Metastatic Disease to a Concurrent Thyroid Neoplasm: A Case Series and Review of the Literature

Garneau, Michael; Alyzadneh, Eyas; Lal, Geeta; Kd, Anand Rajan

doi:10.1007/s12105-022-01509-7

Cited by 2 publications

(3 citation statements)

References 72 publications

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“…Other considerations, although uncommon, include the differentiation of MUF from “tumor‐to‐tumor metastasis”; which may also present with divergent morphology (metastatic deposit with its respective histopathology) in a thyroid neoplasm 31,32 …”

Section: Discussionmentioning

confidence: 99%

“…Other considerations, although uncommon, include the differentiation of MUF from "tumor-to-tumor metastasis"; which may also present with divergent morphology (metastatic deposit with its respective histopathology) in a thyroid neoplasm. 31,32 Chronic lymphocytic thyroiditis Among the presented patient cases with MUF, almost half had a background of CLT. In comparison: in other studies, 0.5%-38% of PTC had coexistent CLT, [33][34][35][36] and in the recent MASTER study on approximately thousand low to intermediate-risk PTC patients, 10% had coexistent CLT, while multifocality was an independent factor associated with CLT.…”

Section: Considerations Regarding the Identification Of Muf: Molecula...mentioning

confidence: 99%

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Multi‐UniFocality (MUF), in contrast to multifocality, in thyroid lesions: Relation to lymphocytic thyroiditis

Aydemirli,

Morreau

2024

Pathology International

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Whereas multifocality typically concerns papillary thyroid carcinoma (PTC) without specification of intrathyroidal metastatic or independent nature of tumor foci, the designation of the latter as Multi‐UniFocal (MUF) may be relevant for select cases. A case series involving multifocal thyroid lesions with divergent histopathological morphology and/or molecular profile, with molecular evaluation of multiple individual tumor foci per patient based on a next‐generation sequencing approach, was retrospectively reviewed. Twenty‐five patient cases with multifocal thyroid lesions suggestive of MUF, with 2–6 (median 3) tumor foci per patient, were described. Tumor lesions comprised diverse histopathology, including PTC, (E)FVPTC, NIFTP, FA, FTC, and oncocytic. Morphologically similar and/or diverse tumor foci harbored different molecular alterations (suggestive of non‐shared clonality); with(out) coexistent similar foci harboring identical molecular alterations; or (partly) shared molecular alterations. MUF was associated with chronic lymphocytic thyroiditis in almost half of the cases. The recognition of MUF may justify the independent clinical consideration per individual tumor focus; as separate lesions albeit within a multifocal context. The potential clinical relevance and prognostic value of MUF remain to be further established.

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Section: Discussionmentioning

confidence: 99%

Section: Considerations Regarding the Identification Of Muf: Molecula...mentioning

confidence: 99%

Multi‐UniFocality (MUF), in contrast to multifocality, in thyroid lesions: Relation to lymphocytic thyroiditis

Aydemirli,

Morreau

2024

Pathology International

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“…Around 1% of all thyroid neoplasms are considered to be of metastatic origin [ 1 ]. Lung, breast, and renal carcinomas are the common sources of metastases to the thyroid [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Recurrent Metastatic Colorectal Adenocarcinoma to the Thyroid Gland Presenting With Vocal Cord Paralysis and Inspiratory Stridor

Le¹

2023

Cureus

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The most common sites for metastases of colorectal cancer include the liver, lungs, brain, and regional lymph nodes. However, a limited number of reported cases describe colon cancer metastasis to the thyroid gland. Metastatic colorectal adenocarcinoma to the thyroid gland is rare. The majority of these cases with colon cancer metastases to the thyroid gland are diagnosed years after initial treatment of colon cancer. The discovery is usually made after routine surveillance imaging, and often patients have minimal or absent symptoms. We report a case of a recurrence of metastatic colorectal adenocarcinoma to the thyroid gland presenting with vocal cord paralysis and inspiratory stridor.

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Metastatic Disease to a Concurrent Thyroid Neoplasm: A Case Series and Review of the Literature

Cited by 2 publications

References 72 publications

Multi‐UniFocality (MUF), in contrast to multifocality, in thyroid lesions: Relation to lymphocytic thyroiditis

Multi‐UniFocality (MUF), in contrast to multifocality, in thyroid lesions: Relation to lymphocytic thyroiditis

Recurrent Metastatic Colorectal Adenocarcinoma to the Thyroid Gland Presenting With Vocal Cord Paralysis and Inspiratory Stridor

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