Metastatic eccrine porocarcinoma: report of a case and review of the literature

Abstract

Eccrine porocarcinoma (EPC) is a rare type of skin cancer arising from the intraepidermal portion of eccrine sweat glands or acrosyringium, representing 0.005-0.01% of all cutaneous tumors. About 20% of EPC will recur and about 20% will metastasize to regional lymph nodes. There is a mortality rate of 67% in patients with lymph node metastases. Although rare, the occurrence of distant metastases has been reported.We report a case of patient with EPC of the left arm, with axillary nodal involvement and subsequent local relapse, treated by complete lymph node dissection and electrochemotherapy (ECT).EPC is an unusual tumor to diagnose. Neither chemotherapy nor radiation therapy has been proven to be of clinical benefit in treating metastatic disease. Although in the current case the short follow-up period is a limitation, we consider in the management of EPC a therapeutic approach involving surgery and ECT, because of its aggressive potential for loregional metastatic spread.

Clinical, Dermoscopic and Histopathological Features of Eccrine Poroid Neoplasms

“…It is considered a rare tumor with an estimated incidence in Europe of less than 0.3/ 100,000; to date a total of 300 cases have been reported in the literature [22,23,24]. …”

Eccrine porocarcinoma: a case report and brief review of the literature

“…The prognosis of this tumor is still questionable but recent reports have predicted more indolent behaviors [8]. Several metastatic tumors have been reported especially in primarily misdiagnosed cases [9][10][11]. In another report, half of the patients had inaccurate primary diagnosis [12].The most important differential diagnoses of EPC are inflamed poroma, Bowen ' s disease, Paget's disease, amelanotic melanoma, metastatic adenocarcinoma.…”

“…Due to lymphatic spread of EPC, sentinel lymph node biopsy might help us to detect subclinical lymph node involvement [8] but the role of lymphadenectomy is still questionable [2]. Chemotherapy and radiation have no place in treating metastatic disease [9].…”

Eccrine Porocarcinoma of the Scalp: A Case Report and Review of Literature

“…It accounts for 0.005-0.01% of all skin tumors with potential for local destruction and metastasis [1,2]. It is the malignant form of eccrine poroma, a common benign skin tumour of sweat glands [3]. Scalp is a rare site for EPC with a very few cases reported in the literature [1,3].…”

“…It is the malignant form of eccrine poroma, a common benign skin tumour of sweat glands [3]. Scalp is a rare site for EPC with a very few cases reported in the literature [1,3]. EPC may develop de novo or as a result of malignant transformation of eccrine poroma [4].…”