Metastatic colorectal adenocarcinoma in cervicovaginal cytology specimens confirmed by immunocytochemical stains on liquid base specimens: Two study cases with review of the literature

Zulfiqar, Muhammad; Liu, Susan; Shi, Dan; Madan, Shashi; Jacques, Suzanne M.; King, LaQuita; Shidham, Vinod B.; Giorgadze, Tamara

doi:10.4103/1742-6413.112297

Cited by 8 publications

(7 citation statements)

References 14 publications

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“…In pathology study practice, CK7 and CK20 immunoexpresssions are commonly used in combination to evaluate immunoreactivity pattern in tumor cells, to confirm the origin of metastatic disease with unknown primary sites [ 13 ]. CK7 immunoreactivity is observed in tumors of lung, breast, upper gastrointestinal and pancreatobiliary tract, endometrium, vagina, and ovary, while tumors of colonic origin are generally non-reactive to this immunomarker.…”

Section: Case Presentationmentioning

confidence: 99%

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Uterine cervix metastasis from a sigmoid adenocarcinoma: a rare presentation of an uncommon tumor

Berhili

Khannoussi²,

Kadiri

et al. 2014

gynaecol oncol res pract

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Metastatic carcinoma to the uterine cervix from colorectal cancer, through haematogenous or lymphatic spread, is extremely rare. We report the case of a 59 year old woman in whom cervical metastasis was diagnosed after 13 months of follow-up for a sigmoid adenocarcinoma, confirmed by immunohistochemical study, with a review of the literature. This case illustrates that abnormal gynecologic symptoms can reveal a disease progression on patients who suffer colorectal cancer.Electronic supplementary materialThe online version of this article (doi:10.1186/2053-6844-1-6) contains supplementary material, which is available to authorized users.

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Section: Case Presentationmentioning

confidence: 99%

“…Thereby, in routine clinical practice and as we did, a panel combining [CK7-/CK20+/CDX2+] is used to confirm colonic primary origin [ 9 , 13 ].…”

Section: Case Presentationmentioning

confidence: 99%

Uterine cervix metastasis from a sigmoid adenocarcinoma: a rare presentation of an uncommon tumor

Berhili

Khannoussi²,

Kadiri

et al. 2014

gynaecol oncol res pract

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“…16,17 When reactive and metaplastic endometrial lesions, poorly or undifferentiated carcinomas and metastatic adenocarcinomas are included as differentials, cytologic diagnosis of endometrial carcinomas on cervical cytology is often difficult in practice. 18,19 This study reports an undescribed cytomorphological feature for identifying endometrioid carcinomas in cervical cytology. Over 70% of endometrial carcinomas are of endometrioid histology, 20,21 of which many show evidence of squamous differentiation with the formation of squamous morules and even frank squamous differentiation or keratinization.…”

Section: Discussionmentioning

confidence: 97%

Keratinization in atypical glandular cell clusters as a cytological clue to endometrioid carcinoma on cervical cytology

Ng,

2023

Cytopathology

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IntroductionSpecific diagnosis of endometrial carcinomas on cervical cytology is difficult with few useful cytomorphological clues reported. This study reviews a cohort of cervical cytology to investigate the presence of keratinization in atypical glandular cells (AGC), an undescribed cytomorphological clue for identifying endometrial endometrioid carcinomas on cervical cytology.MethodsCervical cytology slides from patients with a histologic diagnosis of endometrial endometrioid carcinoma were reviewed for the presence of keratinization associated with AGCs. Corresponding histology slides were reviewed for tumour grading and degree of squamous differentiation.ResultsIn total, 42 cases of cervical cytology specimens from 41 patients were retrieved, including 7 (16.7%) with keratinization associated with AGCs seen and 35 (83.3%) without. Comparison of histologic grading did not demonstrate an association with the presence of keratinization on cytology (p = 0.565). Corresponding histology slides were available for 37 cases. Cytologic and histologic keratinization were associated statistically (p = 0.002). Frank keratinization was seen on histologic slides of five cases, with four also showing cytologic keratinization. Area of squamous differentiation, including squamous morule formation, did not correlate with keratinization on cytologic preparation (p = 0.185).ConclusionHistologic and cytologic keratinization are observed in endometrioid endometrial carcinomas. Such is reflected in cervical cytology by the presence of orangeophilic, rigid and acellular fragments within or associated with AGC clusters. Keratinization, when identified with AGCs, should be regarded as a cytologic clue suggestive of an endometroid carcinoma of endometrial origin.

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“…In these cases, Immuno-histo-chemistry (IHC) is indispensable to differentiate a genital from the extragenital origin of the uterine cervix tumor. IHC profile, CK20 positive and CK7 negative, reveals metastasis from colorectal cancer primary [ 14 , 15 ]. CDX2 immunoexpression has proven to be useful in establishing gastrointestinal origin in metastatic tumors[ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Uterine cervix metastasis from primary colon adenocarcinoma: a case report and review of the literature

et al. 2021

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Introduction Metastases to the female genital tract from extragenital primary tumors are unusual. We report a rare case of uterine cervix metastasis from colon adenocarcinoma and discuss diagnostic and therapeutic issues. Case report We report a case of a 38-year-old North African Caucasian woman treated for a non-metastatic colon adenocarcinoma. She had a sigmoidectomy and incomplete adjuvant chemotherapy. Six months later, she consulted with vaginal bleeding caused by a cervical tumor, which was confirmed to be metastatic disease, and the patient underwent decompressive and hemostatic radiotherapy. Conclusion Uterine cervix metastasis from primary colon adenocarcinoma is rare. The resection remains the standard protocol for the local treatment of resectable metastatic disease. Otherwise, systemic therapy is the preferable option.

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Metastatic colorectal adenocarcinoma in cervicovaginal cytology specimens confirmed by immunocytochemical stains on liquid base specimens: Two study cases with review of the literature

Cited by 8 publications

References 14 publications

Uterine cervix metastasis from a sigmoid adenocarcinoma: a rare presentation of an uncommon tumor

Uterine cervix metastasis from a sigmoid adenocarcinoma: a rare presentation of an uncommon tumor

Keratinization in atypical glandular cell clusters as a cytological clue to endometrioid carcinoma on cervical cytology

Uterine cervix metastasis from primary colon adenocarcinoma: a case report and review of the literature

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