Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma

Tomar, Ankit Singh; Finger, Paul T.; Gallie, Brenda L.; Kivelä, Tero; Mallipatna, Ashwin; Zhang, Chengyue; Zhao, Junyang; Wilson, Matthew W.; Brennan, Rachel C.; Burges, Michala; Kim, Jonathan; Berry, Jesse L.; Jubran, Rima; Khetan, Vikas; Ganesan, Suganeswari; Yarovoy, А.А.; Yarovaya, V.А.; Kotova, E.S.; Volodin, D.P.; Yousef, Yacoub A.; Nummi, Kalle; Ushakova, Tatiana L.; Yugay, Olga V.; Polyakov, V.G.; Ramirez-Ortiz, Marco A.; Esparza-Aguiar, Elizabeth; Chantada, Guillermo; Schaiquevich, Paula; Fandiño, Adriana; Yam, Jason C.; Lau, Winnie W. Y.; Lam, Carol P.; Sharwood, Phillipa; Moorthy, Sonia; Long, Quah Boon; Essuman, Vera Adobea; Renner, Lorna; Semenova, Ekaterina A.; Català‐Mora, Jaume; Correa-Llano, Genoveva; Carreras, Elisa

doi:10.1016/j.ophtha.2022.04.022

Cited by 11 publications

(7 citation statements)

References 28 publications

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“…The type of studies included focused group discussions, surveys, retrospective, prospective studies, and mixed method studies. Some studies were brought forward by dedicated groups such as Retinoblastoma International Collaborative Study Group, 8 Global Retinoblastoma Study Group, [9][10][11][12][13][14][15][16][17][18][19] American Academy of Ophthalmology-Ocular Oncology Taskforce (AAO-OOT), [20][21][22][23][24][25] Children's Oncology Group (COG), 26 and Global Health Research Group. 27,28 Overall, participating centres were located in Africa, Asia, Australia, North America, South America, and Europe; and from lowerincome, lower-middle-income, higher-middle-income, and high-income countries based on the nation's gross domestic product (GDP).…”

Section: Resultsmentioning

confidence: 99%

“…Thus, AJCC stage and AJCC OOT grouping were both predictive of survival (Table 3). 23 Eyes with vitreous or subretinal seeds in RB are categorised as AJCC class cT2b but this does not take into account the type or extent of seeds. 36 Until the advent of intravitreal chemotherapy, vitreous seeds were a challenge to tackle leading to poor chances of globe salvage.…”

Section: Conclusion and Extrapolationmentioning

confidence: 99%

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Global retinoblastoma studies: A review

Vempuluru,

Maniar,

Kaliki

2024

Clinical Exper Ophthalmology

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In the current era of global health awareness for retinoblastoma (RB), the challenge that lies ahead of us is providing optimal care for children affected with RB in underdeveloped nations. The understanding of similarities and disparities between various nations across the world aids in achieving comparable outcomes. With dissolving geographic barriers and evolving collaboration, global collaborative studies on RB are becoming increasingly common. They provide real‐world, robust evidence on several aspects of RB. This review discusses insights gained from global RB studies regarding the demographics, certain aspects of etiopathogenesis and epidemiology, international travel burden, disparities in clinical presentations based on national income levels, management protocols, pathology, treatment outcomes, and the effect of COVID‐19 on RB care across the world. These insights are likely to impact individual practice as well as inform policy reforms.

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Section: Resultsmentioning

confidence: 99%

Section: Conclusion and Extrapolationmentioning

confidence: 99%

Global retinoblastoma studies: A review

Vempuluru,

Maniar,

Kaliki

2024

Clinical Exper Ophthalmology

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“…The American Joint Committee on Cancer Ophthalmic Oncology Task Force analyzed data from a multicenter, international, internet-based registry to determine the risk of metastatic death from advanced intraocular Rb at initial diagnosis. They found that the risk of metastatic mortality correspondently rose with increasing cT subcategory ( p < 0.001) and that primary enucleation offered the highest survival rates for patients with advanced intraocular Rb ( 31 ). Similarly, in our series, no single patient who had the most-advanced tumor in group T1 developed metastasis, but 21% of patients with T3 eyes developed metastasis.…”

Section: Discussionmentioning

confidence: 99%

Causes of death and survival analysis for patients with retinoblastoma in Jordan

Bilbeisi,

Almasry,

Obeidat

et al. 2023

Front. Med.

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PurposeTo analyze causes and prognostic factors for death among Retinoblastoma (Rb) patients treated at a single specialized tertiary cancer center in Jordan.MethodsWe reviewed the mortality causes for all Rb patients who have been treated at the King Hussein Cancer Center between 2003 and 2019 and were followed for at least 3 years after diagnosis. The main outcome measures included demographics, laterality, tumor stage, treatment modalities, metastasis, survival, and causes of death.ResultsTwenty-four (5%) of the 478 patients died from retinoblastoma and 5-year survival was 94%. The mean age at diagnosis was 15 months (median, 18 months; range, 4–38 months); eight (33%) received diagnoses within the first year of life. Eleven (46%) were boys, 16 (67%) had bilateral disease, and 3 (13%) had a positive family history. The stage for the worst eye was C for 1 (4%) patient, D in 6 (25%) patients, and E (T3) in 15 (63%) patients. Two patients had extraocular Rb at diagnosis, and four of the patients who had intraocular Rb at diagnosis refused treatment and then came back with extraocular Rb. In total, extraocular disease was encountered in six eyes (six patients). After a 120-month median follow-up period, 24 patients (5%) died of second neoplasms (n = 3) or metastases (n = 21). Significant predictive factors for metastasis and death included advanced IIRC tumor stage (p < 0.0001), the presence of high-risk pathological features in the enucleated eyes (p = 0.013), parental refusal of the recommended primary treatment plan (p < 0.0001), and extraocular extension (p < 0.0001).ConclusionThe 5-year survival rates of Rb patients in Jordan are as high as those in high-income countries. However, 5% are still dying from metastatic disease, prompting the need for awareness campaigns to educate the public about the high cure rates and to prevent treatment abandonment.

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“…IORB emerges in one or even both eyes and would be found only in the retina or in other eye portions such as the choroid, ciliary body, or in optic nerve. Tumor has not dispersed to the tissues encompassing the eye or to other body parts in IORB [7]. But cancer has dispersed beyond the eye in EORB.…”

Section: Hereditary / Congenitalmentioning

confidence: 99%

Retinoblastoma

Aneesh

Muneeswaran

2022

ijhs

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Eye cancer is extremely rare. It can harm the eye's outer parts, such as the eyelid, which is made up of muscles, skin, and nerves. Intraocular cancer occurs when cancer begins inside the eyeball. Melanoma and lymphoma are perhaps the very familiar intraocular cancers in grown-up person. Retinoblastoma, which begins in the cells of the retina, seems to be the most common type of eye cancer in children. Cancer can also disperse from several other parts of the human body to the eye. Therapies for eye cancer vary depending on the type and stage of the disease. Radiation therapy, Surgery, laser therapy, and freezing or heat therapy are all the possibilities. Medical imaging techniques such as Ultrasound, Magnetic Resonance Imaging and Computed Tomography supports in obtaining the anatomical structure of the eye. By the introduction of the image segmentation algorithms, the infected portion in the eye image is segmented and the information such as the size and location of the tumor is also identified. This can assist the clinicians make more rapid and accurate diagnosis. The various studies using conventional segmentation methodologies on Retinoblastoma were reviewed in this paper.

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Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma

Cited by 11 publications

References 28 publications

Global retinoblastoma studies: A review

Global retinoblastoma studies: A review

Causes of death and survival analysis for patients with retinoblastoma in Jordan

Retinoblastoma

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