Metastatic epidural spinal cord compression

Surgical Treatment of Metastatic Spinal Tumors

“…Most cases of MESCC occur in patients with a previously diagnosed malignancy, although it can be the initial manifestation in approximately 20% of patients. 15,16 This is particularly the case with lung cancer, for which MESCC is the presenting manifestation of malignancy in 30% of cases. 15,16 Prostate cancer, breast cancer, and lung cancer each account for approximately 15% to 20% of MESCC cases; non-Hodgkin's lymphoma, renal cell carcinoma, and multiple myeloma account for 5% to 10%, with the remainder coming from colorectal, sarcoma, or unknown primary tumors.…”

“…15,16 This is particularly the case with lung cancer, for which MESCC is the presenting manifestation of malignancy in 30% of cases. 15,16 Prostate cancer, breast cancer, and lung cancer each account for approximately 15% to 20% of MESCC cases; non-Hodgkin's lymphoma, renal cell carcinoma, and multiple myeloma account for 5% to 10%, with the remainder coming from colorectal, sarcoma, or unknown primary tumors. 1,14,15,17 MESCC occurs in the thoracic spine in 60%, in the lumbosacral spine in 25%, and in the cervical spine in 15%, and this reflects the relative distribution of blood flow and bone mass in each of the spinal segments.…”

“…15,16 Prostate cancer, breast cancer, and lung cancer each account for approximately 15% to 20% of MESCC cases; non-Hodgkin's lymphoma, renal cell carcinoma, and multiple myeloma account for 5% to 10%, with the remainder coming from colorectal, sarcoma, or unknown primary tumors. 1,14,15,17 MESCC occurs in the thoracic spine in 60%, in the lumbosacral spine in 25%, and in the cervical spine in 15%, and this reflects the relative distribution of blood flow and bone mass in each of the spinal segments. 1,14,15 Back pain is present in 95% of patients at the time of diagnosis and is typically but not universally worse at night or when the patient is recumbent.…”

“…1,14,15,17 MESCC occurs in the thoracic spine in 60%, in the lumbosacral spine in 25%, and in the cervical spine in 15%, and this reflects the relative distribution of blood flow and bone mass in each of the spinal segments. 1,14,15 Back pain is present in 95% of patients at the time of diagnosis and is typically but not universally worse at night or when the patient is recumbent. 15,17 Pain made worse with movement is suggestive of mechanical instability and is classically associated with pathological compression fractures and spinal deformity.…”

“…1,14,15 Back pain is present in 95% of patients at the time of diagnosis and is typically but not universally worse at night or when the patient is recumbent. 15,17 Pain made worse with movement is suggestive of mechanical instability and is classically associated with pathological compression fractures and spinal deformity. Weakness is the second most common symptomatic manifestation of MESCC.…”