Metastatic Cutaneous Squamous Cell Carcinoma with Gastrointestinal Involvement: A Case Report

Abstract

Metastatic squamous cell carcinoma (SCC) involving the gastrointestinal tract as the sole site of metastatic disease is exceedingly rare. We report a patient with known cutaneous SCC that metastasized to regional lymph nodes who, after therapy, appeared to be disease free until a small metastatic lesion was identified on colonoscopy within a diverticular orifice. He was subsequently noted to have more diffuse gastrointestinal involvement, including a small bowel lesion not previously identified on imaging. The presence of a gastrointestinal metastatic lesion in this setting should prompt consideration to exclude other synchronous lesions and the need for possible additional systemic therapy.

Metastatic squamous cell carcinoma presenting as an ileocolonic fistula

“…Although our patient has no diagnosis of cutaneous SCC, we postulate there may be an undiagnosed lesion that could have metastasised to the bowel. Very few cases of metastatic colonic metastasis from cutaneous SCC have ever been reported 4,5 . Alternatively, the primary origin may have been oropharyngeal, lung or anogenital however with thorough investigation we have not diagnosed our patient with any other source.…”

“…Very few cases of metastatic colonic metastasis from cutaneous SCC have ever been reported. 4,5 Alternatively, the primary origin may have been oropharyngeal, lung or anogenital however with thorough investigation we have not diagnosed our patient with any other source.…”

Metastatic Cutaneous Squamous Cell Cancer with Peritoneal Carcinomatosis: A Case Report

“…Actinic keratosis and Bowen's disease, if left untreated, can progress to invasive cSCC [9]. Other less common risk factors encompass prior therapy with immunosuppressive agents and immunosuppressed populations such as transplant recipients [10,11]. Certain genetic syndromes such as albinism and xeroderma pigmentosum and certain settings of immunosuppression (lymphoma, chronic lymphocytic leukemia and HIV) predispose affected individuals to cSCC.…”

Undiagnosed metastatic ileocecal carcinoma: a rare aetiology for Fournier gangrene

“…4 Klebsiella pneumoniae, isolated from debrided tissue in our patient, is prevalent in FG patients who require mechanical ventilation for bacterial pneumonia. 5 Several predisposing conditions have been identified which create a favourable micro-environment that promotes the spread of the infection. 6 Malignancy, including occult colorectal malignancy, has been identified as a comorbid condition, and has been associated with higher death rate.…”

“…Non-surgical pneumoperitoneum has been recognized in various situations, including blunt trauma, sexual activity, post gastrointestinal endoscopic procedures, ruptured pyometra, cardiopulmonary resuscitation, etc. [1][2][3] Several authors described that a gas-producing TOA presents as pneumoperitoneum, 4,5 but it is still rare and significant for clinicians, as demonstrated in this case.…”