Metastatic Ductal Carcinoma of the Parotid Gland in a Patient With Sarcoidosis

Pollock, Jeffrey L.

doi:10.1001/archderm.1979.04010090048024

Cited by 13 publications

(5 citation statements)

References 2 publications

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“…Including our cases, to the best of our knowledge, there have been only 44 reported parotid neoplasm cases with cutaneous metastasis in the English literature (Table 1). 9–48 In this review, most patients were men (66%), with a mean age at diagnosis or appearance of parotid neoplasm of 49.2 years, which is similar to parotid carcinomas epidemiology. 1…”

Section: Discussionmentioning

confidence: 52%

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Cutaneous Metastasis From Parotid Tumors: A Report of 2 Cases and Literature Review

Puerto

Jaque

González-Bombardiere³

et al. 2021

The American Journal of Dermatopathology

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Cutaneous metastases from parotid tumors are uncommon and imply a poor prognosis. In this article, we report 2 new cutaneous metastasis cases from 2 different parotid malignancies and 42 additional cases from a literature review. Clinical manifestations, localization, and outcomes of skin metastasis from parotid tumors are described. Although infrequent, parotid neoplasms may develop skin metastasis many years after the initial diagnosis, mostly in the head and neck region. Therefore, long-term follow-up and periodic skin examination of these patients is mandatory. Dermatologists and surgeons must have a high index of suspicion when evaluating any skin lesion arising on these patients because cutaneous metastasis from parotid neoplasms generally implies a poor prognosis.

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Section: Discussionmentioning

confidence: 52%

“…According to a PubMed and Ovid database search, only 42 cases of cutaneous metastases from parotid neoplasms have been reported since 1956 (search date January 1, 1956, to July 31, 2020). 9–48 We describe 2 cases of parotid malignancies with cutaneous metastasis and a literature review of cutaneous metastasis from parotid tumors.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Metastasis From Parotid Tumors: A Report of 2 Cases and Literature Review

Puerto

Jaque

González-Bombardiere³

et al. 2021

The American Journal of Dermatopathology

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“…Salivary duct carcinoma is a rare malignancy derived from the parotid glands; to our best knowledge, only six salivary duct carcinoma patients with cutaneous metastases have been described: five men and one woman [9,[14][15][16][17][18][19]. Two of the men, whose clinical features of their cutaneous metastases have been described in this review, had carcinoma hemorrhagiectoides.…”

Section: Specific Tumor-associated Cutaneous Metastases Morphologiesmentioning

confidence: 91%

“…Two of the other men's salivary duct carcinoma skin metastases presented as subcutaneous nodules that were either skin-colored on the scapula and suprapatellar areas or zosteriform and linearly distributed on the chest and neck [16][17][18]. The fifth man's salivary duct carcinoma cutaneous metastasis presented as a superficial ulcer on his forehead mimicking a basal cell carcinoma and was treated by curettage; the nonhealing wound was excised and the diagnosis of salivary duct carcinoma skin metastasis was established [14].…”

Section: Specific Tumor-associated Cutaneous Metastases Morphologiesmentioning

confidence: 99%

“…Typically, when they do appear, it is in the setting of an oncology patient whose visceral malignancy is progressing. However, albeit less often, they may be either the initial presentation of malignancy in a previously cancer-free individual or the heralding sign of cancer recurrence in a patient whose malignancy had been in remission [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous Metastatic Cancer: Carcinoma Hemorrhagiectoides Presenting as the Shield Sign

Cohen¹,

Kurzrock²

2021

Cureus

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Cutaneous metastases can be either the initial presentation of an unsuspected internal neoplasm in a cancer-free individual, or the harbinger of recurrent malignancy in an oncology patient who had achieved remission of his cancer, or a sign of progressive disease in a cancer patient who is currently receiving antineoplastic treatment. The cutaneous presentation of skin metastases is pleomorphic and can mimic not only benign conditions and tumors of the skin but also infections and inflammation of the skin. Carcinoma erysipelatoides, carcinoma hemorrhagiectoides, and carcinoma telangiectoides are the three subtypes of inflammatory cutaneous metastatic cancer. The former masquerades as a cutaneous streptococcal infection whereas the latter mimics idiopathic telangiectasias. In contrast, the morphology of carcinoma hemorrhagiectoides is distinctive: it appears similar in shape to a medieval knight’s shield and its presence is referred to as a positive shield sign. To the best of our knowledge, carcinoma hemorrhagiectoides has been reported in four oncology patients whose skin metastases presented with the shield sign: two men with salivary duct carcinoma and two women with breast cancer. In conclusion, the shield sign may not only be a pathognomonic clinical feature of carcinoma hemorrhagiectoides but also reflect a common genomic aberration of these metastatic tumors.

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Cytologic characteristics and histomorphologic correlations of 21 salivary duct carcinomas

Klijanienko

Vielh

1998

Diagn. Cytopathol.

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Fine‐needle samplings (FNS) of 21 salivary duct carcinomas, histologically correlated, including 19 primaries, one local recurrence, and one lymph node metastasis from 19 patients, are reported. Cytologic diagnosis of high‐grade adenocarcinoma was established in 15 (71%). Five (24%) cases were misclassified as high‐grade mucoepidermoid carcinomas and one (5%) as squamous‐cell carcinoma. The histologic evaluation in all cases showed cytomorphologic features resembling mammary duct carcinoma with marked cytonuclear atypia and occasional oncocytic appearance. Our cytohistologic correlations indicate that irregular clusters of high‐grade adenocarcinoma cells with necrotic background and oncocytic features suggest a cytologic diagnosis of either primary salivary duct carcinoma or metastatic mammary carcinoma. Diagn. Cytopathol. 1998;19:333–337. © 1998 Wiley‐Liss, Inc.

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Metastatic Ductal Carcinoma of the Parotid Gland in a Patient With Sarcoidosis

Cited by 13 publications

References 2 publications

Cutaneous Metastasis From Parotid Tumors: A Report of 2 Cases and Literature Review

Cutaneous Metastasis From Parotid Tumors: A Report of 2 Cases and Literature Review

Cutaneous Metastatic Cancer: Carcinoma Hemorrhagiectoides Presenting as the Shield Sign

Cytologic characteristics and histomorphologic correlations of 21 salivary duct carcinomas

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