Metastatic Ewing's sarcoma to the skull: CNS involvement excluded by MRI

Amerongen, A. H. M. Taets ven; Kaiser, M. C.; Waal, F. C. De

doi:10.1007/bf02388171

Cited by 4 publications

(2 citation statements)

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“…Central nervous system involvement is rare and, if present, is usually seen in disseminated and advanced disease [27]. To date, only a few cases of PNET/ES metastatic to the skull or brain have been reported [27][28][29][30]. Such reported cases of PNET/ES with central nervous system metastasis had an aggressive course associated with pulmonary metastasis [27], none of which were primary cutaneous or subcutaneous in origin.…”

Section: Discussionmentioning

confidence: 99%

Primary Subcutaneous Primitive Neuroectodermal Tumor with Aggressive Behavior and an Unusual Karyotype: Case Report

et al. 2004

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Primitive neuroectodermal tumor/Ewing sarcoma (PNET/ES) rarely occurs in the skin and subcutaneous tissues. We present a case of a 16-year-old girl with primary cutaneous and subcutaneous PNET/ES of the abdominal wall. Despite wide local excision and chemotherapy, she rapidly developed cranial bone and brain metastases, followed by lung and skeletal metastases, and died shortly thereafter. The recurrent tumor exhibited light microscopic features of a small, round, blue cell tumor with intracytoplasmic glycogen. Immunohistochemical analysis showed positivity for CD99, CD56, S100, and glial fibrillary acid protein, and ultrastructural features included cytoplasmic glycogen and focal complex interdigitating synaptic junction-like cytoplasmic folds. Cytogenetic analysis of the relapsed tumor showed a complex karyotype: 47,XX,i(1)(q10), der(4)t(4;19) (q33 approximately q35;q13.1), + 8,t(15;17)(q24;p11.2 approximately p12),der(19)t (19;20)(q13.1;p11.2),der(22)t(20;22)(q13;q13). Cytogenetic, interphase fluorescence in situ hybridization, and molecular genetic analyses failed to show t(11:22) (q24;q12) or abnormalities of chromosome region 22q12. The clinical behavior and atypical and complex cytogenetic abnormalities exhibited by the tumor in this patient are unusual and represent the most aggressive end of the clinical spectrum of cutaneous and subcutaneous PNET/ES.

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Section: Discussionmentioning

confidence: 99%

Primary Subcutaneous Primitive Neuroectodermal Tumor with Aggressive Behavior and an Unusual Karyotype: Case Report

et al. 2004

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“…James Ewing's description of this tumor contains no information on the involvement of the central nervous system 2 . Since then many reports on the direct extension of the tumor to the skull and meninges have been published 1,[3][4][5] . This type of involvement is thought to occur in up to 56% of cases 1,7,8 .…”

Section: Introductionmentioning

confidence: 99%

Brain Metastases from Ewing's Sarcoma

Bekiesińska‐Figatowska¹,

Jurkiewicz

Raciborska³

2009

Neuroradiol J

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Ewing's sarcoma accounts for approximately 30% of primary malignant bone tumors, mainly in children and young adults. At the time of diagnosis many patients already have metastatic spread of the disease, most often to the lungs and skeletal system. Intracerebral metastases are rare - the reported incidence is up to 4.3%. We describe two cases of metastatic deposits within the brain tissue. Signal intensity of the lesions was similar to that of meningioma on all sequences. Strong homogenous enhancement after gadolinium administration was also similar to meningioma.

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