Metastatic Crohn's disease in paediatrics: Vulvar lesions as the first clinical presentation

Castro, Luís Ferreira de; Gomes, Rita; Sá, Diogo Cunha e; Fernandes, E. Vale; Lima, Rosa; Tavares, Marta

doi:10.1111/jpc.16471

J Paediatrics Child Health

2023

DOI: 10.1111/jpc.16471

|View full text |Cite

Metastatic Crohn's disease in paediatrics: Vulvar lesions as the first clinical presentation

Luís Ferreira de Castro

Rita Gomes

Diogo Cunha e Sá

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 7 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Vulvar skin disease in the pediatric population

Griffith,

Hunt,

Marathe

2024

Current Opinion in Pediatrics

View full text Add to dashboard Cite

Purpose of review Vulvar skin disease is an underrecognized pediatric condition encompassing a wide range of conditions, from isolated vulvar disease to vulvar manifestations of systemic illnesses. This review highlights the most current research discussing clinical features, risk factors, and treatments. Recent findings Recent studies confirm that labial adhesions resolve more quickly with estrogen treatment. Topical corticosteroids remain first-line for treatment of vulvar lichen sclerosus, and some procedural interventions are showing promising results. Latest evidence shows efficacy of biologic agents in hidradenitis suppurativa and vulvar Crohn's. Vaginal voiding remains an underrecognized cause of irritant vulvovaginitis. Lately vulvar aphthae have been associated with coronavirus disease 2019. Distinguishing between infantile perianal pyramidal protrusion, molluscum, and condyloma can be aided by differences in morphologic features. Summary Vulvar dermatoses have a high impact on children's health and wellbeing. Clinician familiarity with recognition and latest advancements in vulvar dermatoses can aid in prompt diagnosis, management, and appropriate referrals. Vulvar biopsy and vaginal cultures should be used prudently. Treatments include topicals, behavioral modification, systemic medications, and procedures.

show abstract

Vulvar skin disease in the pediatric population

Griffith,

Hunt,

Marathe

2024

Current Opinion in Pediatrics

View full text Add to dashboard Cite

show abstract

Fistulising skin metastases in Crohn’s disease: a case report and review of the literature

Elger,

Loibl,

Buechler

et al. 2024

J Med Case Reports

View full text Add to dashboard Cite

Background Metastatic Crohn’s disease is a rare disorder characterized by various granulomatous skin lesions that occur independently of gastrointestinal tract involvement. However, currently there is no standardized care or specific treatment. Therapeutic approaches include immunosuppressive agents, such as corticosteroids, azathioprine, and monoclonal antibodies targeting inflammatory cytokines like tumor necrosis factor (TNF). Case presentation We present a case of a 29-year-old western European woman with significant blind ending abdominal subcutaneous fistulas and abscesses, who sought evaluation in the dermatology department. Histological examination revealed multiple epithelioid cell granulomas. There was no evidence of infectious or rheumatologic diseases such as sarcoidosis. The tentative diagnosis was metastatic Crohn’s disease, which was not related to an intestinal manifestation of the disease. The patient responded to infliximab but had to discontinue it due to an allergic reaction. Subsequent adalimumab treatment failed to induce clinical remission; thus, therapy was switched to ustekinumab, resulting in a positive response. Written informed consent for publication of their clinical details and clinical images was obtained from the patient. For our study more than 1600 publications were screened for cases of metastatic Crohn’s disease on PubMed database. 59 case reports with 171 patients were included in the analysis and evaluated for localization, diagnostic and therapeutic approaches, and complications and were summarized in this review. Conclusion The successful ustekinumab treatment of a patient with metastatic Crohn's disease underscores the potential of this minimally investigated therapeutic option, highlighting the need for future treatment guidelines given the increasing prevalence of such cases.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Metastatic Crohn's disease in paediatrics: Vulvar lesions as the first clinical presentation

Cited by 2 publications

References 7 publications

Vulvar skin disease in the pediatric population

Vulvar skin disease in the pediatric population

Fistulising skin metastases in Crohn’s disease: a case report and review of the literature

Contact Info

Product

Resources

About