Metastatic Epidermotropic Squamous Carcinoma Histologically Simulating Primary Carcinoma

Sporotrichoid Metastases to the Skin From Cutaneous Squamous Cell Carcinoma in an Immunocompetent Patient

“…7 Youngberg et al, 8 combined this hypothesis to Kato's one and suggested that the rarity of this epidermotropic type of metastasis, compared with the incidence of retrograde lymphatic metastasis of malignancy, together with the finding of an incontinuity ''smooth connection'' type of epidermotropism might support the hypothesis of an epidermotropism due to an inherent property of the neoplastic cell, rather than a random event.…”

“…In the past 20 years, several cases of cutaneous epidermotropic metastases of SCC of the skin, mimicking second primary SCC, have been reported. [7][8][9] In these cases, the metastases presented the fusion of benign squamous epithelium with malignant squamous epithelium.…”

Epidermotropic metastasis from vulvar squamous cell carcinoma: A rare cutaneous manifestation

“…However, cases of metastatic epidermotropism suggest that this distinction does not exist, and there appears to be continuity between malignant and benign cells in epidermotropic metastases. 15,25 It has been postulated that this phenomenon is due to the natural tendency of squamous epithelial cells to repair a denuded epithelial surface. 26 Clues to identifying primary versus secondary SCC include evidence of malignant cells in blood and/or lymphatic vessels and multiple cutaneous lesions appearing synchronously.…”

Fine Needle Aspiration Cytology of Metastatic Skin Nodules

“…6 The metastatic dermal nodules occasionally invade the overlying epidermis, simulating the appearance of a primary tumor (epidermotropic carcinomas). 7,8 The skin metastases tend to be close to the site of the primary tumor: chest in lung carcinoma, abdominal wall in gastrointestinal tumors and lower back in renal cell carcinoma. 1 Gupta and Naran reported on 146 patients with cutaneous/subcutaneous metastatic deposits from epithelial malignancies; in 135 cases there was a previous history of carcinoma.…”