Metastatic Disease to the Breast From Extramammary Malignancies: A Multimodality Pictorial Review

Sippo, Dorothy A.; Kulkarni, Kiran Abhijit; Carlo, Philip Di; Lee, Bonmyong; Eisner, David; Cimino‐Mathews, Ashley; Harvey, Susan C.

doi:10.1067/j.cpradiol.2015.07.001

Cited by 46 publications

(41 citation statements)

References 12 publications

(17 reference statements)

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“…Margins could also be microlobulated or indistinct. Calcifications are not usually present and occur generally in patients with ovarian cancer due to the presence of psammomatous bodies [8] , [9] , [10] , [11] , but in our case no microcalcifications were observed. As in mammography, most metastatic lesions present on ultrasound as round or oval masses, with circuscribed, insistinct or microlobulated margins.…”

Section: Discussioncontrasting

confidence: 60%

“…Generally, hematogenous disseminated lesions are circumscribed masses and may mimic benign masses, as occur in our case, or circumscribed malignant tumors (ie mucinous or papillary carcinoma). Instead lymphatic dissemination may lead to diffuse breast involvement, edema, trabecular thickening, and skin thickening which may mimic inflammatory process such as mastitis or inflammatory carcinoma [8] .…”

Section: Discussionmentioning

confidence: 99%

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Breast metastasis from ovarian cancer: A case report

Latronico

Faggian

Nicosia

et al. 2018

Radiology Case Reports

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Breast metastasis from ovarian cancer is a rare event, with vary clinical and imaging presentations, depends on the form of dissemination of the disease and may mimic primary benign and malignant lesions.Confirmation of the diagnosis is of pivotal importance to choice an adequate therapeutic planning, allowing to avoid unnecessary surgeries and to provide appropriate systemic therapy. In this manuscript, we present a case of breast metastasis from ovarian cancer. The patient presented to our Institute with a localized, palpable mass in the upper outer quadrant of the right breast. Mammography and breast sonography showed a singular, round, and homogenous mass with regular borders. No suspicious axillary node was observed. Lesion biopsy revealed the presence of epithelial malignant tumor cells, compatible with a tube-ovarian serous histotype. So, although it could be rare, secondary malignant neoplasm should be considered in the differential diagnosis of breast lesions in patients with a personal history of ovarian cancer.

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Breast metastasis from ovarian cancer: A case report

Latronico

Faggian

Nicosia

et al. 2018

Radiology Case Reports

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“…Metastasis to the breast may occur in various types of non-breast solid tumor; however, cases of this are extremely rare ( 1 – 5 , 10 ). Additionally, the therapeutic strategies used to treat these cases are extremely different from those used to treat primary breast cancer, making the history of the primary tumor particularly important for the achievement of an accurate diagnosis ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

“…Previous ultrasonic and mammographic images studies demonstrated that it is occasionally difficult to distinguish breast metastases, which appeared as a hypoechoic or high-density well-circumscribed and freely movable mass, from primary breast cancer which displays a hypoechoic mass with speculated margin or a diffuse lesions with or without calcifications ( 5 , 18 , 19 ). However, despite the absence of diffuse lesions, 42.9% of the patients in the current study presented with a mass with a speculated margin.…”

Section: Discussionmentioning

confidence: 99%

“…To date, <500 cases of cancer with secondary involvement of the breast from any non-breast solid tumors have been reported ( 2 , 3 ). On the basis of the limited number of studies available in the literature, excluding contralateral breast cancer and lymphoma, the most frequent source of primary malignancies with metastases to the breast in Western countries are melanoma and lung cancer ( 3 – 5 ). Other reported primary sources include the ovary, gastrointestinal tract, thyroid, kidney and sarcomas of different origins ( 6 – 8 ).…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of breast metastases from non-breast solid tumors in 22ï¿½patients from a southern Chinese population

Sun

Chen

et al. 2018

Oncol Lett

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Breast metastases from solid non-breast tumor types are rare; however, they should be always considered in the differential diagnosis of a breast lesion owing to the associated poor patient prognosis and the requirement of different therapeutic strategies compared with those used to treat primary breast cancer. The aim of the current study was to summarize the characteristics of metastases to the breast in a southern Chinese population. The medical records and pathological sections of 22 patients with pathologically confirmed extra-mammary metastases to the breast that presented to Sun Yat-sen University Cancer Center between January 2000 and December 2015 were retrospectively reviewed. The median age of onset for breast metastasis was 43 years (range, 10–62 years) and 19 (86.4%) patients had a known history of a primary tumor. The mean interval from diagnosis of the primary tumor to breast metastasis was 16.5 months (range, 6–56 months). A unilateral (45.5% left, 36.4% right), upper outer quadrant (15/22, 68.2%) lesion of the breast was most frequently initially detected by self-checking (63.6%). The most common origin of the primary tumor was the lung (22.7%). Nasopharyngeal carcinoma accounted for a high proportion of the metastases (18.2%). The median duration of survival from the time of diagnosis of a breast metastasis was 14 months (range, 2–74 months). A total of 10 patients (45.5%) succumbed to the disease. The results also indicated that overall survival in patients that underwent surgery was improved compared with patients who did not undergo surgery. The results of the present study demonstrated that clinical history, imaging findings, pathology from the primary tumor and immunostaining were required in combination to establish an accurate diagnosis. Further investigation into the improvement of the prognosis of patients with metastases to the breast following surgery is required.

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