Metastatic Carcinoid Tumour of the CNS from two different primary sites

Saleh, Jamshid; Afshar, F.

doi:10.3109/02688698709035313

Cited by 9 publications

(3 citation statements)

References 9 publications

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“…Carcinoid tumors were of bronchial (n = 9) and nonpulmonary origin (n = 17)-of which CNS (n = 2) and thymus (n = 3)-, and 4 patients had carcinoid tumors of unknown primary, whereas in 7 patients, the origin was not specified. [16][17][18][19][20][21][22][23][24][26][27][28][29][30][31][32]34,35,37,38,43 Only 6 pNET cases, including ours, of malignant spinal cord compression have been reported in the literature, 25,33,36,40,41 with two of them due to "functional" pNETs (ie, glucagonoma, gastrinoma). As far as we know, our case is the first ever reported of a pNETwith an "intradural" metastasis to the spinal cord, and we only found the following 4 other cases of spinal intradural NET metastases: 2 thymic carcinoids, 28,35 1 lung atypical carcinoid, 18 and a probable primary atypical carcinoid of the CNS.…”

Section: Discussionmentioning

confidence: 98%

“…42 Most of the cases (n = 35) are in fact extradural spinal cord compressions due to vertebral metastases with an epidural soft tissue component. 16,19,[21][22][23][24][25][26]29,[32][33][34][35][36][37][38][39]41,43 Reported cases include carcinoid tumors (n = 36), pNET (n = 6), and NETs of unknown primary (n = 3). Carcinoid tumors were of bronchial (n = 9) and nonpulmonary origin (n = 17)-of which CNS (n = 2) and thymus (n = 3)-, and 4 patients had carcinoid tumors of unknown primary, whereas in 7 patients, the origin was not specified.…”

Section: Discussionmentioning

confidence: 98%

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C8-T1 Radiculopathy Due to an Intradural Extramedullary Metastasis of a Pancreatic Neuroendocrine Tumor

et al. 2016

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Pancreatic neuroendocrine tumors (pNETs) are usually well-to-moderately differentiated neuroendocrine tumors (NETs) that most often metastasize to the liver and lymph nodes with other locations being uncommon. We present a case of intradural pNET metastasis and conduct a review of the literature. Forty-five cases, including the case presently reported, of spinal cord compression due to well-differentiated NETs were found: carcinoid (80%), pNET (13.3%), and NETs of unknown primary (6.7%). Seventy-eight percent of cases consisted of extradural compressions from vertebral bone metastases, whereas there were only 5 cases of intradural extramedullary spinal cord compression. Most cases were managed with surgery and/or radiotherapy with a good clinical outcome in the majority. We report the first case of a pNET intradural extramedullary metastasis and conduct the largest review to date of an infrequent complication of well-differentiated NETs such as malignant spinal cord compression. Aggressive local treatment is warranted in most cases because it usually achieves neurologic improvement and symptomatic relief in patients who may still have a long life expectancy.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

C8-T1 Radiculopathy Due to an Intradural Extramedullary Metastasis of a Pancreatic Neuroendocrine Tumor

et al. 2016

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“…Survival time presented in case reports varies from several weeks to several months. [5][6][7][8][9][10][11][12][13][14][15][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Patchell and Posner 16 reported a median survival time of 7 months, with 33 % of these patients surviving for Ͼ 1 year. In our patients, the overall median survival time after the diagnosis of brain metastasis was 10 months (95% CI, 4 -16 months), with 42 % of patients surviving for Ն 1 year.…”

Section: Discussionmentioning

confidence: 99%

Carcinoid metastasis to the brain

Hlatky

Suki

Sawaya

2004

Cancer

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BACKGROUND.Carcinoid tumors rarely metastasize to the brain. The objectives of the current study were to assess the frequency of brain metastasis from carcinoid tumors, determine correlates of survival, and describe treatment modalities and their outcomes. METHODS. BetweenJanuary 1977 and December 2003, 1633 patients with a carcinoid tumor were registered at The University of Texas M. D. Anderson Cancer Center. Of those, 24 patients (1.5%) had a diagnosis of brain metastasis. The authors collected demographic and clinical data and performed a statistical analysis. RESULTS.The median age at the time patients were diagnosed with brain metastasis was 60 years. The metastases were treated with whole-brain radiotherapy (WBRT) alone in 7 patients (29%), and 12 patients (50%) underwent surgical resection, 7 of whom (29%) also received WBRT. The median survival time for the entire cohort after diagnosis of the primary tumor was 2.3 years (95% confidence interval [CI], 0.5-4.1 years), and the median survival time after the diagnosis of brain metastasis was 10.0 months (95% CI, 4.0 -16.0 months). The longest median survival observed after the diagnosis of brain metastasis (3.2 years) occurred in patients who underwent resection and received WBRT. In the multivariate analysis, the adjusted rate ratio for comparison of all treatments versus combination of neurosurgical intervention and WBRT was 5.7 (95% CI, 1.3-26.1; P ϭ 0.024). A positive effect of surgery followed by WBRT on the duration of survival was detected in patients with a single metastasis (P ϭ 0.084) as well as in those with multiple metastases (P ϭ 0.018). CONCLUSIONS.Prolonged survival was observed in patients Ͻ 65 years old as well as in those who underwent surgery and received WBRT in comparison with other treatments. Whenever feasible, neurosurgical resection followed by WBRT seems to be the indicated treatment in patients with brain metastases from carcinoid tumors.

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Carcinoids

Debois¹

2000

Selected Topics in Clinical Oncology

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Metastatic Carcinoid Tumour of the CNS from two different primary sites

Cited by 9 publications

References 9 publications

C8-T1 Radiculopathy Due to an Intradural Extramedullary Metastasis of a Pancreatic Neuroendocrine Tumor

C8-T1 Radiculopathy Due to an Intradural Extramedullary Metastasis of a Pancreatic Neuroendocrine Tumor

Carcinoid metastasis to the brain

Carcinoids

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