Metastatic cerebral choriocarcinoma with primary neurological presentation

Ilancheran, A.; Ratnam, S. S.; Baratham, Gopal

doi:10.1016/0090-8258(88)90236-3

Cited by 13 publications

(4 citation statements)

References 4 publications

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“…Gestational choriocarcinoma is a malignant neoplasm that arises from placental trophoblastic tissue. It has a tendency to early metastases, especially to the lungs, brain, liver and vagina 6 . The clinical presentation of cerebral involvement include raised intracranial pressure, intracerebral haemorrhage and cerebral ischaemic infarction.…”

Section: Discussionmentioning

confidence: 99%

Metastatic choriocarcinoma: A rare cause of stroke in the young adult

Saad

Tang

Sclavos

et al. 2006

Australasian Radiology

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A 20-year old woman presented with acute right hemiplegia 10 weeks after intrauterine fetal death at 34-weeks gestation (G1P0). A brain MRI showed a typical acute infarct in the left middle cerebral artery territory. A CT pulmonary angiography carried out 1 week later for sudden cardiopulmonary deterioration showed disseminated pulmonary metastases. The CT was extended to the abdomen and pelvis, which showed a uterine mass with bilateral theca lutein cysts. The radiological diagnosis of metastatic choriocarcinoma was made and was subsequently confirmed with the markedly increased serum beta-human chorionic gonadotrophin. A serum beta-human chorionic gonadotrophin is therefore considered worthwhile in any young female adult who presents with stroke.

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Section: Discussionmentioning

confidence: 99%

Metastatic choriocarcinoma: A rare cause of stroke in the young adult

Saad

Tang

Sclavos

et al. 2006

Australasian Radiology

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“…It has a tendency to early metastasize, especially to the lungs, brain, liver, and vagina [31]. Brain metastases are relatively common complication involving about one-fifth of patients.…”

Section: Pregnancy-specific Causes Of Ischemic Strokementioning

confidence: 99%

Ischemic Stroke during Pregnancy and Puerperium

Zotto

Giossi²,

Volonghi³

et al. 2011

Stroke Research and Treatment

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Ischemic stroke during pregnancy and puerperium represents a rare occurrence but it could be a serious and stressful event for mothers, infants, and also families. Whenever it does occur, many concerns arise about the safety of the mother and the fetus in relation to common diagnostic tests and therapies leading to a more conservative approach. The physiological adaptations in the cardiovascular system and in the coagulability that accompany the pregnant state, which are more significant around delivery and in the postpartum period, likely contribute to increasing the risk of an ischemic stroke. Most of the causes of an ischemic stroke in the young may also occur in pregnant patients. Despite this, there are specific conditions related to pregnancy which may be considered when assessing this particular group of patients such as pre-eclampsia-eclampsia, choriocarcinoma, peripartum cardiomiopathy, amniotic fluid embolization, and postpartum cerebral angiopathy. This article will consider several questions related to pregnancy-associated ischemic stroke, dwelling on epidemiological and specific etiological aspects, diagnostic issue concerning the use of neuroimaging, and the related potential risks to the embryo and fetus. Therapeutic issues surrounding the use of anticoagulant and antiplatelets agents will be discussed along with the few available reports regarding the use of thrombolytic therapy during pregnancy.

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“…Primary surgery for choriocarcinoma metastases followed by chemotherapy with or without radiotherapy has been advocated, particularly if there is any evidence of raised intracranial pressure ( 8,15 , 22,25 ) . The reasoning for this approach is that surgical removal of the tumor lessens the likelihood of hemorrhage or tumor necrosis and resulting increase in mass effect that can occur when the patient is undergoing chemotherapy for the primary disease ( 2,8 , 26 ) . Surgery can also diminish the tumor load for the chemotherapy ( 8 ) .…”

Section: Discussionmentioning

confidence: 99%

The role of neurosurgery in the treatment of cerebral metastases from choriocarcinoma: a report of two cases

Semple

Denny²,

Coughlan³

et al. 2004

Int J Gynecol Cancer

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Cerebral metastases from choriocarcinoma are a poor prognostic indicator of outcome in both the World Health Organization and FIGO classification systems. However, with the increased experience with chemotherapy and radiotherapy the prognosis of this group of patients has improved substantially. Neurosurgery remains an option for selected patients. We present two patients who underwent craniotomy as part of their management of choriocarcinoma, and review the role of neurosurgery in the treatment of gestational trophoblastic disease.

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Metastatic cerebral choriocarcinoma with primary neurological presentation

Cited by 13 publications

References 4 publications

Metastatic choriocarcinoma: A rare cause of stroke in the young adult

Metastatic choriocarcinoma: A rare cause of stroke in the young adult

Ischemic Stroke during Pregnancy and Puerperium

The role of neurosurgery in the treatment of cerebral metastases from choriocarcinoma: a report of two cases

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