Metastatic Carcinoma Masquerading as Primary Thyroid Cancer

Elliott, Robert H. E.; Frantz, Virginia Kneeland

doi:10.1097/00000658-196004000-00015

Cited by 152 publications

(76 citation statements)

References 12 publications

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“…Renal cell carcinoma is one of the cancers that is prone to metastasize to the thyroid (1,2), although clinically obvious metastatic thyroid nodules are rare. It has been reported (3) that fine needle aspiration cytology is useful to differentiate metastatic thyroid nodules from primary thyroid nodules, but the diagnosis is still made after surgery in most cases.…”

Section: Introductionmentioning

confidence: 99%

Identification of Metastatic Carcinoma in the Thyroid by Determination of Thyroglobulin Level in Aspirates and Ultrasonic Findings.

et al. 1993

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A 49-year-old female with a metastatic renal cell carcinoma to the thyroid is presented. The thyroglobulin (Tg) level in tumor aspirates of this patient was 37.3 jtig/l, while that of 49 patients with primary thyroid nodules ranged from 2.0 X 103 to 7.5 X 108/ig/l. Ultrasonogram of the thyroid demonstrated a well-demarcated oval nodule with a cystic region, the solid part of which was hypoechoic and homogeneous.However,similar ultrasonic findings were observed in only 1.1% of 1,054 patients with primary thyroid nodules. Determination of Tg in tumor aspirates and ultrasonography of the thyroid maycontribute to the differentiation of metastatic thyroid nodules from primary thyroid nodules. (Internal Medicine 32: 46-49, 1993)

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Section: Introductionmentioning

confidence: 99%

Identification of Metastatic Carcinoma in the Thyroid by Determination of Thyroglobulin Level in Aspirates and Ultrasonic Findings.

et al. 1993

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“…The incidence of thyroid metastases in clinical reports seems to have increased recently [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], with the most common primary carcinoma site being the kidney, followed by breast and lung [8][9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical reports have suggested, however, that the incidence of these metastases is increasing. The most common primary carcinoma sites in clinical reports are the kidneys, breasts, and lungs [8][9][10][11][12][13][14], although other primary carcinomas can also metastasize to the thyroid gland [15][16][17][18][19][20][21][22][23][24][25][26][27].…”

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confidence: 99%

Hepatocellular carcinoma eats medullary thyroid carcinoma, a case of tumor-in-tumor metastasis

Sung

Lee

et al. 2011

Endocr J

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Metastasis to the thyroid gland is uncommon, with previous autopsy series showing incidence rates ranging from 0.5% to 10.1% [1][2][3][4][5][6][7]. Clinical reports have suggested, however, that the incidence of these metastases is increasing. The most common primary carcinoma sites in clinical reports are the kidneys, breasts, and lungs [8][9][10][11][12][13][14], although other primary carcinomas can also metastasize to the thyroid gland [15][16][17][18][19][20][21][22][23][24][25][26][27].Hepatocellular carcinoma (HCC) rarely metastasizes to the thyroid [6,23,[25][26][27]. Here, we describe a patient with an HCC metastasis to within a medullary thyroid carcinoma (MTC), that is, a tumor-in-tumor metastasis. To our knowledge, this is the first such clinically diagnosed case.Due to the relatively short survival times of patients with distant metastases, solitary thyroid tumors in patients with advanced carcinoma are not routinely evaluated. However, imaging modalities, including fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and ultrasonography (US) guided fine-needle aspiration biopsy (FNAB) of newly detected Hepatocellular carcinoma eats medullary thyroid carcinoma, a case of tumor-in-tumor metastasis abstract. Carcinoma metastasis to the thyroid is uncommon, but may be increasing. We describe here a patient with a metastasis of hepatocellular carcinoma (HCC) presenting within a medullary thyroid carcinoma (MTC). The thyroid tumor was detected synchronously with the hepatic lesion by FDG-PET imaging, and HCC metastasis within MTC was confirmed by histological analysis of the thyroid gland.

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“…Two to three percent of all thyroid malignant tumors are metastatic; this incidence can be higher in autopsies, ranging from 5 to 24% [1][2][3][4][5], as part of widespread metastatic disease or direct invasion to the gland from an adjacent tumor [6]. Different types of solid tumors can metastasize to the thyroid including malignant melanoma, renal cell carcinoma (RCC), breast cancer, lung carcinoma, hematologic malignancies, and head and neck tumors [1,[7][8][9]. Interestingly, in the majority of the cases, the metastatic lesions are occult and only discovered during autopsy [1].…”

Section: Introductionmentioning

confidence: 99%

Tumor-to-Tumor Metastasis: Renal Cell Carcinoma Metastatic to Papillary Carcinoma of Thyroid—Report of a Case and Review of the Literature

Bohn

Casas²,

Leon

2009

Head and Neck Pathol

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Metastatic disease to thyroid gland is a rare event. Although renal cell carcinoma (RCC) has been reported to metastasize the thyroid gland, metastatic RCC to a thyroid neoplasm is very unusual. We report a case of a 68-year-old man with history of RCC who presented with a 2.5-cm thyroid nodule. Histologic examination demonstrates a renal cell carcinoma metastatic to a papillary carcinoma of the thyroid. The clinicopathologic features of metastatic disease into a thyroid gland neoplasm are shown, and a review of the literature is presented.

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Metastatic Carcinoma Masquerading as Primary Thyroid Cancer

Cited by 152 publications

References 12 publications

Identification of Metastatic Carcinoma in the Thyroid by Determination of Thyroglobulin Level in Aspirates and Ultrasonic Findings.

Identification of Metastatic Carcinoma in the Thyroid by Determination of Thyroglobulin Level in Aspirates and Ultrasonic Findings.

Hepatocellular carcinoma eats medullary thyroid carcinoma, a case of tumor-in-tumor metastasis

Tumor-to-Tumor Metastasis: Renal Cell Carcinoma Metastatic to Papillary Carcinoma of Thyroid—Report of a Case and Review of the Literature

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