Metastatic cystosarcoma phyllodes.A light and electron microscopic study

Fernandez, Balbino B.; Hernandez, Felix J.; Spindler, Wolfgang

doi:10.1002/1097-0142(197604)37:4<1737::aid-cncr2820370419>3.0.co;2-s

Cited by 30 publications

(13 citation statements)

References 12 publications

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“…In fact, only the stromal cells potentiate to metastasise. 26 Unlike phyllodes tumours, fibroadenomas have a true capsule. According to Azzopardi and Salvadori, they had proposed a widely acceptable definitions for phyllodes tumour between benign, borderline and malignant type.…”

Section: Diagnosismentioning

confidence: 99%

Approaches to phyllodes tumour of the breast: a review article

et al. 2017

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Phyllodes tumours are rare entities of fibroepithelial diseases. The exact pathogenesis and their relationship with fibroadenomas are oblivious. Women aged between 35 to 55 years are commonly affected, even younger in Asian population. Triple assessment should be applied as a guide to management in any breast pathology. Clinical appearances are typically diagnostic for phyllodes tumours. Even though sometimes inconclusive, mammography and ultrasonography are the main imaging modalities. Although the role of cytology is debatable, presence of both epithelial and stromal elements supports the diagnosis especially in malignant type. Core biopsy is rather favored in view of higher accuracy for the diagnosis. Accurate preoperative assessment and histologic diagnosis allow correct surgical intervention and subsequent avoidance of reoperation. Surgical management can be either wide excision with more than 1 cm margins or mastectomy without axillary surgery. Local recurrence has been associated with inadequate excision of the pseudopod. Adjuvant radiotherapy is recommended for positive surgical margin and for local control of borderline and malignant phyllodes tumors. The role of chemotherapy and endocrine therapy has not been fully studied.

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Section: Diagnosismentioning

confidence: 99%

Approaches to phyllodes tumour of the breast: a review article

et al. 2017

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“…The stroma is the neoplastic component and determines the pathological behaviour 49. Only the stromal cells have the potential to metastasise 50. Primary tumours of the breast with pure sarcomatous differentiation and the absence of epithelial elements should be regarded as soft tissue sarcomas 51…”

Section: Pathologymentioning

confidence: 99%

Phyllodes tumours

Parker

Harries

2001

Postgraduate Medical Journal

290

345

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Phyllodes tumours are rare fibroepithelial lesions that account for less than 1% of all breast neoplasms. With the non-operative management of fibroadenomas widely adopted, the importance of phyllodes tumours today lies in the need to diVerentiate them from other benign breast lesions. All breast lumps should be triple assessed and the diagnosis of a phyllodes tumour considered in women, particularly over the age of 35 years, who present with a rapidly growing "benign" breast lump. Treatment can be by either wide excision or mastectomy provided histologically clear specimen margins are ensured. Nodal metastases are rare and routine axillary dissection is not recommended. Few reliable clinical and histological prognostic factors have been identified. Local recurrence occurs in approximately 15% of patients and is more common after incomplete excision. It can usually be controlled by further surgery. Repeated local recurrence has been reported without the development of distant metastases or reduced survival. Approximately 20% of patients with malignant phyllodes tumours develop distant metastases. Long term survival with distant metastases is rare. The role of chemotherapy, radiotherapy, and hormonal manipulation in both the adjuvant and palliative settings remain to be defined. (Postgrad Med J 2001;77:428-435)

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“…Distant disease has appeared as early as at the time of initial therapy or as late as 12 years [4], and it is believed that the hematogenous route is responsible for this tumor dissemination. It is extremely rare for the regional lymphatics to be involved [4,14]. In the present report, the patient presented 1 year after initial therapy with a solitary mandible lesion and accompanying trismus and pain.…”

Section: Discussionmentioning

confidence: 97%

“…Except for some notable exceptions, the treatment of metastatic disease has been disappointing [4]. Fernandez et al [14] reported a single case in which a lung metastasis was resected 6 years following the initial diagnosis of CP; however, the final outcome in this patient was not…”

Section: Discussionmentioning

confidence: 99%

Cystosarcoma phyllodes metastatic to the mandible

Abemayor¹,

Nast

Kessler³

1988

Journal of Surgical Oncology

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Cystosarcoma phyllodes of the breast appears to encompass a diverse group of tumors with variable clinical behaviors. Although the tumor can behave in a malignant fashion, metastases to the head and neck region are distinctly uncommon. A case is presented of a solitary metastasis to the mandible appearing 1 year after mastectomy and in the absence of widespread disease. The metastatic potential of this neoplasm is discussed and involvement of the head and neck region is reviewed.

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Metastatic cystosarcoma phyllodes.A light and electron microscopic study

Cited by 30 publications

References 12 publications

Approaches to phyllodes tumour of the breast: a review article

Approaches to phyllodes tumour of the breast: a review article

Phyllodes tumours

Cystosarcoma phyllodes metastatic to the mandible

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