Metastatic Crohn’s disease: an underestimated entity

Ickrath, Franziska; Stoevesandt, Johanna; Schulmeyer, Lena; Glatzel, Caroline; Goebeler, Matthias; Kerstan, Andreas

doi:10.1111/ddg.14447

Cited by 15 publications

(23 citation statements)

References 13 publications

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“…The dermatologic phenomenon known as metastatic CD is probably underreported [38]. We were only able to find it in two cases in our patient cohort (data not shown).…”

Section: Discussionmentioning

confidence: 59%

Temporal Relationship of Extraintestinal Manifestations in Inflammatory Bowel Disease

Fedor

Zöld

Barta

2021

JCM

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Objectives: Thus far, few attempted to characterize the temporal onset of extraintestinal manifestations (EIM) in inflammatory bowel diseases (IBD). We sought to determine the time of onset of these findings in a patient cohort with IBD. Methods: We reviewed the electronic health records of 508 IBD patients (303 CD, 205 UC) and summarized general patient characteristics and the temporal relationship and order of presentation of extraintestinal manifestations. Results: CD patients were younger at diagnosis. CD patients with ileocolonic involvement (L3) were younger, and UC patients with pancolitis (E3) were slightly younger at diagnosis. A total of 127 out of 303 (41.91%) CD and 81 out of 205 (39.51%) UC patients had EIMs (p = 0.5898). Some patients presented with EIMs before the diagnosis of IBD (9.45% of Crohn’s disease and 17.28% of ulcerative colitis patients with EIMs, respectively). Of these, seven cases (four in CD and three in UC) were visible by inspection of the patients (either dermatologic or ocular findings). The diagnosis of IBD and extraintestinal symptoms often occurred within a year (22.83% of CD and 16.04% of UC patients). Typically, the diagnosis of the first extraintestinal symptoms happened after the onset of bowel disease (+4.3 (±6.3) years, range: 10 years before to 30 years after in Crohn’s disease and +3.8 (±10) years, range: 24 years before to 30 years after) in ulcerative colitis. UC patients with pancolitis (E3) usually had EIMs earlier in the disease course and displayed EIMs more frequently before IBD diagnosis. Furthermore, patients with pancolitis developed EIMs more frequently than other sub-groups. Conclusion: Extraintestinal manifestations in inflammatory bowel diseases can present at any time, relative to the bowel symptoms. In cases, the presence of a characteristic EIM might be a harbinger of the development of IBD.

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“…The dermatologic phenomenon known as metastatic CD is probably underreported [38]. We were only able to find it in two cases in our patient cohort (data not shown).…”

Section: Discussionmentioning

confidence: 59%

Temporal Relationship of Extraintestinal Manifestations in Inflammatory Bowel Disease

Fedor

Zöld

Barta

2021

JCM

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“… 5 MCD is difficult to treat, with partial improvement ranging from 30% for topical corticosteroids to 70% for anti-TNF, azathioprine, and systemic corticosteroids as monotherapy and in combination. 6 …”

Section: Discussionmentioning

confidence: 99%

“… 7 CD11c dendritic cells and CD68 macrophages in MCD (but not the granulomas) have also been shown to express interleukin 23. 6 …”

Section: Discussionmentioning

confidence: 99%

Refractory metastatic Crohn’s disease responsive to ustekinumab dose intensification

Xiao¹,

Ezenwa²,

Luzuriaga³

et al. 2023

JAAD Case Reports

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“…This is to be distinguished from metastatic Crohn's disease, in which skin lesions with histologically non-caseating granulomas do occur in the gastrointestinal tract without continuity. 9 The most important differential diagnoses for the oral manifestations of Crohn's disease in children include mycological, bacterial, or viral infections and other granulomatous diseases such as Melkersson-Rosenthal syndrome. Additionally, the consequences of malnutrition or chronic inflammation have to be considered, as well as reactive gingival hyperplasia due to the usage of specific medicines (for example, ciclosporin).…”

Section: Discussionmentioning

confidence: 99%

Persistent oral mucosal changes in a 7‐year‐old boy

Schroeder

Lorenzen

Fölster‐Holst

2023

J Deutsche Derma Gesell

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Metastatic Crohn’s disease: an underestimated entity

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 15 publications

References 13 publications

Temporal Relationship of Extraintestinal Manifestations in Inflammatory Bowel Disease

Temporal Relationship of Extraintestinal Manifestations in Inflammatory Bowel Disease

Refractory metastatic Crohn’s disease responsive to ustekinumab dose intensification

Persistent oral mucosal changes in a 7‐year‐old boy

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