Metastatic carcinoma of the breast. An unusual presentation mimicking cutaneous vasculitis

Pickard, Clay; Callen, Jeffrey P.; Blumenreich, Martin S.

doi:10.1002/1097-0142(19870315)59:6<1184::aid-cncr2820590625>3.0.co;2-k

Cited by 24 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TMBC appears to be very rare. Only a few cases have been reported in the English language literature 3–10 . We report a new case of TMBC in a 72‐year‐old woman presenting with an extensive papulovesicular rash of several months' duration on the right arm.…”

mentioning

confidence: 93%

“…Clinically, TMBC is characterized by yellowish to reddish or violaceous papulovesicles ipsilateral to the side affected by breast cancer 1 . Other manifestations, such as a purpuric plaque mimicking vasculitis 9 or an angiosarcoma‐like lesion, 10 have also been reported. Histologically, adenomatous tumour nests of TMBC are found in dilated, and often congested, small blood vessels mainly in the subepidermal zone 3,4,7 .…”

mentioning

confidence: 99%

“…Only a few cases have been reported in the English language literature. [3][4][5][6][7][8][9][10] We report a new case of TMBC in a 72-year-old woman presenting with an extensive papulovesicular rash of several months' duration on the right arm. She had had breast carcinoma of the right breast which was diagnosed 12 years previously and was treated with modified radical mastectomy without adjuvant therapy.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Telangiectatic metastatic breast carcinoma preceded by en cuirasse metastatic breast carcinoma

et al. 2004

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 93%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Telangiectatic metastatic breast carcinoma preceded by en cuirasse metastatic breast carcinoma

et al. 2004

View full text Add to dashboard Cite

show abstract

“…The single reported case of telangiectatic metastatic prostate cancer presented as a plaque resembling angiosarcoma of the scalp 3 . Histological examination demonstrates ectatic, often engorged, and predominantly superficial dermal blood vessels that contain erythrocytes and aggregates of neoplastic cells that frequently appear ‘free‐floating’ within the vascular lumina 24,26,28 . Metastases from a prostatic primary carcinoma have the typical histological features of prostatic adenocarcinoma and are immunoreactive for both PSA and prostatic acid phosphatase 2 …”

Section: Atypical Clinical Presentations Of Cutaneous Metastatic Promentioning

confidence: 99%

Telangiectatic cutaneous metastasis from carcinoma of the prostate

2007

View full text Add to dashboard Cite

References1 Wade TR, Kopf AW, Ackerman AB. Bowenoid papulosis of the genitalia. Arch Dermatol 1979; 115:306-8. 2 Kreuter A, Brockmeyer NH, Hochdorfer B et al. Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection. J Am Acad Dermatol 2005; 52:603-8. 3 Weissenborn SJ, Funke AM, Hellmich M et al. Oncogenic human papillomavirus DNA loads in human immunodeficiency virus-positive women with high-grade cervical lesions are strongly elevated. J Clin Microbiol 2003; 41:2763-7. 4 Patterson JW, Kao GF, Graham JH, Helwig EB. Bowenoid papulosis: a clinicopathologic study with ultrastrucural observations. Cancer 1986; 57:823-36. 5 Yoneta A, Yamashita T, Jin HY et al. Development of squamous cell carcinoma by two high-risk human papillomaviruses (HPVs), a novel HPV-67 and HPV-31 from bowenoid papulosis. Br J Dermatol 2000; 143:604-8. 6 Hama N, Ohtsuka T, Yamazaki S. Elevated amount of human papillomavirus 31 DNA in a squamous cell carcinoma developed from bowenoid papulosis. Dermatology 2004; 209:329-32. 7 Sano T, Oyama T, Kashiwabara K et al. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol 1998; 153: 1741-8. 8 Snijders PJ, Hogewoning CJ, Hesselink AT et al. Determination of viral load thresholds in cervical scrapings to rule out CIN 3 in HPV 16, 18, 31 and 33-positive women with normal cytology. Int J Cancer 2006; 119:1102-7. 9 Jacobs MV, Snijders PJ, van den Brule AJ et al. A general primer GP5+/GP6(+)-mediated PCR-enzyme immunoassay method for rapid detection of 14 high-risk and 6 low-risk human papillomavirus genotypes in cervical scrapings. J Clin Microbiol 1997; 35: 791-5. 10 van den Brule AJ, Pol R, Fransen-Daalmeijer N et al. GP5+/6+ PCR followed by reverse line blot analysis enables rapid and highthroughput identification of human papillomavirus genotypes. SIR, The inflammatory vesicobullous first stage of incontinentia pigmenti (IP) can recur, albeit rarely. It has previously been described only in infants and young children under the age of 18 months and it has usually been preceded by a systemic infection.A 5-year-old schoolgirl presented with a 2-day history of a linear rash on her right leg extending from the medial knee to the buttock and consisting of vesicobullous lesions arising on inflamed skin (Fig. 1). There was no history of anteceding

show abstract

“…11,12 The most common presentation of cutaneous metastases is as a painless nodule, 4,6,7 but metastases to the skin have been reported as bullae, 5 inflammatory carcinoma, 13 zosteriform rashes, 14,15 sclerotic plaques, 15 and mimicking cutaneous vasculitis. 16 The most common primary tumor of cutaneous metastases in women is breast carcinoma, comprising approximately 60%-70% of all cutaneous metastases in women. [5][6][7]17 Other common primaries in females are melanoma (5%-12%), gastrointestinal tract (2%-9%), lung (2%-4%), and ovary (3%-4%).…”

mentioning

confidence: 99%

Primary Cutaneous Adnexal Neoplasms and Their Metastatic Look-Alikes

Perna

Prieto²,

Lazar³

et al. 2007

Pathology Case Reviews

View full text Add to dashboard Cite

Cutaneous adnexal neoplasms can often be confused with other entities, including cutaneous metastases from visceral malignancies. Distinguishing primary cutaneous adnexal neoplasms from metastases is important, as the presence of cutaneous metastases can sometimes be the first sign of an internal malignancy or, more often, can indicate a poor prognosis due to disseminated disease. Primary cutaneous adnexal tumors with clear cell histology such as sebaceous tumors or clear cell hidradenoma can mimic metastatic clear cell renal cell carcinoma. Nonmucinous primary adnexal carcinomas derived from the sweat glands can mimic adenocarcinomas metastatic from the breast, lung, gastrointestinal tract, and elsewhere. Finally, mucinous sweat gland tumors also pose a challenge as they can mimic metastatic mucinous carcinomas, particularly of the breast and gastrointestinal tract. This review includes the morphologic characteristics as well as suggested immunohistochemistry to aid in the distinction of these entities.T he category of cutaneous adnexal neoplasms is a complex one, comprising a large number of closely related entities with eccrine, apocrine, sebaceous, or follicular differentiation. Classification of the adnexal neoplasms can be confusing because they often encompass multiple, sometimes overlapping, lines of differentiation. Furthermore, their diagnosis can be challenging because they morphologically mimic other tumors, including cutaneous metastases of visceral malignancies. This is especially true for strictly intradermal tumors with no epidermal connection and in which a primary cutaneous benign adnexal tumor component is not readily identifiable.Cutaneous metastases have been reported to occur in 0.7% 1 to 9% 2 of patients with visceral tumors. A large retrospective study of patients with carcinoma, specifically excluding melanoma, found cutaneous metastases in 4.7% of these patients. 3 A recent meta-analysis including over 20,000 patients with carcinoma, again excluding melanoma, found the incidence of cutaneous metastases to be 5.3%. 4 Of all cancer patients with metastatic disease, approximately 10% of those metastases were to the skin and in roughly 3 quarters of those patients, the cutaneous metastases were the first sign of extranodal metastases. 5 The most common sites of cutaneous metastases include the abdominal wall and chest, although scalp and neck are less commonly seen. 5-7 This correlates with the observation that cutaneous metastases are most commonly seen in the skin in the region of the primary carcinoma, such as the chest for lung and breast carcinomas and the abdominal wall for gastrointestinal carcinomas. 5 Unusual sites of metastases have been reported including subungual 8 -10 and penis. 11,12 The most common presentation of cutaneous metastases is as a painless nodule, 4,6,7 but metastases to the skin have been reported as bullae, 5 inflammatory carcinoma, 13 zosteriform rashes, 14,15 sclerotic plaques, 15 and mimicking cutaneous vasculitis. 16 The most common primary tumor of cutaneou...

show abstract

Metastatic carcinoma of the breast. An unusual presentation mimicking cutaneous vasculitis

Abstract: Cutaneous metastatic disease which clinically mimics a cutaneous vasculitis developed in a 53-year-old postmenopausal women with Stage II adenocarcinoma of the breast. This unusual presentation is contrasted with the more common variants of cutaneous metastatic breast carcinoma.

Cited by 24 publications

References 15 publications

Telangiectatic metastatic breast carcinoma preceded by en cuirasse metastatic breast carcinoma

Telangiectatic metastatic breast carcinoma preceded by en cuirasse metastatic breast carcinoma

Telangiectatic cutaneous metastasis from carcinoma of the prostate

Primary Cutaneous Adnexal Neoplasms and Their Metastatic Look-Alikes

Contact Info

Product

Resources

About