factors were analyzed to develop a GPA using the log-rank test and Cox regression analysis. P < 0.05 was considered to indicate statistical significance. For GPA validation, we collected data on 100 patients from 48 published reports. Results: Postoperative Karnofsky Performance Status (KPS) was improved in 50% (11/22) of patients. Median OS was 21 months. Univariate analysis of OS showed that age (≥ 30 years old), gross total resection, and alveolar soft part sarcoma (ASPS) were significant positive prognostic factors (P<0.05). Multivariate analysis of OS showed age and ASPS were significant preoperative prognostic factors (P<0.05). RTOG-RPA classification had no significant prognostic value. We developed a GPA system for survival time after resection of BM in our patients. A score of 0 was assigned to patients aged 18-29 years with non-ASPS, a score of 2 to patients aged 18-29 years with ASPS or those aged 30-76 years with non-ASPS, and a score of 4 to patients aged 30-76 years with ASPS. Median OS for patients with GPA scores of 0, 2, and 4 were 6.5, 16.0, and 44.0 months, respectively (P=0.002). The results were validated by the survival data of 100 patients compiled from the literature (P<0.001). Conclusion: Patients with BM from sarcomas surgically treated showed median survival comparable to that of patients with BM from carcinomas,and showed improvement in postoperative KPS.We developed a new GPA of patients with BM from sarcomas. These results may help patients and clinicians to select resection as a feasible option for treating BM from sarcomas. Background Adult sarcomas are an uncommon, heterogeneous entity of solid tumors of mesenchymal origin with various distinct histological subtypes, accounting for 1% of all adult malignancies [1].

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Clinical Characteristics and Surgical Features of Intracranial Fibrosarcoma

Peng

et al. 2020

Journal of Craniofacial Surgery

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Background: Intracranial fibrosarcoma is an extremely rare neoplasm in the central nervous system. Insofar there were only sporadic case reports describing its features. The purpose of this study is to review the clinical and surgical features of cases who were treated in our department. Method: The authors retrospectively reviewed and detailed the clinical and surgical data obtained from 5 patients with fibrosarcoma who underwent treatment at our institute between January 2009 and January 2019. Results: There were 3 males and 2 females including 2 juvenile and 3 senior patients. The most frequent sign was intermittent pain and vomiting. The location of the tumor included middle fossa, thalamus and midbrain, sellar and suprasellar region and right parietal-occipital lobe. Surgical observation demonstrated the consistency of the tumor was tenacious with abundant blood supply. Gross total resection was achieved in 2 cases. Pathological analysis showed spindle cells in a herringbone form with positive Vimentin staining in all 5 cases, with the absence of GFAP or S-100. All 5 patients were deceased eventually after a varied period of time after the first surgery. Conclusion: Intracranial fibrosarcoma was a highly malignant entity presented in the central nervous system. Surgery still remains the first-line treatment followed by radiotherapy, however, the prognostic outcome was very poor. Future studies should be more focused on accumulation of the relevant information on this disease thus hopefully in assisting to developing more optimized treatment.

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Metastatic Fibrosarcoma of the Brain: Transformation From Conventional to Epithelioid Form-Case Report-

Cited by 4 publications

References 7 publications

Secondary fibrosarcoma of the brain stem treated with cyclophosphamide and Imatinib

Secondary fibrosarcoma of the brain stem treated with cyclophosphamide and Imatinib

Surgical outcome and graded prognostic assessment of patients with brain metastasis from adult sarcoma: multi-institutional retrospective study in Japan

Clinical Characteristics and Surgical Features of Intracranial Fibrosarcoma

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