Metastatic chorionepithelioma of the gingival tissue

Englert, Raymond J.; Pasqual, Harry N.

doi:10.1016/0030-4220(57)90109-3

Cited by 15 publications

(2 citation statements)

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“…Metastases to the oral cavity or oropharynx are rare. The most common tumor sites of origin are lungs (20%), kidney (16%), breast (11%), and gastrointestinal tract (colon and stomach (9%) [7,8], with only a few cases reported in the English literature of ChC metastatic to the oral cavity but not oropharynx [8][9][10][11][12][13][14]. Extragonadal non-gestational midline ChC is a malignant, germ cell tumor composed of extraembryonic chorion that includes cytotrophoblastic and syncytiotrophoblastic cells, representing an incidence of 0.0022 per 1,000,000 people [6].…”

Section: Introductionmentioning

confidence: 99%

Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation

Payne

Palma

Walker

et al. 2020

Head and Neck Pathol

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Extragonadal non-gestational choriocarcinoma is a rare but well-described phenomenon occurring in patients with midline germ cell tumors. Choriocarcinoma (ChC) is an aggressive neoplasm usually developing in women as a rare complication of pregnancy. In male patients ChC occurs in the testes, usually as a component of mixed germ cell tumors. Very few patients develop extragonadal choriocarcinoma with the tumor occurring in midline locations, such as the mediastinum, retroperitoneum, and central nervous system (mostly pineal gland). Non-midline choriocarcinoma can occur in the lung, gastrointestinal tract, and breast, sometimes blended with another primary malignancy. A midline choriocarcinoma manifesting as a head and neck malignancy is exceptional. During an evaluation of multiple enlarged cervical lymph nodes suspected to be lymphoma in a 72-year-old man, a core biopsy was taken from one of the left neck lymph nodes which histologically showed a necrotic malignancy with strong diffuse pancytokeratin staining. After an initial interpretation of metastatic carcinoma, further samples were taken from both tonsils and from a right level 5 neck lymph node. Histologically, all samples contained the same tumor, showing profound pleomorphism and multinucleated syncytial-type giant cells. A panel of immunohistochemistry studies were performed, including β-human chorionic gonadotropin, with positive findings leading to a diagnosis of extragonadal non-gestational choriocarcinoma.

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Section: Introductionmentioning

confidence: 99%

Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation

Payne

Palma

Walker

et al. 2020

Head and Neck Pathol

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“…Choriocarcinoma is a highly-malignant tumor occurring in the reproductive organs and midline regions of the body, thought it is rarely present in males, as most tumors originate from gonadal or extragonadal germ cells. The tumor is prone to blood-born metastasis to the lungs, liver, intestines, spleen, adrenal glands, and brain; however, it is extremely rare in the oral cavity (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Metastasis in the oral region is generally presents as a secondary tumor after the original tumor has spread widely throughout the body.…”

Section: Introductionmentioning

confidence: 99%

Choriocarcinoma of the Mandible Developing after Odontogenic Keratocyst Excision

Matsumoto

Matsumoto²,

Tanaka³

et al. 2003

Oral Med Pathol

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We describe an unusual case of metastatic choriocarcinoma of the mandible. Sixteen months after odontogenic keratocyst excision, the tumor was found growing in the left molar region of the mandible, the same site of the previously enucleated odontogenic keratocyst.Histopathological examination revealed sheets of atypical cells similar to syncytiotrophoblast or cytotrophoblast, and the tumor was diagnosed as metastatic choriocarcinoma of unknown origin. A whole-body examination was performed; however, the tumor origin was not determined. Surgical excision of the tumor was performed due to rapid growth. One month after tumor excision, multiple tumor masses were detected in both lung lobes by the chest Xray examination. In addition, a high level of serum hCG was detected. The clinical course and histopathological findings, this unusual choriocarcinoma are discussed with referring to the literature.

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Tumors of the Nose and Throat Summaries of the Bibliographic Material Available for 1956-1957

Devine¹

1961

Archives of Otolaryngology - Head and Neck Surgery

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Metastatic chorionepithelioma of the gingival tissue

Cited by 15 publications

References 1 publication

Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation

Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation

Choriocarcinoma of the Mandible Developing after Odontogenic Keratocyst Excision

Tumors of the Nose and Throat Summaries of the Bibliographic Material Available for 1956-1957

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