Metastatic colon cancer from intrahepatic cholangiocarcinoma

Wakahara, Tomoyuki; Tsukamoto, Tadashi; Kitamura, Shizuo; Watanabe, Akihiko; Tsujimura, Takuya; Nakamura, Yoshiki; Toyokawa, Akihiro; Onishi, Norihito; Hamabe, Yutaka; Mukai, Hidekazu; Teramura, Kazuhiro

doi:10.1007/s00534-005-0991-2

Cited by 13 publications

(12 citation statements)

References 11 publications

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“…Previous studies have not reported the metastasis of CC into the colon in domestic and wild animals (Lepri et al 2013). In humans, however, CC may metastasise, although rarely, into the colon (Wakahara et al 2005). We also observed, unlike other studies, metastasis of the CC into the caecum and ileocecal area.…”

Section: Discussioncontrasting

confidence: 54%

Cholangiocarcinoma of intrahepatic bile ducts with disseminated metastases in a Siamese cat: a case report

Aslan¹,

Çakir²,

Bekdik³

et al. 2014

Vet. Med. - Czech

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This case report concerns a four-year-old female Siamese cat which presented with inappetence, vomiting and weight loss. During routine clinical examinations of the patient, numerous neoplastic masses were detected in the liver, lungs and abdomen. Upon a request from the owner, the cat was euthanised. At necropsy, the primary tumour was detected in the liver. The tumour was greyish-white, firm, and multi-nodular. There were metastases in the portal lymph nodes, diaphragm, omentum, colon, caecum and lungs. Histologically, the tumour was characterised by a tubular pattern with periodic acid-Schiff-positive secretory material in glandular and canal structures. The neoplastic cells were positive to broad-spectrum cytokeratin. Histochemical and immunohistochemical stains were consistent with an intrahepatic bile duct carcinoma. This is the first case to report the metastasis of a cholangiocellular carcinoma to the colon in cats.

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Section: Discussioncontrasting

confidence: 54%

Cholangiocarcinoma of intrahepatic bile ducts with disseminated metastases in a Siamese cat: a case report

Aslan¹,

Çakir²,

Bekdik³

et al. 2014

Vet. Med. - Czech

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“…Until now, unusual metastastic sites from cholangiocarcinoma were reported to be the colon, adrenal gland, skull bone, epididymis, corneal limbus, meninges, ovary, skeletal musle, and skin 2,8-15. Metastasis of a distal cholangiocarcinoma to the stomach has not been reported previously to our knowledge but, as in the above-mentioned sites, appears to be a rare site of metastasis of this tumor.…”

Section: Discussionmentioning

confidence: 78%

“…Although it comprises only 10-15% of all hepatobiliary neoplasms, its incidence is increasing 1. Frequent metastatic sites of biliary cancer are the liver, peritoneum, intra-abdominal lymph nodes, and lungs 2. Here, we describe a very rare case in which metastatic cholangiocarcinoma of the stomach was mistaken for primary gastric cancer in a patient who underwent Whipple's operation.…”

Section: Introductionmentioning

confidence: 89%

Distal Cholangiocarcinoma with Gastric Metastasis Mimicking Early Gastric Cancer

Kim

Lee²,

Moon³

et al. 2009

Gut Liver

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We report an unusual case of distal cholangiocarcinoma with gastric metastasis mimicking early gastric cancer. A 67-year-old woman presented with a 4-month history of abdominal pain after eating. Computed tomography showed a malignant tumor of the common bile duct located just above the intrapancreatic segment, and endoscopy revealed a 2-cm, flat, elevated lesion with convergence of the surrounding folds, situated at the gastric angle. Based on the endoscopic biopsy results, an adenocarcinoma, thought to be an early gastric cancer, was diagnosed. The patient underwent Whipples's operation. Histopathological findings showed that the adenocarcinomatous tissue was clearly demarcated and infiltrated the gastric mucosa and submucosa, leaving the gastric superficial mucosa intact. Both tumors showed similar pathological features and were positive for cytokeratin (CK)-19 and CK-7. These finding suggest distal cholangiocarcinoma with gastric metastasis.

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“…The recurrence patterns include intrahepatic recurrence, peritoneal dissemination, lymph nodes metastasis, and remote organ metastasis to sites such as lung and bone [3][4][5]. A solitary colon metastasis from ICC is unusual: To our knowledge, there are only two published reports of a solitary colon metastasis from ICC [6,7]. One case was synchronous, and the other was metachronous, occurring 5 years after resection of the primary tumor.…”

Section: Discussionmentioning

confidence: 78%

Intestinal obstruction caused by colonic metastasis from intrahepatic cholangiocarcinoma 6 years after removal of the primary tumor: report of a case

et al. 2012

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We report a case of intestinal obstruction caused by metastasis that manifested 6 years after surgery for intrahepatic cholangiocarcinoma (ICC). The patient, a 57-year-old man, had undergone resection of the hepatic left lobe, Spiegel lobe, and extrahepatic bile duct, following which histopathological examination had confirmed the diagnosis of ICC and that the resection margins were free from disease. There had been no signs of recurrence until an increase in the CA19-9 level was detected 6 years later. Colonoscopy revealed an ulcer-like lesion and stenosis at the level of the hepatic flexure. The patient was subsequently admitted to our hospital with abdominal pain and underwent right hemicolectomy with partial resection of hepatic segment V. Based on the immunohistological finding that the expression pattern of cytokeratins and mucins was consistent with ICC origin rather than colon cancer origin, we diagnosed colon metastasis from ICC.

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Metastatic colon cancer from intrahepatic cholangiocarcinoma

Cited by 13 publications

References 11 publications

Cholangiocarcinoma of intrahepatic bile ducts with disseminated metastases in a Siamese cat: a case report

Cholangiocarcinoma of intrahepatic bile ducts with disseminated metastases in a Siamese cat: a case report

Distal Cholangiocarcinoma with Gastric Metastasis Mimicking Early Gastric Cancer

Intestinal obstruction caused by colonic metastasis from intrahepatic cholangiocarcinoma 6 years after removal of the primary tumor: report of a case

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