Metastatic Cardiac Angiosarcoma to the Lung, Spine, and Brain: A Case Report and Review of the Literature

Lin, Chih-Ta; Ducis, Katrina; Tucker, Suzanne; Tranmer, Bruce I.

doi:10.1016/j.wneu.2017.08.023

Cited by 12 publications

(5 citation statements)

References 49 publications

(100 reference statements)

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“…El angiosarcoma es una neoplasia muy agresiva, con un alto índice mitótico y capacidad de hacer metástasis por vía hematógena y linfática 12 . Los angiosarcomas primarios o metastásicos del sistema nervioso central son raros, con una incidencia en adultos de menos del 1 % 13 .…”

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Descripción clínico-radiológica de un angiosarcoma cardiaco con metástasis cerebral que simula un quiste hidatídico

2019

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Los angiosarcomas son sarcomas malignos que se originan en las células endoteliales vasculares. Su diagnóstico diferencial es muy amplio debido a su parecido con otras enfermedades, como las parasitarias, y usualmente es un diagnóstico por exclusión. La neurocisticercosis y la hidatidosis cerebral son parasitosis intestinales que pueden comprometer el sistema nervioso central y tienen mayor incidencia en los países suramericanos.El diagnóstico se establece a partir del perfil epidemiológico, el estudio parasitológico, la apariencia radiológica de las lesiones y el estudio de histopatología del espécimen.Se presenta el caso de una adolescente con factores de riesgo para parasitosis y neuroimágenes sugestivas de hidatidosis cerebral, cuyo diagnóstico definitivo fue angiosarcoma cardiaco metastásico.

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Section: Discussionunclassified

Descripción clínico-radiológica de un angiosarcoma cardiaco con metástasis cerebral que simula un quiste hidatídico

2019

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“…Among malignant cardiac tumors, sarcomas are the most frequent 7 , 8. Cardiac angiosarcomas are very aggressive neoplasms, with a high rate of local recurrence and systemic metastasis 7 - 9. Males are two to three times more affected than females, and most patients are young.…”

Section: Discussionmentioning

confidence: 99%

Multiple hepatic metastases of cardiac angiosarcoma

et al. 2018

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The differential diagnosis of hepatic focal lesions is challenging because the etiology can be inflammatory, infectious, and even neoplastic. A rare cause of metastatic liver nodules is cardiac angiosarcoma. We report a case of this tumor, which was diagnosed only after autopsy.A 26-year-old Caucasian man was admitted for progressive dyspnea and cough over the past 3 weeks. Physical examination showed only hypophonetic heart sounds. Laboratory analysis demonstrated anemia and elevated inflammatory markers, despite normal biochemical parameters and liver function. Transthoracic echocardiography revealed massive pericardial effusion. Abdomen computed tomography (CT) showed multiple hepatic nodules, the largest of which measured 3 cm, but the percutaneous biopsy revealed only lobular necrosis and perisinusoidal fibrosis without granulomas or neoplastic cells. During hospitalization, the patient had fever and night sweats with weight loss, and empiric treatment for extrapulmonary tuberculosis associated with corticosteroids was initiated. The outpatient follow-up revealed complete improvement of the pericardial effusion, but maintenance of the liver lesions. After 2 months of hospital discharge, the patient was readmitted with hemorrhagic shock due to bleeding liver lesions, which were evidenced by CT. Embolization of the right hepatic artery was performed, but the patient soon died. The autopsy revealed a primary cardiac angiosarcoma with multiple hepatic metastases, rupture of the Glisson’s capsule and laceration of the liver. The case shows how important and difficult the diagnosis of focal liver lesions is, since it may result in an unexpected fatal outcome.

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“…Angiosarcoma is rare, causing less than 1% of sarcomas 1 . Brain involvement is typically due to metastasis; the heart is a common primary site 1,2 . Treatment involves gross total resection followed by chemotherapy, radiotherapy, and local brachytherapy 1,2 .…”

Section: Figurementioning

confidence: 99%

“…1 Brain involvement is typically due to metastasis; the heart is a common primary site. 1,2 Treatment involves gross total resection followed by chemotherapy, radiotherapy, and local brachytherapy. 1,2 Neurologists should be aware of this rare diagnosis and the need for advanced imaging, typically with cardiac MRI.…”

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confidence: 99%